0102030405
Vincristine Sulfate Pauda Vincristine Purity Vincristine CAS 57-22-7
Ka wehewehe kikoʻī
ʻO Vincristine he keʻokeʻo a keʻokeʻo keʻokeʻo crystalline pauka. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai, akā hoʻoheheʻe ia i kekahi mau mea hoʻoheheʻe organik. He alkaloid kūlohelohe ia i loaʻa mai ka mea kanu periwinkle Madagascar (Catharanthus roseus). Ua like kona ʻano kemika me ka vinblastine, kekahi alkaloid vinca. Hoʻohana nui ʻia ʻo Vincristine i ka mālama ʻana i nā ʻano maʻi maʻi like ʻole, me ka leukemia, lymphoma, a me nā maʻi koko paʻa. .
ʻO Vincristine kahi mea hoʻopaneʻe microtubule e hoʻopau i ka hoʻokumu ʻana o nā microtubules, ʻo ia nā mea koʻikoʻi o ka cytoskeleton o ka cell. ʻO ka vincristine ka mea maikaʻi loa e kūʻē i ka puʻunaue wikiwiki ʻana i nā pūnaʻi maʻi maʻi. i hui pū ʻia me nā lāʻau chemotherapeutic ʻē aʻe ma ke ʻano he ʻāpana o nā regimens lapaʻau multi-drug, i hui pū ʻia ʻo ka chemotherapy hui.
Ma kahi o kāna hoʻohana mua ʻana i ka mālama ʻana i ka maʻi kanesa, ua hōʻike pū ʻo vincristine i ka maikaʻi i ka mālama ʻana i kekahi mau kūlana non-oncological. , ua hōʻike ʻo vincristine i ka hiki ke mālama i nā maʻi neurological like ʻole, me ka polyneuropathy demyelinating maʻi maʻi (CIDP) a me nā maʻi neuropsychiatric autoimmune pediatric e pili ana i nā maʻi streptococcal (PANDAS).
Eia kekahi, ua alakaʻi nā waiwai anti-angiogenic o vincristine i ka ʻimi ʻana i kāna hiki ke hoʻohana i ka mālama ʻana i nā maʻi proliferative like ʻole, me ka retinopathy diabetic a me ka degeneration macular e pili ana i ka makahiki. ʻO nā kūlana olakino ʻē aʻe i manaʻo ʻia he off-label a koi i ka loiloi akahele o nā pilikia a me nā pōmaikaʻi. ʻO nā noiʻi lapaʻau ākea e pili ana i ka mālama ʻana i ka maʻi leukemia, lymphoma, nā ʻōpū paʻa, a me kekahi mau kūlana non-oncological.
Hōʻike
