Vincristine Sulfate Hmoov Vincristine Purity Vincristine CAS 57-22-7
Cov lus piav qhia ntxaws
Vincristine yog ib qho dawb mus rau dawb crystalline hmoov.Nws yog suab insoluble nyob rau hauv dej, tab sis nws dissolves nyob rau hauv ib co organic solvents.Cov ntshiab compound yog odorless thiab yog feem ntau khaws cia nyob rau hauv ib tug qhuav, tsaus qhov chaw nyob rau hauv kev tswj kub tej yam kev mob kom nws stability. Nws yog ib qho alkaloid tshwm sim los ntawm Madagascar periwinkle tsob nroj (Catharanthus roseus).Nws cov qauv tshuaj zoo ib yam li vinblastine, lwm yam vinca alkaloid.Vincristine yog dav siv nyob rau hauv kev kho mob ntawm ntau yam mob qog noj ntshav, nrog rau cov kab mob leukemia, lymphoma, thiab cov qog nqaij hlav. .
Vincristine yog ib qho microtubule inhibitor uas cuam tshuam qhov tsim ntawm microtubules, uas yog cov khoom tseem ceeb ntawm lub cell cytoskeleton.Los ntawm kev khi rau tubulin, nws tiv thaiv kev sib sau ntawm microtubules, ua rau mitotic ntes thiab cell tuag nyob rau hauv nquag faib hlwb. Vincristine tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau kev faib cov qog nqaij hlav sai sai.Clinical applications ntawm vincristine suav nrog kev kho mob ntawm ntau yam malignancies xws li mob lymphoblastic leukemia (TAG NRHO), Hodgkin's thiab non-Hodgkin's lymphomas, menyuam yaus thiab cov neeg laus cov qog nqaij hlav, neuroblastoma, thiab rhabdomyosarcoma.Vincristine feem ntau siv. ua ke nrog lwm cov tshuaj chemotherapeutic uas yog ib feem ntawm kev kho mob ntau yam tshuaj, suav ua ke hu ua kev sib xyaw ua ke chemotherapy.
Ntxiv rau nws qhov kev siv tseem ceeb hauv kev kho mob qog noj ntshav, vincristine kuj tau pom tias muaj txiaj ntsig zoo hauv kev tswj hwm ntawm qee yam uas tsis yog oncological.Nws yog siv rau hauv kev kho mob ntawm idiopathic thrombocytopenic purpura (ITP), ib qho kab mob autoimmune uas muaj cov platelet tsawg. Tsis tas li ntawd. ,vincristine tau pom muaj peev xwm hauv kev tswj hwm ntawm ntau yam mob paj hlwb, suav nrog kev mob ntev ntev demyelinating polyneuropathy (CIDP) thiab cov kab mob autoimmune neuropsychiatric cuam tshuam nrog cov kab mob streptococcal (PANDAS).
Tsis tas li ntawd, Vincristine's anti-angiogenic thaj chaw tau ua rau kev tshawb fawb txog nws cov peev xwm siv hauv kev kho mob ntawm ntau yam kab mob proliferative, suav nrog ntshav qab zib retinopathy thiab hnub nyoog ntsig txog macular degeneration.Txawm li cas los xij, Vincristine feem ntau paub txog nws lub luag haujlwm hauv kev kho mob qog noj ntshav, thiab nws siv nyob rau hauv. Lwm yam kev kho mob yog suav hais tias yog off-label thiab yuav tsum tau ua tib zoo soj ntsuam ntawm tej zaum yuav txaus ntshai thiab cov txiaj ntsig.Nyob rau hauv cov ntsiab lus, Vincristine, muab los ntawm Madagascar periwinkle nroj tsuag, yog ib tug muaj txiaj ntsim anti-cancer tus neeg saib xyuas uas cuam tshuam microtubule tsim thiab induces cell tuag nyob rau hauv faib hlwb. Kev siv dav hauv kev kho mob suav nrog kev kho mob leukemia, lymphoma, cov qog nqaij hlav, thiab qee yam tsis yog oncological mob.Thaum nws siv thawj zaug hauv kev kho mob qog noj ntshav, kev tshawb fawb txuas ntxiv mus tshawb nrhiav nws cov peev xwm hauv ntau hom kev kho mob.
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