ʻO Arecoline hydrobromide Therapeutic Potential i loko o ka ʻōnaehana nerve waena

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inoa mea kūʻai Arecoline
CAS No. 300-08-3
MF C8H14BrNO2
MW 236.109
EINECS 206-087-3
ʻO ka helu ʻakika (pka) 6.84(ma 25 ℃)
Lae hehee 171-175°C

Kāhea iā mā˚ou

nā kikoʻī huahana

Ka wehewehe kikoʻī

ʻO Arecoline, ka alkaloid ikaika nui i loaʻa i ka areca nut, ua loaʻa ka manaʻo no kona hiki ke hoʻōla i ka hoʻoponopono ʻana i nā maʻi psychiatric a me ka hoʻopau ʻana i nā maʻi ʻōpū. Ke manaʻo nei kēia ʻatikala e hāʻawi i kahi hōʻuluʻulu ʻōnaehana o ka hana o ka arecoline i nā ʻōnaehana kino like ʻole, e like me ka lua waha, ka ʻōnaehana nerve waena, ka ʻōnaehana cardiovascular, a me ka ʻōnaehana digestive. Eia kekahi, e ʻimi ʻia nā hana olakino a me nā hopena ʻona o ka arecoline. ʻO ka hope, e kūkākūkā ʻia nā noi o ka arecoline i nā meaʻai meaʻai olakino, nā lāʻau lapaʻau, a me nā hoʻomākaukau hoʻonaninani.

ʻO Arecoline, kahi alkaloid stimulant parasympathomimetic acid-nicotinic, hana nui ma ke ʻano he agonist ʻāpana o nā mea loaʻa muscarinic acetylcholine. Hōʻike ia i nā hopena parasympathetic ma mua o ka hōʻeha ʻana i ka nicotinic acetylcholine receptors like nicotine. Kāohi pū ʻo Arecoline i ka AMPK (adenosine monophosphate-activated protein kinase) ma o ka hana ʻana o nā ʻano oxygen reactive (ROS) i nā ʻano cell like ʻole.

Nā hopena ma nā ʻōnaehana kino like ʻole:

Pūnaehana Nervous: Paipai ʻo Arecoline i ka hauʻoli, hoʻonui i ke aʻo ʻana a me ka hoʻomanaʻo, a hoʻemi i nā hōʻailona o ke kaumaha a me ka schizophrenia. Hiki iā ia ke hoʻohuli i ka nalowale hoʻomanaʻo i hoʻokomo ʻia e ka scopolamine.

Pūnaehana Cardiovascular: Hana ʻo Arecoline ma ke ʻano he vasodilator, hoʻonui i ka plasma nitric oxide, eNos, a me ka hōʻike mRNA, a hōʻike i ka anti-thrombosis a me nā hopena anti-atherogenic. Hoʻohaʻahaʻa ia i ka IL-8 a me nā mea ʻē aʻe.

Pūnaehana Endocrine: Hoʻoulu ʻo Arecoline i nā pūnaewele o Leydig, e alakaʻi ana i ka piʻi ʻana o nā pae testosterone. Hoʻoulu ia i ka axis hypothalamic-pituitary-adrenal (HPA), hoʻoulu i ka hoʻokuʻu ʻana o ka corticotropin-releasing hormone (CRH). Eia kekahi, kōkua ia i ka pale ʻana i ka hana ʻole o nā pancreatic beta cell i hoʻokumu ʻia e ka nui o ka fructose intake.

Pūnaehana Digestive: Hoʻoulu ʻo Arecoline i ka ʻōnaehana digestive ma o ka hoʻāla ʻana o nā mea hoʻokipa muscarinic. Hoʻonui ia i ka ʻokiʻoki ʻana o ka ʻiʻo maʻemaʻe o ka ʻōpū a me nā ʻāpana ʻiʻo o ka duodenum, ileum, a me ke kolonā.

Nā hana olakino a me nā noi:

Analgesia a me Central Nervous System Effects: Arecoline hydrobromide e hōʻike ana i nā waiwai analgesic a he hopena hoʻokūpaʻa i ka ʻōnaehana nerve waena.

Ola Ola: Hoʻoikaika ʻo Arecoline hydrobromide i ka metabolism ʻili a hōʻike i ka hiki ke mālama i nā maʻi ʻili a me nā maʻi ʻili ʻē aʻe.

Detoxification a me nā hopena diuretic: ʻo Arecoline hydrobromide e hoʻomaʻemaʻe i ka wela, hoʻomaʻemaʻe, hoʻopau i ka maʻemaʻe a me ka pehu, a he waiwai diuretic.

Antibacterial and Dissolving Stones: Arecoline hydrobromide hōʻike i nā waiwai antibacterial a me ka hiki ke hoʻoheheʻe i nā pōhaku.

ʻO ka hoʻoikaika ʻana i ke koko a me ke kahe koko: ʻo Arecoline hydrobromide e kōkua i ka hoʻoikaika ʻana i nā kīʻaha koko a hoʻoikaika i ke kahe koko.

Nā noi:

Nā Meaʻai Meaʻai Ola: Hiki ke hoʻohana ʻia ʻo Arecoline ma ke ʻano he mea hoʻohui i nā meaʻai olakino e kuhikuhi ana i nā hana olakino kūikawā, e like me ka hoʻonui cognitive a i ʻole ke olakino ʻili.

Lapaʻau Lapaʻau: Loaʻa paha i ka Arecoline nā noi i nā lāʻau lapaʻau, ʻoi aku ka maikaʻi o ka mālama ʻana i nā maʻi psychiatric a i ʻole he lāʻau antihelmintic.

Hoʻomākaukau Mea Hoʻomaʻamaʻa: ʻO ka hoʻoikaika ʻana i ka metabolism ʻili o Arecoline a me nā waiwai hoʻōla ʻeha e lilo ia i moho no ka hoʻomākaukau ʻana i nā mea hoʻomaʻemaʻe, ʻoi aku ka poʻe e ʻimi nei i nā maʻi ʻili a i ʻole nā maʻi pili i ka ʻili.

ʻO Arecoline, ka alkaloid ikaika i loaʻa i ka areca nut, hōʻike i nā hopena lapaʻau like ʻole a loaʻa nā noi i nā ʻōnaehana kino like ʻole. Hoʻopili mua ʻia kāna mau hana ma o ka muscarinic receptors a hōʻike i nā hopena parasympathetic. ʻOiai e hōʻike ana ʻo arecoline i ka ʻōlelo hoʻohiki i ka hoʻoponopono ʻana i kekahi mau kūlana olakino, pono ia e noʻonoʻo i nā hopena ʻona a me nā waiwai carcinogenic e pili ana i ka hoʻohana ʻana. E kelepona me mākou inā pono.

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