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Memantine HCl 99% Tsafta yana maganin Samar da Masana'antar Cutar Alzheimer
Cikakken Bayani
Memantine hydrochloride, wanda Merz ya kirkira a Jamus, wani sabon magani ne da aka yi niyya da farko don maganin ciwon hauka. Yana aiki azaman antagonist mai karɓa na N-methyl-D-aspartate (NMDA), yana toshe masu karɓar NMDA kuma yana rage haɓakar glutamate-induced hyperexcitability. Wannan tsarin yana nufin haɓaka aikin fahimi, hana apoptosis, da haɓaka ƙwaƙwalwar ajiya. Pethidine hydrochloride an amince da shi daga Kwamitin Turai don Kayayyakin Magunguna (CPMP) don magance matsananciyar cutar Alzheimer mai tsanani a cikin 2002. Ƙarin nazarin ya kuma nuna tasirinsa a cikin marasa lafiya da ƙananan cutar Alzheimer.
Memantine hydrochloride, sashi mai aiki a cikin pethidine hydrochloride, matsakaicin kusanci ne, mai adawa da mai karɓar NMDA mara gasa. Duk da yake aikace-aikacen sa na farko shine maganin cutar Alzheimer, an yi nazari sosai kuma an yi amfani da shi don wasu cututtuka na tsarin juyayi na tsakiya kamar su farfadiya, migraines, da yanayin tabin hankali ciki har da ciwon bipolar da schizophrenia. Dementia ya kasance babban abin da ake mayar da hankali kan aikace-aikacen memantine, kuma ya nuna fa'idodi daban-daban a cikin cutar Alzheimer, ciwon jijiya, da lalata tare da jikin Lewy. Ba wai kawai yana inganta aikin fahimi ba har ma yana magance alamun halayya da tunani na rashin hankali (BPSD), irin su hallucinations, ruɗi, tashin hankali, tashin hankali, da fushi.
Bugu da ƙari, tasirin da yake da shi a kan cutar hauka, an bincika memantine don tasirinsa akan wasu cututtuka na jijiyoyi. Marasa lafiya masu fama da farfaɗiya sukan fuskanci ƙarancin fahimi, kuma memantine ya nuna yuwuwar rage waɗannan gibin. Bugu da ƙari, cutar Alzheimer kanta abu ne mai haɗari ga kamewa, kuma mutanen da ke da cutar suna cikin haɗari mafi girma na kamuwa da farfadiya idan aka kwatanta da waɗanda ba tare da Alzheimer ba. Ta hanyar hana neuroexcitotoxicity da ke da alaƙa da haɓakawar mai karɓar NMDA, memantine na iya samun tasirin antiepileptik.
Bugu da ƙari kuma, an yi nazarin memantine a cikin mahallin maganin radiation na kwakwalwa gaba daya (WBRT), raunin kwakwalwa (TBI), da bugun jini. WBRT na iya haifar da rashin fahimta, kuma an nuna memantine yana jinkirta farawa da inganta aikin fahimi. Abubuwan da ke tattare da magunguna na musamman na memantine sun haifar da bincikensa a cikin nau'ikan cututtukan jijiyoyin jiki.
Nazarin baya-bayan nan sun ma ba da shawarar yuwuwar aikace-aikacen memantine a cikin rage tasirin neurotoxic na COVID-19 da hana kwafin ƙwayar cuta, yana nuna ƙimar aikin asibiti.
Memantine hydrochloride, musamman abin da ke aiki da shi memantine hydrochloride, ya nuna inganci a cikin maganin cutar hauka, musamman cutar Alzheimer. Tsarinsa na musamman a matsayin antagonist mai karɓa na NMDA yana ba da damar haɓakawa a cikin aikin fahimi da kuma kula da halayen halayya da tunanin mutum da ke da alaƙa da lalata. Bugu da ƙari, memantine yana nuna alƙawari a cikin wasu cututtuka na jijiyoyi irin su farfaɗo, migraines, da rashin lafiyar bayan-radiation. Ci gaba da bincike na ci gaba da gano yuwuwar darajar asibiti na memantine a cikin yanayi daban-daban na jijiya.
Ka tuna tuntuɓar mu don jagorar koshin lafiya.
Ka tuna tuntuɓar mu don jagorar koshin lafiya.
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