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Cisplatin ntụ ntụ Cisplatin ịdị ọcha 99% Cisplatin Pharmaceutical
Nkọwa zuru ezu
Cisplatin, nke aha ahia ya mara Platinol, bụ ọgwụ chemotherapy eji agwọ ụdị ọrịa cancer dị iche iche.
Ọdịdị: Cisplatin bụ ọcha na-acha ọcha crystalline ntụ ntụ na-adịchaghị mma na-esi ísì. Ọ na-adị ntakịrị soluble na mmiri ma na-agbaze na chloride ngwọta na ụfọdụ ihe mgbaze organic. A na-echekwa ogige dị ọcha n'ebe kpọrọ nkụ, ọchịchịrị n'okpuru nchịkwa. Mgbe a na-echekwa ya nke ọma, cisplatin na-edobe ike ya na ike ya. Ọ bụ Alfred Werner bụ onye Switzerland bụ onye Switzerland chemist bụ onye nwetara Nrite Nobel na Chemistry na 1913 maka ọrụ ya na nhazi nhazi.Cisplatin mere ya na 1844 emesia nyochara maka ihe nwere ike igbochi kansa ma chọpụta na ọ dị irè n'ịgwọ ọrịa ọjọọ dị iche iche.
Ọrụ na Ngwa: A na-ekewa Cisplatin dị ka ọgwụ chemotherapy dabeere na platinum, ọ bụkwa akụkụ nke ezinụlọ alkylating. Ọ na-arụ ọrụ anticancer ya site n'ịme njikọ covalent na DNA, na-eduga ná nkwụsị nke ọrụ cell na n'ikpeazụ na-akpata ọnwụ cell. , cisplatin na-ejikọta na ntọala purine na DNA, na-eme ka intrastrand na interstrand crosslinks. Ndị a crosslinks na-egbochi DNA replication na transcription, na-eduga na mgbochi nke cell mgbasa na ntinye nke apoptosis na mkpụrụ ndụ cancer.Cisplatin na-ejikarị na-agwọ ọrịa dị iche iche. ụdị ọrịa kansa, gụnyere testicular, ovarian, eriri afo, isi na olu, akpa ume, na ọrịa kansa cervical.
Ọ na-abụkarị akụkụ nke usoro ọgwụgwọ chemotherapy jikọtara ọnụ ma na-enye ya n'ime ụlọ ọgwụ n'okpuru nlekọta nke ndị ọkachamara ahụike. Nchikota cisplatin na ndị ọzọ na-ahụ maka chemotherapeutic, dị ka etoposide, bleomycin, na fluorouracil, egosipụtawo mmetụta synergistic na ọgwụgwọ ụfọdụ. Malignancies.Na mgbakwunye na ọrụ ya bụ isi na ọrịa ụbụrụ siri ike, a na-ejikwa cisplatin na-agwọ ọrịa germ cell etuto ahụ, ma dịka otu onye na-ejikọta ya na ọgwụ ndị ọzọ chemotherapy. karịsịa mgbe ejiri ya na ihe ndị ọzọ dabeere na platinum dị ka etoposide na bleomycin. Ọzọkwa, a mụọla cisplatin maka ntinye ya na ụdị ọrịa cancer ndị ọzọ, gụnyere esophageal, gastric, na ọrịa cancer pancreatic.
Nnyocha na-aga n'ihu na-enyocha ịdị irè ya na nchikota na usoro ọgwụgwọ ezubere iche maka ọgwụgwọ na immunotherapies iji kwalite nsonaazụ ọgwụgwọ ma belata mmepe nke nguzogide. ahụ iji gbuo mkpụrụ ndụ kansa ma ọ bụ mee ka ha nwekwuo mmetụta maka ọgwụgwọ ndị ọzọ. N'okwu a, a na-eji cisplatin jikọtara ya na okpomọkụ iji kwalite mmetụta cytotoxic ya n'ime microenvironment tumor.
Na nchịkọta, cisplatin bụ ọgwụ chemotherapy nke sitere na platinum sịntetik nke na-egosipụta mmetụta anticancer site n'ịmepụta DNA crosslinks na ịkpata ọnwụ cell na mkpụrụ ndụ kansa. ọrịa cancer cervical, na nyocha na-aga n'ihu na-enyocha ike ya na ọrịa ọjọọ ndị ọzọ. Na mgbakwunye, cisplatin nwere ngwa ngwa na ọgwụgwọ hyperthermia ma na-aga n'ihu na-abụ akụkụ dị mkpa nke usoro ọgwụgwọ chemotherapy jikọtara ọnụ.
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