Kev yug ntxov ntxov ua rau muaj kev pheej hmoo loj thiab lub nra hnyav rau ob tsev neeg thiab tib neeg tag nrho. Yog li ntawd, kev tiv thaiv thiab kho kev yug ntxov ntxov yog qhov tseem ceeb tshaj plaws. Tocolytics, xws li atosiban, ua lub luag haujlwm tseem ceeb hauv kev ncua kev ua haujlwm ua ntej yug menyuam thiab tiv thaiv tus menyuam hauv plab. Atosiban, cyclic nonapeptide thiab oxytocin analogue, ua raws li kev sib tw antagonist ntawm oxytocin receptors hauv tsev menyuam, decidua, thiab fetal membranes. Los ntawm inhibiting uterine contractions, atosiban tau tshwm sim los ua cov cuab yeej kho mob tseem ceeb hauv kev kho mob yug ntxov ntxov.
Atosiban, ua ke ua ke oxytocin thiab vasopressin V1A receptor antagonist, muaj txoj hauv kev tshwj xeeb rau inhibiting uterine contractions. Cov txheej txheem zoo sib xws ntawm oxytocin receptor thiab vasopressin V1A receptor yuav tsum muaj kev cuam tshuam ib txhij ntawm ob txoj hauv kev receptor kom zoo inhibit uterine contractions. Tsis zoo li lwm yam tocolytics xws li beta-agonists, calcium channel blockers, thiab prostaglandin synthase inhibitors, atosiban's dual receptor antagonism tso cai rau kom muaj txiaj ntsig zoo ntawm kev ua haujlwm ntawm lub tsev menyuam. Oxytocin, ntxiv rau stimulating uterine contractions, kuj stimulates zus tau tej cov thiab tso tawm ntawm PGF2α, uas ntxiv txhawb rau uterine smooth nqaij contraction. Atosiban lub siab affinity rau oxytocin thiab vasopressin V1A receptors sib tw khi rau cov receptors, zoo thaiv txoj hauv kev ntawm oxytocin thiab vasopressin. Cov txheej txheem no ua rau txo qis hauv uterine contractions.
Ib qho txiaj ntsig tseem ceeb ntawm atosiban yog nws cov kev mob tshwm sim tsawg heev. Thaum me tachycardia, lub hauv siab nruj, kiv taub hau, mob taub hau, xeev siab, thiab dyspnea tau raug tshaj tawm, cov kev mob tshwm sim no feem ntau yuav tsum tsis muaj kev kho tshwj xeeb, thiab cov tshuaj tsis tshua raug txiav tawm vim muaj kev phiv. Tsis tas li ntawd, atosiban muaj cov ntshav plasma luv ib nrab-lub neej, txwv tsis pub nws tsub zuj zuj hauv cov menyuam hauv plab thiab txo qhov kev pheej hmoo ntawm kev tsis zoo ntawm tus menyuam hauv plab. Hauv ntau qhov chaw, ob qhov muag tsis pom kev, kev sim tshuaj placebo, kev kho mob atosiban ua rau lub cev xeeb tub ntev txog 7 hnub. Cov kev sim tshuaj sib piv kuj tau pom tias atosiban muaj qhov sib piv tocolytic ua rau ritodrine thaum ua tau zoo dua, tshwj xeeb tshaj yog cov kev mob tshwm sim ntawm niam txiv. Cov kev tshawb pom no qhia txog qhov muaj peev xwm ntawm atosiban ua tus neeg sawv cev zoo thiab tocolytic.
Atosiban, raws li kev sib tw vasopressin / oxytocin receptor antagonist, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev yug ntxov ntxov. Nws lub peev xwm los inhibit uterine contractions los ntawm dual receptor antagonism ua rau nws yog ib qho cuab yeej tseem ceeb rau ncua kev ua hauj lwm ua ntej. Cov kev mob tshwm sim tsawg kawg nkaus, luv luv plasma ib nrab-lub neej, thiab kev txwv tsis pub nkag rau hauv lub plab hauv plab ntxiv txhim kho nws qhov kev nyab xeeb. Tsis tas li ntawd, atosiban lub peev xwm los txhim kho qhov tshwm sim ntawm cev xeeb tub hauv cov neeg mob uas muaj kev cog lus rov qab tsis ua haujlwm hauv IVF-ET qhia tau tias nws muaj peev xwm ua tau zoo thiab muaj peev xwm hauv cov tshuaj tua menyuam. Kev tshawb fawb txuas ntxiv thiab kev siv tshuaj kho mob ntawm atosiban tuaj yeem pab txo qis lub nra ntawm kev yug ntxov ntxov ntawm tsev neeg thiab zej zog.
