Cisplatin Foda Cisplatin Tsabta 99% Cisplatin Pharmaceutical

Sunan samfur Cisplatin
Bayyanar Orange-rawaya zuwa duhu rawaya crystalline foda
CAS No. 15663-27-1
Tsarin sinadarai Cl2H6N2Pt
Nauyin kwayoyin halitta 300.05
Wurin narkewa 270 ℃
Yawan yawa 3.7

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samfurin bayani

Cikakken Bayani

Cisplatin, wanda kuma aka sani da sunan kasuwancin sa Platinol, magani ne na chemotherapy da ake amfani dashi don magance nau'in ciwon daji daban-daban.

Bayyanar: Cisplatin fari ne zuwa fari-fari crystalline foda tare da wari mara kyau. Yana da ɗan narkewa a cikin ruwa amma yana narkewa a cikin mafita mai ɗauke da chloride da wasu abubuwan kaushi. Yanayin zafin jiki don kiyaye kwanciyar hankali.Idan aka adana shi da kyau, cisplatin yana kiyaye amincin sinadarai da ƙarfinsa. An fara haɗa shi a cikin 1844 da Alfred Werner, masanin kimiyar Switzerland wanda ya karɓi lambar yabo ta Nobel a Chemistry a 1913 saboda aikinsa na haɗin gwiwa.Cisplatin ya kasance. daga baya aka yi bincike akan abubuwan da zasu iya magance cutar kansa kuma an gano cewa yana da tasiri wajen magance cututtuka daban-daban.

Aiki da Aikace-aikace:Cisplatin an rarraba shi azaman maganin chemotherapy na tushen platinum kuma yana cikin dangin alkylating agents.Yana aiwatar da tasirin anticancer ta hanyar ƙirƙirar haɗin gwiwa tare da DNA, yana haifar da rushewar ayyukan salula kuma a ƙarshe yana haifar da mutuwar tantanin halitta. , Cisplatin yana ɗaure zuwa sansan purine a cikin DNA, yana samar da intrastrand da interstrand crosslinks.Wadannan hanyoyin haɗin gwiwar suna tsoma baki tare da kwafin DNA da rubutawa, yana haifar da hana yaduwar kwayar halitta da shigar da apoptosis a cikin ƙwayoyin kansa. nau'in ciwon daji, da suka hada da testicular, ovarian, mafitsara, kai da wuya, huhu, da sankarar mahaifa.

Yawancin lokaci yana cikin tsarin haɗin gwiwar chemotherapy kuma ana gudanar da shi ta hanyar jini a cikin asibiti a ƙarƙashin kulawar masu sana'a na kiwon lafiya.Haɗin cisplatin tare da sauran magungunan chemotherapeutic, irin su etoposide, bleomycin, da fluorouracil, ya nuna tasirin haɗin gwiwa a cikin maganin wasu magunguna. malignancies. Baya ga na farko rawar a cikin m ƙari malignancies, cisplatin kuma ana amfani da a cikin maganin germ cell ciwace-ciwacen daji, duka a matsayin daya wakili da kuma a hade tare da sauran chemotherapy magunguna.It ya nuna tasiri a cikin kula da metastatic testicular ciwon daji. musamman idan aka yi amfani da su tare da wasu abubuwan da ke tushen platinum irin su etoposide da bleomycin. Bugu da ƙari kuma, an yi nazarin cisplatin don yuwuwar aikace-aikacensa a cikin wasu nau'in ciwon daji, gami da ciwon daji na esophageal, na ciki, da ciwon daji na pancreatic.

Bincike ya ci gaba da gano ingancinsa a hade tare da novel niyya hanyoyin kwantar da hankali da kuma immunotherapies don haɓaka sakamakon jiyya da rage haɓakar juriya. Baya ga maganin ciwon daji, an kuma bincika cisplatin don yuwuwar amfani da shi a cikin maganin hyperthermia na gida, wanda ya haɗa da dumama takamaiman wuraren. jiki don kashe kwayoyin cutar kansa ko sanya su zama masu kula da wasu jiyya.A cikin wannan mahallin, ana amfani da cisplatin a hade tare da zafi don haɓaka tasirin cytotoxic a cikin ƙananan ƙwayoyin tumor.

A taƙaice, cisplatin magani ne na ƙwayar cuta na platinum na roba wanda ke yin tasirin maganin kansa ta hanyar samar da hanyoyin haɗin gwiwar DNA da haifar da mutuwar tantanin halitta a cikin ƙwayoyin kansa. Ciwon daji na mahaifa, tare da ci gaba da bincike da ke bincika yiwuwarsa a cikin wasu malignancies. Bugu da ƙari, cisplatin yana da aikace-aikacen da za a iya amfani da su a cikin maganin hyperthermia kuma ya ci gaba da kasancewa muhimmin bangare na tsarin haɗin gwiwar chemotherapy.