0102030405
Tirzepatide Dual GLP-1 na GIP Nnabata Agonist maka njikwa ibu na njikwa glycemic.
Nkọwa zuru ezu
Tirzepatide bụ ọgwụ ọhụrụ a na-eji maka njikwa ibu ogologo oge na ndị ọrịa nwere oke oke ibu ma ọ bụ nsogbu metụtara ibu. Ọ bụ agonist na-adabere na glucose nke glucagon polypeptide (GIP) na ndị na-anabata glucagon-dị ka peptide-1 (GLP-1). FDA kwadoro na 2022, tirzepatide na-ejikọta mmetụta nke proinsulin abụọ na-abanye n'ime otu molecule, na-eme ka mmepụta insulin dịkwuo elu ma na-ebelata ọkwa glucagon. Edemede a na-enyocha usoro omume, nrụpụta ụlọ ọgwụ, yana profaịlụ nchekwa nke tirzepatide dị ka ọgwụgwọ mgbakwunye maka mbelata ibu yana njikwa glycemic ka mma na ndị ọrịa nwere ụdị ọrịa shuga 2.
I. Ịghọta Tirzepatide:
A. Glucose agonist nke GIP na GLP-1 ndị na-anabata ya
B. Usoro nke ime ihe: ịkwalite ọkwa nke mbụ na nke abụọ nke insulin, na-ebelata ọkwa glucagon
II. Ojiji ụlọ ọgwụ yana nnabata FDA:
A. Ngosipụta: Nlekọta ịdị arọ ogologo oge na ndị ọrịa nwere oke oke ibu ma ọ bụ nsogbu metụtara ibu
B. Usoro ọgwụgwọ maka imeziwanye njikwa glycemic na ndị okenye nwere ụdị ọrịa shuga 2
C. FDA kwadoro na ire ahịa site n'aka Eli Lilly na 2022
III. Ịdị irè na njikwa ibu:
A. Ntụnyere arụmọrụ:
Pasent nke ọnwụ dị arọ: obere dose (5mg), ọkara-dose (10mg), na elu-dose (15mg) otu
Nkezi pasentị ibu ibu dị n'otu usoro onunu ogwu
Tụnyere otu placebo
Pasent nke isiokwu na-enweta mbelata ibu karịa 20%
B. Profaịlụ nchekwa: Ugboro nke mmeghachi omume ọjọọ tụnyere placebo otu
C. Tụnyere ọgwụ ndị ọzọ na-ebelata ibu arọ:
Orlistat (over-the-counter): Ọdịiche dị na pasentị ọnwụ arọ
IV. Usoro njikwa glycemic na mbelata ibu:
A. Nrụ ọrụ nke GLP-1 na ndị na-anabata GIP
B. Mbelata nke agụụ na mbelata nke oriri
Tirzepatide, dị ka GLP-1 dual na GIP agonist receptor, na-enye njikwa ịdị arọ dị irè yana njikwa glycemic dị mma na ndị ọrịa nwere oke ibu ma ọ bụ nsogbu metụtara ibu, yana ndị nwere ụdị ọrịa shuga 2. Usoro ọrụ ya dabere na glucose na-eme ka mmepụta insulin dịkwuo elu ma na-ebelata ọkwa glucagon. Site na pasentị dị arọ dị arọ na profaịlụ nchekwa dị mma, tirzepatide pụtara dị ka ọgwụ siri ike maka njikwa ibu ogologo oge. Nnyocha ndị ọzọ na ọmụmụ ụlọ ọgwụ ga-anọgide na-enyocha uru na ngwa nke ọgwụ a na-ekwe nkwa.
Iji nye ahụmịhe azụmaahịa ka mma, anyị nwere ike hazie ngwaahịa capsule na mmiri mmiri, dịka ihe ndị ị chọrọ.
Anyị nwere ike hazie usoro onunu ogwu: 500mg/capsule, 550mg/capsule, 600mg/capsule.
Anyị nwere ike hazie nkwakọ ngwaahịa: 60 okpu / karama, 90 okpu / karama, 120 okpu / karama.
Anyị nwere ike hazie shells capsule na agba: osisi capsule shells, gelatin capsule shells.
Nkọwapụta
