Arecoline hydrobromide Therapeutic Potential in Central nervous system

Mtengo Wolozera: USD15-20/g

Dzina lazogulitsa Arecoline
CAS No. 300-08-3
MF C8H14BrNO2
MW 236.109
Malingaliro a kampani EINECS 206-087-3
Acidity coefficient (pka) 6.84 (pa 25 ℃)
Malo osungunuka 171-175 ° C

Lumikizanani nafe

tsatanetsatane wazinthu

Kufotokozera Mwatsatanetsatane

Arecoline, alkaloid yogwira ntchito kwambiri yopezeka mu areca nut, yadziwika chifukwa cha kuthekera kwake kochizira matenda amisala komanso kuchepetsa matenda am'mimba. Nkhaniyi ikufuna kupereka chidule cha ndondomeko ya machitidwe a arecoline m'machitidwe osiyanasiyana a thupi, kuphatikizapo m'kamwa, m'katikati mwa mitsempha, dongosolo la mtima, ndi kugaya chakudya. Kuphatikiza apo, magwiridwe antchito azaumoyo ndi zotsatira zoyipa za arecoline zidzawunikidwa. Pomaliza, kugwiritsa ntchito arecoline muzakudya zopatsa thanzi, mankhwala, ndi zodzoladzola zidzakambidwa.

Arecoline, nicotinic acid-based mild parasympathomimetic stimulant alkaloid, makamaka amakhala ngati agonist pang'ono wa muscarinic acetylcholine receptors. Imawonetsa zotsatira za parasympathetic m'malo movutitsa nicotinic acetylcholine receptors ngati chikonga. Arecoline imalepheretsanso AMPK (adenosine monophosphate-activated protein kinase) kupyolera mu mbadwo wa mitundu yogwira ntchito ya okosijeni (ROS) mu mitundu yosiyanasiyana ya maselo.

Zotsatira Pamachitidwe Osiyanasiyana a Thupi:

Nervous System: Arecoline imalimbikitsa chisangalalo, imapangitsa kuphunzira ndi kukumbukira, imachepetsa zizindikiro za kuvutika maganizo ndi schizophrenia. Ikhozanso kusinthira kukumbukira kukumbukira komwe kumabwera chifukwa cha scopolamine.

Cardiovascular System: Arecoline imakhala ngati vasodilator, imawonjezera plasma nitric oxide, eNos, ndi mRNA mawu, ndipo imawonetsa anti-thrombosis ndi anti-atherogenic zotsatira. Imachepetsanso IL-8 ndi zinthu zina.

Endocrine System: Arecoline imalimbikitsa maselo a Leydig, zomwe zimapangitsa kuti ma testosterone achuluke. Imayendetsa axis ya hypothalamic-pituitary-adrenal (HPA), kulimbikitsa kutulutsidwa kwa mahomoni a corticotropin-releasing (CRH). Kuphatikiza apo, zimathandizira kupewa kukanika kwa maselo a pancreatic beta chifukwa cha kudya kwambiri fructose.

Digestive System: Arecoline imayambitsa kugaya chakudya kudzera mu kuyambitsa kwa muscarinic receptors. Imawonjezera kugunda kwa m'mimba yosalala minofu ndi minofu ya duodenum, ileum, ndi colon.

Ntchito Zaumoyo ndi Ntchito:

Analgesia ndi Central Nervous System Effects: Arecoline hydrobromide imasonyeza mphamvu zowonongeka ndipo imakhala ndi mphamvu yokhazikika pakatikati pa mitsempha.

Thanzi Lapakhungu: Arecoline hydrobromide imalimbikitsa kagayidwe ka khungu ndikuwonetsa kuthekera kochiza zilonda zapakhungu ndi matenda ena apakhungu.

Kuchotsa poizoni ndi Zotsatira za Diuretic: Arecoline hydrobromide imachotsa kutentha, imatulutsa poizoni, imachotsa chinyontho ndi kutupa, ndipo imakhala ndi diuretic katundu.

Miyala ya Antibacterial ndi Kusungunuka: Arecoline hydrobromide imawonetsa antibacterial katundu komanso kuthekera kosungunula miyala.

Kulimbitsa Mitsempha ya Magazi ndi Kuzungulira kwa Magazi: Arecoline hydrobromide imathandiza kulimbikitsa mitsempha ya magazi ndikulimbikitsa kuyenda kwa magazi.

Mapulogalamu:

Zowonjezera Zakudya Zaumoyo: Arecoline ingagwiritsidwe ntchito ngati chophatikizira muzakudya zopatsa thanzi zomwe zimayang'ana ntchito zinazaumoyo, monga kukulitsa chidziwitso kapena thanzi la khungu.

Mankhwala: Arecoline ikhoza kukhala ndi ntchito zomwe zingagwiritsidwe ntchito m'zamankhwala, makamaka pochiza matenda amisala kapena ngati mankhwala a antihelmintic.

Kukonzekera Zodzoladzola: Kupititsa patsogolo kagayidwe ka khungu la Arecoline ndi kuchiritsa mabala kumapangitsa kukhala woyenera kukonzekera zodzoladzola, makamaka zomwe zimayang'ana zilonda zapakhungu kapena matenda ena okhudzana ndi khungu.

Arecoline, alkaloid yogwira yomwe imapezeka mu mtedza wa areca, imawonetsa machiritso osiyanasiyana ndipo imagwiritsidwa ntchito m'machitidwe osiyanasiyana amthupi. Njira zake zogwirira ntchito zimalumikizidwa makamaka kudzera muzolandilira muscarinic ndikuwonetsa zotsatira za parasympathetic. Ngakhale kuti arecoline ikuwonetsa kulonjeza pothana ndi zovuta zina zaumoyo, ndikofunikira kuganizira zomwe zingachitike poizoni komanso zinthu za carcinogenic zomwe zimagwirizana ndi kugwiritsidwa ntchito kwake. Lumikizanani nafe ngati mukufunikira.

Kufotokozera