0102030405
Vincristine sulfate ntụ ntụ Vincristine ịdị ọcha Vincristine CAS 57-22-7
Nkọwa zuru ezu
Vincristine bụ ihe na-acha ọcha na-acha ọcha crystalline powder.It bụ fọrọ nke nta insoluble na mmiri,ma ọ dissolves na ụfọdụ organic solvents.The dị ọcha compound bụ odorless na a na-echekwara na a akọrọ, ọchịchịrị ebe n'okpuru achịkwa okpomọkụ ọnọdụ ịnọgide na-enwe nkwụsi ike. It is a naturally occurring alkaloid derived from the Madagascar periwinkle plant(Catharanthus roseus) .Its chemical structure resembles that of vinblastine,other vinca alkaloid.Vincristine na ọtụtụ-eji na ọgwụgwọ nke dị iche iche nke ọrịa cancer, gụnyere leukemia,lymphoma,na siri ike etuto ahụ. .
Vincristine bụ ihe mgbochi microtubule nke na-akpaghasị nguzobe nke microtubules, nke bụ akụkụ dị mkpa nke cytoskeleton cell. Site na ijikọ na tubulin, ọ na-egbochi mgbakọ nke microtubules, na-eduga na njide mitotic na ọnwụ cell na-ekesa sel na-arụsi ọrụ ike. vincristine karịsịa dị irè megide ngwa ngwa nkewa mkpụrụ ndụ cancer. Ngwa ahụike nke vincristine gụnyere ọgwụgwọ ọrịa dị iche iche dị ka nnukwu lymphoblastic leukemia(ALL), lymphomas Hodgkin na ndị na-abụghị Hodgkin, ọrịa ụmụaka na okenye siri ike, neuroblastoma, na rhabdomyosarcoma.Vinstine na-ejikarị eme ihe.Vincristine. yana ndị ọrụ chemotherapeutic ndị ọzọ dị ka akụkụ nke usoro ọgwụgwọ ọtụtụ ọgwụ, nke a na-akpọkọta ọnụ dị ka ngwakọta chemotherapy.
Na mgbakwunye na ojiji ya bụ isi na ọgwụgwọ ọrịa kansa, vincristine egosipụtakwala ịdị irè na njikwa nke ụfọdụ ọnọdụ ndị na-abụghị nke oncological. A na-eji ya na ọgwụgwọ nke idiopathic thrombocytopenic purpura (ITP), ọrịa autoimmune nke ejiri obere platelet mara. , vincristine egosila ikike na njikwa nke ọnọdụ akwara dị iche iche, gụnyere ọrịa na-adịghị ala ala demyelinating polyneuropathy (CIDP) na ọrịa autoimmune neuropsychiatric pediatric jikọtara ya na ọrịa streptococcal (PANDAS).
Ọzọkwa, vincristine's anti-angiogenic Properties emewo ka nchọpụta nke nwere ike iji na ọgwụgwọ nke ọrịa dị iche iche proliferative, gụnyere ọrịa shuga retinopathy na afọ metụtara macular degeneration. Otú ọ dị, vincristine bụ isi mara maka ọrụ ya na ọgwụgwọ ọrịa cancer, na ojiji ya Na nchịkọta, vincristine, nke sitere na osisi periwinkle Madagascar, bụ ihe bara uru na-egbochi ọrịa cancer nke na-akpaghasị nhazi microtubule ma na-ebute ọnwụ cell na-ekewa mkpụrụ ndụ. ngwa ngwa ụlọ ọgwụ dịgasị iche iche gụnyere ọgwụgwọ ọrịa leukemia, lymphoma, etuto siri ike, na ụfọdụ ọnọdụ ndị na-abụghị nke oncological. Ọ bụ ezie na a na-ejikarị ya eme ihe na ọgwụgwọ ọrịa cancer, nchọpụta na-aga n'ihu na-aga n'ihu na-achọpụta ike ya na ọnọdụ ahụike dị iche iche.
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