Abaloparatide, wanda aka sayar a ƙarƙashin sunan alamar Tymlos, analog na roba ne na furotin da ke da alaƙa da parathyroid (PTHrP). Wani wakili ne na anabolic da aka yi amfani da shi don magance osteoporosis, yanayin da ke da rauni na kasusuwa da kuma haɗarin karaya. Ana nuna Abaloparatide ga matan da suka shude da maza masu fama da osteoporosis a babban haɗari ga karaya, da kuma waɗanda suka kasa ko kuma ba su jure wa sauran hanyoyin kwantar da hankali na osteoporosis. Ta hanyar zaɓin kunna mai karɓa na parathyroid hormone 1 (PTH1R), abaloparatide yana haɓaka haɓakar ƙashi kuma yana ƙara yawan kashi.
Abaloparatide shine analog na 34 na amino acid na roba na PTHrP, tare da 41% homology zuwa hormone parathyroid (PTH) (1-34) da 76% homology zuwa PTHrP (1-34). Tsarin aikinsa ya haɗa da ɗaure zuwa PTH1R, mai karɓa mai haɗakar furotin G wanda aka bayyana a cikin osteoblasts da osteocytes. Ta fifikon ɗaure ga yanayin daidaitawar RG na PTH1R, abaloparatide yana haifar da amsawar siginar AMP na cyclic na ƙasa, yana haifar da hanyar siginar anabolic.
A cikin matan da suka shude tare da osteoporosis a babban haɗari ga karaya, abaloparatide wani zaɓi ne mai mahimmanci na magani. Yana taimakawa wajen kara yawan kashi da rage hadarin karaya. Bugu da ƙari, ana iya amfani da abaloparatide don ƙara yawan kashi a cikin maza masu fama da osteoporosis na farko ko hypogonadal wadanda ke da haɗari ga karaya ko sun kasa ko kuma ba su da haƙuri ga wasu hanyoyin kwantar da hankali.
Bugu da ƙari, abaloparatide yana ba da fa'idodi ga duka maza da mata waɗanda ke da osteoporosis da ke da alaƙa da ci gaba na tsarin glucocorticoid far. Wadannan mutane suna cikin haɗari mai girma don karaya saboda amfani da glucocorticoids na dogon lokaci. Abaloparatide zai iya taimakawa wajen inganta ƙarfin kashi kuma ya rage haɗarin karaya a cikin wannan ƙayyadaddun yawan jama'a.
Abaloparatide, analog na roba na PTHrP, magani ne mai mahimmanci ga osteoporosis. Abubuwan da ake amfani da shi na anabolic suna inganta haɓakar kashi kuma suna ƙara yawan kashi, yana rage haɗarin karaya. Ana nuna shi ga mata da maza da suka shude a babban haɗari ga karaya, da kuma ga mutanen da suka kasa ko kuma ba su jure wa wasu hanyoyin maganin osteoporosis. Ta hanyar zaɓin kunna PTH1R, abaloparatide yana haifar da hanyar siginar anabolic wanda ke haɓaka lafiyar kashi. Yin amfani da shi a cikin osteoporosis da ke hade da ci gaba na tsarin tsarin glucocorticoid yana ba da wani zaɓi mai mahimmanci na jiyya ga mutane da ke da babban haɗari ga karaya. Abaloparatide yana taka muhimmiyar rawa wajen magance bukatun marasa lafiya tare da osteoporosis da inganta lafiyar kashi da ingancin rayuwa.
