Rosuvastatin wakili na antilipemic Rosuvastatin yana magance dyslipidemia

Rosuvastatin yana hana enzyme hydroxymethylglutaryl-CoA reductase a cikin hanta, wanda ke rage haɗin cholesterol kuma yana rage ƙwayar cholesterol da matakan triglyceride. Bugu da ƙari, Rosuvastatin yana ƙara haɓakar hanta da rushewar ƙananan ƙwayoyin lipoprotein cholesterol (LDL-C), yayin da kuma yana haɓaka matakan cholesterol mai yawa na lipoprotein (HDL-C). Baya ga tasirinsa na rage lipid, an nuna Rosuvastatin yana da anti-atherosclerotic, anti-inflammatory, antioxidant, plaque stabilizing, da ingantattun kayan aikin endothelial.

Ana samar da Rosuvastatin ta hanyar fermentation na Aspergillus terreus ko ta hanyar haɗin sunadarai. Da zarar an ci shi, yana da yawa metabolized a cikin hanta kuma yana jujjuya zuwa metabolites daban-daban, gami da metabolites masu aiki waɗanda ke hana HMG-CoA reductase. Maganin da metabolites ɗinsa suna fitowa ne da farko a cikin najasa, tare da ɗan ƙaramin adadin da aka fitar a cikin fitsari.