Cisplatin Hmoov Cisplatin Purity 99% Cisplatin Pharmaceutical

Khoom npe Cisplatin
Qhov tshwm sim Txiv kab ntxwv-daj rau tsaus daj crystalline hmoov
CAS Nr. 15663-27-1
Tshuaj Formula Cl2H6N2 Pt
Molecular hnyav 300.05 Nws
Melting point 270 ℃
Qhov ntom 3.7

Tiv tauj peb

cov khoom paub meej

Cov lus piav qhia ntxaws

Cisplatin, tseem paub los ntawm nws lub npe lag luam Platinol, yog cov tshuaj khomob uas siv los kho ntau hom mob qog noj ntshav.

Cov tsos mob: Cisplatin yog cov hmoov dawb mus rau dawb crystalline hmoov nrog cov yam ntxwv tsis hnov tsw.Nws yog soluble nyob rau hauv dej tab sis dissolves nyob rau hauv chloride-muaj cov ntsiab lus thiab ib co organic solvents.Cov ntshiab compound feem ntau yog khaws cia nyob rau hauv qhuav, tsaus qhov chaw nyob rau hauv kev tswj. Thaum khaws cia kom zoo, cisplatin tswj nws cov tshuaj lom neeg kev ncaj ncees thiab muaj zog.Nws yog thawj zaug tsim nyob rau hauv 1844 los ntawm Alfred Werner, ib tug Swiss chemist uas tau txais Nobel nqi zog nyob rau hauv Chemistry nyob rau hauv 1913 rau nws ua hauj lwm ntawm kev sib koom ua ke.Cisplatin yog Tom qab tshawb xyuas rau nws cov peev xwm tiv thaiv kab mob qog noj ntshav thiab pom tias muaj txiaj ntsig zoo hauv kev kho mob ntawm ntau yam malignancies.

Kev Ua Haujlwm thiab Kev Siv: Cisplatin yog cais raws li cov tshuaj siv tshuaj kho mob platinum thiab yog ib feem ntawm tsev neeg ntawm cov tshuaj alkylating.Nws ua rau nws cov tshuaj tiv thaiv kab mob los ntawm kev tsim covalent bonds nrog DNA, ua rau muaj kev cuam tshuam ntawm cellular zog thiab thaum kawg ua rau cell tuag. , cisplatin khi rau purine hauv paus hauv DNA, tsim intrastrand thiab interstrand crosslinks.Cov crosslinks cuam tshuam nrog DNA replication thiab transcription, ua rau inhibition ntawm cell proliferation thiab induction ntawm apoptosis nyob rau hauv cov qog nqaij hlav cancer.Cisplatin yog dav siv nyob rau hauv kev kho mob ntawm ntau yam. hom mob qog noj ntshav, nrog rau cov qog nqaij hlav, zes qe menyuam, zais zis, taub hau thiab caj dab, ntsws, thiab mob qog noj ntshav.

Nws feem ntau yog ib feem ntawm kev siv tshuaj khomob sib xyaw ua ke thiab tau muab tso rau hauv qhov chaw kho mob raws li kev saib xyuas ntawm cov kws kho mob.Kev sib xyaw ntawm cisplatin nrog rau lwm cov tshuaj kws khomob, xws li etoposide, bleomycin, thiab fluorouracil, tau pom muaj kev sib koom ua ke hauv kev kho mob ntawm qee yam. Ntxiv nrog rau nws lub luag haujlwm tseem ceeb hauv cov qog nqaij hlav malignancies, cisplatin kuj tseem siv los kho cov kab mob qog nqaij hlav, ob leeg ua ib tus neeg sawv cev thiab ua ke nrog lwm cov tshuaj siv tshuaj kho mob. tshwj xeeb tshaj yog thaum siv ua ke nrog lwm cov tshuaj platinum xws li etoposide thiab bleomycin. Tsis tas li ntawd, cisplatin tau kawm txog nws cov peev xwm siv rau lwm hom mob qog noj ntshav, nrog rau cov kab mob hauv plab, plab, thiab mob qog noj ntshav.

Kev tshawb fawb txuas ntxiv mus tshawb nrhiav nws cov txiaj ntsig ua ke nrog cov kev kho tshiab thiab cov tshuaj tiv thaiv kab mob txhawm rau txhim kho cov txiaj ntsig kev kho mob thiab txo qhov kev txhim kho ntawm kev tiv thaiv.Tshwj xeeb ntawm kev kho mob qog noj ntshav, cisplatin kuj tau tshawb xyuas rau nws cov peev xwm siv hauv kev kho mob hyperthermia hauv zos, uas suav nrog cov cua sov tshwj xeeb ntawm thaj chaw. Lub cev tua cov qog nqaij hlav cancer lossis ua rau lawv nkag siab rau lwm yam kev kho mob.Nyob rau hauv cov ntsiab lus no, cisplatin yog siv ua ke nrog cov cua sov los txhim kho nws cov teebmeem cytotoxic hauv cov qog microenvironment.

Hauv cov ntsiab lus, cisplatin yog cov tshuaj siv hluavtaws platinum-raws li kws khomob uas ua rau nws cov teebmeem tshuaj tiv thaiv kabmob los ntawm kev tsim DNA crosslinks thiab ua rau cov cell tuag hauv cov kabmob kheesxaws. Cov qog nqaij hlav hauv tsev menyuam, nrog rau kev tshawb fawb tsis tu ncua tshawb nrhiav nws cov peev xwm hauv lwm yam malignancies. Tsis tas li ntawd, cisplatin muaj peev xwm siv tau rau hauv kev kho mob hyperthermia thiab tseem yog ib qho tseem ceeb ntawm kev siv tshuaj khomob ua ke.