Ọmụmụ ọmụmụ akaghi aka na-ebute nnukwu ihe egwu na ibu dịịrị ma ezinụlọ ma ọha mmadụ n'ozuzu ya. N'ihi ya, mgbochi na ọgwụgwọ ọmụmụ akaghi aka bụ ihe kacha mkpa. Tocolytics, dị ka atosiban, na-ekere òkè dị mkpa na igbu oge ime ime na ichekwa nwa ebu n'afọ. Atosiban, cyclic nonapeptide na analog oxytocin, na-eme dị ka onye na-emegide asọmpi nke ndị na-anabata oxytocin n'ime akpanwa, decidua, na akpụkpọ anụ nwa ebu n'afọ. Site n'igbochi mmechi nke akpanwa, atosiban apụtala dị ka ngwá ọrụ ụlọ ọgwụ bara uru n'ịgwọ ọmụmụ akaghi aka.
Atosiban, dị ka ngwakọta oxytocin na vasopressin V1A antagonist na-anabata ya, na-enye ụzọ pụrụ iche iji gbochie nkwụsị nke akpanwa. Myirịta dị n'etiti onye na-anabata oxytocin na onye na-anabata vasopressin V1A na-achọ ka mgbochi nke ụzọ abụọ ahụ na-anabata ya n'otu oge iji gbochie nkwụsị nke akpanwa nke ọma. N'adịghị ka tocolytics ndị ọzọ dị ka beta-agonists, calcium channel blockers, na prostaglandin synthase inhibitors, atosiban's dual receptor antagonism na-enye ohere maka mmachi nke ọma nke mgbochi uterine. Oxytocin, na mgbakwunye na nke na-akpali akpali contractions nke akpanwa, na-akpali mmepụta na ntọhapụ nke PGF2a, nke na-enye aka n'ihu na-eme ka uterine ezigbo muscle mkpirisi. Mmekọrịta dị elu nke Atosiban maka ndị na-anabata oxytocin na vasopressin V1A na-ejikọ aka na ndị nnabata ndị a, na-egbochi ụzọ omume nke oxytocin na vasopressin. Usoro a na-eduga n'ịbelata nkwụsị nke akpanwa.
Otu n'ime uru dị ịrịba ama nke atasiban bụ obere mmetụta ya. Ọ bụ ezie na a kọwawo tachycardia dị nro, njigide obi, isi ọwụwa, isi ọwụwa, ọgbụgbọ, na dyspnea, mmetụta ndị a n'ozuzu ha achọghị ọgwụgwọ pụrụ iche, ọ naghị adịkarịkwa akwụsị ọgwụ ahụ n'ihi mmetụta ndị dị na ya. Ọzọkwa, atosiban nwere obere ọkara ndụ plasma dị mkpirikpi, na-egbochi nchịkọta ya na mgbasa nke nwa ebu n'afọ ma na-ebelata ihe ize ndụ nke mmetụta ọjọọ na nwa ebu n'afọ. Nnwale nyocha egosila irè atosiban n'ịgbatị afọ ime n'ime ụmụ nwanyị nwere ihe karịrị izu 28 nke ime ime. N'ime multicenter, kpuru ìsì abụọ, ebe a na-achịkwa ebebo, ọgwụgwọ atosiban mere ka ime ogologo oge ruo ụbọchị asaa. Nnwale ụlọ ọgwụ atụnyere egosikwa na atosiban nwere mmetụta tocolytic yiri nke ahụ na ritodrine ebe a na-anabata ya nke ọma, ọkachasị n'ihe gbasara nsonaazụ obi nke nne. Nchọpụta ndị a na-akọwapụta ikike nke atasiban dị ka ihe na-arụ ọrụ nke ọma na nke na-anabata ya nke ọma.
Atosiban, dị ka onye na-emegide vasopressin/oxytocin receptor antagonist, na-arụ ọrụ dị mkpa n'igbochi ọmụmụ akaghi aka. Ikike ya igbochi mmechi nke akpanwa site na mgbochi abụọ nke nnabata na-eme ka ọ bụrụ ngwá ọrụ bara uru maka igbu oge ọrụ tupu oge eruo. Mmetụta dị ntakịrị, ọkara ndụ plasma dị mkpụmkpụ, yana oke mkpokọta na mgbasa nke nwa ebu n'afọ na-eme ka profaịlụ nchekwa ya dịkwuo mma. Na mgbakwunye, ikike atosiban nwere n'ịkwalite nsonaazụ afọ ime n'ime ndị ọrịa nwere ọdịda ntinye ugboro ugboro na IVF-ET na-egosipụta ike ya na ikike ya na ọgwụ ịmụ nwa. Nnyocha na-aga n'ihu na iji atasiban eme ihe n'ụlọ ọgwụ nwere ike inye aka nke ukwuu n'ibelata ibu nke ịmụ nwa akaghi aka n'ezinụlọ na ọha mmadụ.
