Ritonavir Cov Khoom Muag Zoo Tshaj Plaws Anti-Virus
Cov lus piav qhia ntxaws
Ritonavir, tshuaj tiv thaiv kab mob, feem ntau yog siv ua ke nrog lwm cov tshuaj los kho HIV / AIDS. Qhov kev sib xyaw ua ke no, hu ua kev siv tshuaj tiv thaiv kab mob siab heev (HAART), tau ua pov thawj zoo hauv kev tswj tus mob. Ritonavir yog cais raws li protease inhibitor, tab sis nws lub luag haujlwm tseem ceeb tam sim no yog los txhawb lub zog ntawm lwm cov protease inhibitors.
Ntxiv rau nws siv hauv kev kho mob HIV / AIDS, ritonavir kuj tau siv ua ke nrog lwm cov tshuaj los kho tus kab mob siab C thiab, tsis ntev los no, COVID-19. Nws yog noj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj los yog capsules. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias bioavailability ntawm ritonavir ntsiav tshuaj thiab cov tshuaj ntsiav yuav txawv, nrog rau cov ntsiav tshuaj muaj peev xwm ua rau siab dua cov ntshav plasma concentrations. Ritonavir ua raws li inhibitor ntawm HIV protease enzyme, cuam tshuam lub voj voog ntawm tus kab mob. Txawm hais tias pib tsim los ua ib tus neeg sawv cev tiv thaiv kab mob, nws tau pom tias muaj txiaj ntsig zoo dua thaum siv hauv kev sib xyaw ua ke nrog cov tshuaj qis ritonavir thiab lwm yam protease inhibitors. Niaj hnub no, nws yog feem ntau siv los ua ib qho kev txhawb nqa ntawm lwm cov protease inhibitors. Nws muaj nyob rau hauv ob qho tib si kua formulation thiab li capsules.
Daim ntawv thov tseem ceeb ntawm ritonavir yog nyob rau hauv kev kho mob ntawm cov neeg mob HIV, tshwj xeeb tshaj yog hom 1, uas yog qhov txaus ntshai thiab kis kab mob. Nws feem ntau ua ke nrog lwm cov tshuaj tiv thaiv kab mob hu ua lopinavir txhawm rau txhim kho kev kho mob. Lopinavir thiab ritonavir ua haujlwm ua ke los tiv thaiv thiab txo qis kev tsim cov kab mob HIV hauv lub cev. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nkag siab tias lopinavir thiab ritonavir tsis yog kev kho mob rau HIV thiab tsis txhob tiv thaiv kev kis tus kab mob ntawm ib tus neeg mus rau lwm tus.
Thaum siv ua ke nrog lwm cov tshuaj HIV, ritonavir pab tswj tus kab mob HIV los ntawm kev txo cov kab mob HIV hauv lub cev. Qhov no, nyob rau hauv lem, txhim kho kev ua hauj lwm ntawm lub cev tiv thaiv kab mob, txo cov kev pheej hmoo ntawm cov teeb meem thiab txhim kho tag nrho cov zoo ntawm lub neej. Ritonavir belongs rau chav kawm ntawm protease inhibitors thiab ua haujlwm los ntawm kev nce qib ntawm lwm cov protease inhibitors, yog li txhim kho lawv cov txiaj ntsig.Nws yog ib qho tseem ceeb rau cov neeg mob kom paub tias ritonavir tsis kho tus kab mob HIV. Txhawm rau txo qhov kev pheej hmoo ntawm kev kis tus kab mob, nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov tshuaj tiv thaiv kab mob HIV. Tsis tas li ntawd, siv txoj hauv kev zoo xws li cov hnab yas yas lossis polyurethane hnab looj tes thaum muaj kev sib deev thiab zam kev sib koom ntawm cov khoom ntiag tug uas tuaj yeem nkag mus rau hauv cov ntshav lossis cov kua hauv lub cev yog qhov tseem ceeb ceev faj.
Keeb kwm tsim los ua tus inhibitor ntawm HIV protease, ritonavir yog tam sim no tsis tshua siv rau nws tus kheej cov tshuaj tiv thaiv kab mob. Hloov chaw, nws yog dav siv ua ib qho kev txhawb nqa ntawm lwm cov protease inhibitors. Ritonavir inhibits ib qho enzyme hu ua cytochrome P450-3A4 (CYP3A4), uas yog lub luag haujlwm rau metabolizing protease inhibitors. Los ntawm kev khi rau thiab inhibiting CYP3A4, ritonavir ua rau qis dua ntawm lwm cov tshuaj tiv thaiv protease yuav tsum tau siv, txhim kho lawv cov txiaj ntsig thiab txo cov kev tsis zoo. Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias qhov inhibition ntawm CYP3A4 tseem tuaj yeem cuam tshuam qhov kev ua tau zoo ntawm lwm cov tshuaj, ua rau muaj kev nyuaj siab thaum muab tshuaj ib txhij.
Hauv cov ntsiab lus, ritonavir yog ib qho tseem ceeb ntawm kev kho mob HIV / AIDS, ua haujlwm raws li protease inhibitor thiab txhawb nqa ntawm lwm yam protease inhibitors. Nws txoj kev siv tseem ceeb yog hauv kev kho mob HIV, tshwj xeeb yog Hom 1. Thaum nws pab tswj kev kis tus kab mob HIV thiab txhim kho lub neej zoo, nws tsis yog kev kho thiab tsis tiv thaiv kev kis tus kab mob. Kev nkag siab txog cov tshuaj ua haujlwm thiab ua raws li cov txheej txheem kho mob tau sau tseg yog qhov tseem ceeb rau kev tswj tus mob kom zoo.
Hauv cov ntsiab lus, ritonavir yog ib qho tseem ceeb ntawm kev kho mob HIV / AIDS, ua haujlwm raws li protease inhibitor thiab txhawb nqa ntawm lwm yam protease inhibitors. Nws txoj kev siv tseem ceeb yog hauv kev kho mob HIV, tshwj xeeb yog Hom 1. Thaum nws pab tswj kev kis tus kab mob HIV thiab txhim kho lub neej zoo, nws tsis yog kev kho thiab tsis tiv thaiv kev kis tus kab mob. Kev nkag siab txog cov tshuaj ua haujlwm thiab ua raws li cov txheej txheem kho mob tau sau tseg yog qhov tseem ceeb rau kev tswj tus mob kom zoo.
Specification
