Abaloparatide, nke a na-ere n'okpuru aha aha Tymlos, bụ analog synthetic nke protein metụtara hormone parathyroid (PTHrP). Ọ bụ onye na-ahụ maka anabolic nke a na-eji agwọ osteoporosis, ọnọdụ nke ọkpụkpụ na-esighị ike na-eme ka ọkpụkpụ na-enwewanye ihe ize ndụ nke mgbaji. A na-egosi Abaloparatide maka ụmụ nwanyị postmenopausal na ndị nwoke nwere osteoporosis nwere nnukwu ihe ize ndụ maka mgbaji, yana maka ndị dara ada ma ọ bụ na-anabataghị ọgwụgwọ osteoporosis ndị ọzọ dịnụ. Site n'ịhọrọ ịgbalite parathyroid hormone 1 receptor (PTH1R), abaloparatide na-akwalite uto ọkpụkpụ ma na-abawanye njupụta ọkpụkpụ.
Abaloparatide bụ 34 amino acid synthetic analog nke PTHrP, yana 41% homology na parathyroid hormone (PTH) (1-34) na 76% homology na PTHrP (1-34). Usoro ọrụ ya gụnyere ijikọ na PTH1R, ihe nnabata protein jikọtara ọnụ nke G gosipụtara na osteoblasts na osteocytes. Site na ijikọ nke ọma na steeti conformational RG nke PTH1R, abaloparatide na-ewepụta nzaghachi mgbaàmà AMP na-agafe agafe, na-eduga na ụzọ mgbama anabolic.
N'ime ụmụ nwanyị postmenopausal nwere osteoporosis nwere nnukwu ihe ize ndụ maka mgbaji, abaloparatide bụ nhọrọ ọgwụgwọ dị irè. Ọ na-enyere aka ịbawanye ọkpụkpụ ọkpụkpụ ma belata ihe ize ndụ nke mgbaji. Tụkwasị na nke a, enwere ike iji abaloparatide mee ka ọkpụkpụ ọkpụkpụ dịkwuo n'ime ndị ikom nwere isi ma ọ bụ hypogonadal osteoporosis bụ ndị nwere nnukwu ihe ize ndụ maka mgbaji ma ọ bụ daa ma ọ bụ na-anabataghị ọgwụgwọ ndị ọzọ dịnụ.
Ọzọkwa, abaloparatide na-enye uru maka ma ndị nwoke ma ndị nwanyị nwere osteoporosis jikọtara ya na usoro ọgwụgwọ glucocorticoid na-adịgide adịgide. Ndị a nọ n'ihe ize ndụ dị ukwuu maka mgbaji n'ihi iji glucocorticoids ogologo oge. Abaloparatide nwere ike inye aka melite ike ọkpụkpụ ma belata ihe ize ndụ mgbaji na ọnụ ọgụgụ a.
Abaloparatide, analog synthetic nke PTHrP, bụ ọgwụgwọ bara uru maka osteoporosis. Njirimara anabolic ya na-akwalite uto ọkpụkpụ ma na-abawanye njupụta ọkpụkpụ, na-ebelata ihe ize ndụ nke mgbaji. E gosipụtara ya maka ụmụ nwanyị postmenopausal na ụmụ nwoke nwere nnukwu ihe ize ndụ maka mgbaji, yana maka ndị dara ada ma ọ bụ na-anabataghị ọgwụgwọ osteoporosis ndị ọzọ. Site na ịhọrọ PTH1R, abaloparatide na-ebute ụzọ mgbaàmà anabolic nke na-eme ka ahụike ọkpụkpụ dịkwuo mma. Ojiji ya na osteoporosis jikọtara ya na usoro ọgwụgwọ glucocorticoid na-adịgide adịgide na-enye nhọrọ ọgwụgwọ dị mkpa maka ndị mmadụ n'otu n'otu nwere nnukwu ihe ize ndụ maka mgbaji. Abaloparatide na-ekere òkè dị ukwuu n'igbo mkpa nke ndị ọrịa nwere osteoporosis na ime ka ọkpụkpụ ha dịkwuo mma na ndụ ndụ.
