0102030405
Bivalirudin: Mai hana Thrombin Mai Sauke don Ingantaccen Maganin Ciwon Jiki
Cikakken Bayani
Bivalirudin shine peptide saura 20 na roba wanda ke aiki azaman mai hanawa na thrombin, wani mahimmin enzyme wanda ke shiga cikin samuwar jini. Ta hanyar ɗaure zuwa wurin aiki na thrombin, bivalirudin yana hana juyar da fibrinogen zuwa fibrin, muhimmin mataki na samuwar thrombus. An yi amfani da shi ta hanyar jini, bivalirudin yana taka muhimmiyar rawa a cikin maganin rigakafi. Duk da haka, a hankali saka idanu na hematocrit, kunna partal thromboplastin lokaci (aPTT), na kasa da kasa daidaita rabo (INR), da kuma hawan jini ya zama dole saboda m iya sa jini stagnation.
Bivalirudin yana nuna tasirin hanawa akan duka mai narkewa da thrombus-daure thrombin in vitro. Mahimmanci, wannan tasirin hanawa ya kasance mara tasiri ta samfuran da aka fitar da platelet. Tare da hanyar dogaro da kashi, bivalirudin na iya tsawaita plasma aPTT, lokacin thrombin, da lokacin prothrombin a cikin abubuwan ɗan adam na yau da kullun. Waɗannan halayen sun sa ya dace musamman don amfani da shi wajen shiga tsakani na jijiyoyin jini (PCI) ga marasa lafiya tare da angina mara ƙarfi.
bugun jini na Cardioembolic, wanda kuma aka sani da bugun jini na zuciya, yana faruwa ne lokacin da emboli ya samo asali daga zuciya da baka na aortic suna tafiya ta cikin jini, wanda ke haifar da bugun jini na jijiya da kuma rashin aikin kwakwalwa na gaba. Ciwon zuciya na zuciya, idan aka kwatanta da bugun jini na ischemic na wasu cututtuka, yakan zama mafi rikitarwa dangane da dalilai masu mahimmanci, mafi tsanani game da gabatarwa, suna da mummunan hangen nesa, da kuma yawan sake dawowa. Kusan 70% na duk bugun jini da asalin zuciya ana danganta su da fibrillation (AF). Maganin maganin ƙwanƙwasa wanda ya dace da yanayin mai haƙuri yana da mahimmanci don rigakafin na biyu na bugun jini na zuciya na AF.
Lokacin yin la'akari da yin amfani da bivalirudin, yana da mahimmanci a tuna da buƙatun kulawa don ingantaccen lafiyar haƙuri. Canje-canje a cikin hematocrit, aPTT, INR, da hawan jini ya kamata a lura da su sosai don gano duk wata matsala mai yuwuwa da ke tattare da tashewar jini. Kulawa na yau da kullun yana ba masu sana'a na kiwon lafiya damar daidaita adadin kuma tabbatar da cewa majiyyaci yana karɓar matakin da ya dace na maganin rigakafi.
Bivalirudin, a matsayin mai hana thrombin mai jujjuyawar, yana taka muhimmiyar rawa a cikin maganin rigakafi. Ta hanyar hana thrombin, yana hana samuwar fibrin da samuwar jini na gaba. Wannan ya sa ya zama zaɓi mai tasiri don amfani da shi a cikin tsaka-tsakin jijiyoyin jini na percutaneous, musamman ga marasa lafiya tare da angina mara ƙarfi.
Idan kuna da wasu buƙatu masu alaƙa don Bivalirudin, don Allah kar ku yi shakka a tuntuɓe mu don farashi mafi kyau.
Idan kuna da wasu buƙatu masu alaƙa don Bivalirudin, don Allah kar ku yi shakka a tuntuɓe mu don farashi mafi kyau.
Ƙayyadaddun bayanai
