ʻO Rosuvastatin antilipemic agent Rosuvastatin e mālama i ka dyslipidemia

Kāohi ʻo Rosuvastatin i ka enzyme hydroxymethylglutaryl-CoA reductase i loko o ke ake, kahi e hōʻemi ai i ka synthesis cholesterol a hoʻohaʻahaʻa i ka cholesterol serum a me nā pae triglyceride. Eia kekahi, hoʻonui ka Rosuvastatin i ka lawe ʻana a me ka haki ʻana o ka lipoprotein cholesterol haʻahaʻa haʻahaʻa (LDL-C), aʻo ka hoʻonui ʻana i nā kiʻekiʻe o ka lipoprotein cholesterol kiʻekiʻe (HDL-C). Ma kahi o kāna mau hopena hoʻohaʻahaʻa lipid, ua hōʻike ʻia ʻo Rosuvastatin i ka anti-atherosclerotic, anti-inflammatory, antioxidant, plaque stabilizing, a me ka hoʻomaikaʻi ʻana i nā waiwai hana endothelial.

Hana ʻia ʻo Rosuvastatin ma o ka fermentation o Aspergillus terreus a i ʻole ma o ka synthesis kemika. I ka manawa e ʻai ʻia ai, ua hoʻololi nui ʻia i loko o ke akepaʻa a hoʻololi ʻia i nā metabolites like ʻole, me nā metabolites ikaika e kāohi ai i ka HMG-CoA reductase. ʻO ka lāʻau lapaʻau a me kāna mau metabolites e hoʻokuʻu mua ʻia i nā feces, me kahi liʻiliʻi i hoʻokuʻu ʻia i loko o ka mimi.