Arecoline hydrobromide nwere ike ịgwọ ọrịa na sistemụ ụjọ Central

Ọnụ ego ntụaka: USD15-20/g

Aha ngwaahịa Arecoline
CAS Mba. 300-08-3
MF C8H14BrNO2
MW 236.109
EINECS 206-087-3
Ọnụọgụ acidity (pka) 6.84 (na 25 ℃)
Ebe mgbaze 171-175°C

Kpọtụrụ anyị

nkọwa ngwaahịa

Nkọwa zuru ezu

Arecoline, bụ isi alkaloid na-arụ ọrụ nke a na-achọta na akị areca, enwetala nlebara anya maka ike ọgwụgwọ ya n'ịgbasa ọrịa mgbaka na ibelata ọrịa eriri afọ. Edemede a bu n'obi inye nchịkọta nhazi usoro nke usoro nke arecoline na sistemu anụ ahụ dị iche iche, gụnyere oghere ọnụ, sistem ụjọ nke etiti, sistem obi obi, na sistem digestive. Na mgbakwunye, a ga-enyocha ọrụ ahụike yana mmetụta nsị nke arecoline nwere. N'ikpeazụ, a ga-atụle ngwa nke arecoline na mgbakwunye nri ahụike, ọgwụ, na nkwadebe ịchọ mma.

Arecoline, ihe nicotinic acid nke dabere na parasympatomimetic dị nro na-akpali akpali alkaloid, na-emebu dị ka agonist akụkụ nke muscarinic acetylcholine receptors. Ọ na-egosipụta mmetụta parasympathetic kama ịka ahụhụ nicotinic acetylcholine nnabata dị ka nicotine. Arecoline na-egbochikwa AMPK (adenosine monophosphate-activated protein kinase) site na ọgbọ nke ụdị oxygen reactive (ROS) na ụdị sel dị iche iche.

Mmetụta na sistemu ahụ dị iche iche:

Sistemụ Nri: Arecoline na-akwalite mkpali, na-eme ka mmụta na ebe nchekwa dịkwuo elu, ma na-ebelata mgbaàmà nke ịda mbà n'obi na schizophrenia. Ọ nwekwara ike weghaa mfu ebe nchekwa nke scopolamine kpatara.

Sistemụ Cardiovascular: Arecoline na-arụ ọrụ dị ka vasodilator, na-abawanye plasma nitric oxide, eNos, na okwu mRNA, ma gosipụta mgbochi thrombosis na mmetụta anti-atherogenic. Ọ na-ebelata IL-8 na ihe ndị ọzọ.

Sistemụ Endocrine: Arecoline na-akpali mkpụrụ ndụ Leydig, na-eduga n'ọkwa testosterone. Ọ na-arụ ọrụ hypothalamic-pituitary-adrenal (HPA) axis, na-akpali mmepụta nke corticotropin na-ahapụ hormone (CRH). Na mgbakwunye, ọ na-enyere aka igbochi arụ ọrụ nke mkpụrụ ndụ beta nke pancreatic site na oriri fructose dị elu.

Sistemụ nri nri: Arecoline na-akpali usoro nri nri site na ịgbalite ndị na-anabata muscarin. Ọ na-abawanye mkpụkọ nke uru ahụ dị nro nke eriri afọ na eriri anụ ahụ nke duodenum, ileum, na colon.

Ọrụ na ngwa ahụike:

Analgesia na Central Neervous System Effects: Arecoline hydrobromide na-egosipụta ihe analgesic ma nwee mmetụta na-eme ka ahụ dị jụụ na usoro nhụjuanya nke etiti.

Ahụ Ike Skin: Arecoline hydrobromide na-akwalite metabolism anụ ahụ ma gosipụta ikike ịgwọ ọnya anụ ahụ na ọrịa anụ ahụ ndị ọzọ.

Detoxification na Diuretic Effects: Arecoline hydrobromide na-ekpochapụ okpomọkụ, detoxifies, na-ewepụ dampness na ọzịza, ma nwee mmetụta diuretic.

Antibacterial na Mgbaze Nkume: Arecoline hydrobromide na-egosiputa Njirimara antibacterial na ikike igbari nkume.

Mgbochi Ọbara na Mgbasa Ọbara: Arecoline hydrobromide na-enyere aka mee ka arịa ọbara sie ike ma kwalite mgbasa ọbara.

Ngwa:

Mmeju nri ahụike: Enwere ike iji Arecoline dị ka ihe mgbakwunye na mgbakwunye nri ahụike na-ezubere ọrụ ahụike akọwapụtara, dị ka nkwalite ọgụgụ isi ma ọ bụ ahụike anụ ahụ.

Pharmaceuticals: Arecoline nwere ike ịnwe ngwa ngwa na ọgwụ, ọkachasị na ọgwụgwọ ọrịa uche ma ọ bụ dị ka ọgwụ antihelmintic.

Nkwadebe ịchọ mma: nkwalite metabolism akpụkpọ anụ nke Arecoline na ihe nwere ike ịgwọ ọnya na-eme ka ọ bụrụ onye na-akwado maka nkwadebe ịchọ mma, karịsịa ndị na-elekwasị anya ọnya anụ ahụ ma ọ bụ ọrịa ndị ọzọ metụtara akpụkpọ ahụ.

Arecoline, alkaloid na-arụsi ọrụ ike dị na nut areca, na-egosipụta mmetụta ọgwụgwọ dị iche iche ma nwee ngwa na usoro ahụ dị iche iche. A na-emezi usoro omume ya site na ndị na-anabata muscarin ma gosipụta mmetụta parasympathetic. Ọ bụ ezie na arecoline na-egosi nkwa n'ịgbasa ụfọdụ ọnọdụ ahụike, ọ dị mkpa ịtụle mmetụta ndị nwere ike ime nsí na ihe ndị na-akpata carcinogenic jikọtara ya na iji ya. Kpọtụrụ anyị ma ọ bụrụ na ọ dị mkpa.

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