Kubadwa msanga kumabweretsa zowopsa komanso zolemetsa kwa mabanja ndi anthu onse. Chifukwa chake, kupewa ndi kuchiza kubadwa msanga ndikofunikira kwambiri. Ma tocolytics, monga atosiban, amagwira ntchito yofunika kwambiri pakuchedwetsa kubereka mwana asanakwane komanso kuteteza mwana wosabadwayo. Atosiban, cyclic nonapeptide ndi analogue ya oxytocin, imakhala ngati mpikisano wotsutsana ndi oxytocin receptors mu chiberekero, decidua, ndi nembanemba ya fetal. Poletsa kutsekeka kwa uterine, atosiban yatulukira ngati chida chachipatala chofunikira pochiza kubadwa msanga.
Atosiban, monga oxytocin ophatikizana ndi vasopressin V1A receptor antagonist, amapereka njira yapadera yoletsa kutsekeka kwa uterine. Kufanana kwapangidwe pakati pa oxytocin receptor ndi vasopressin V1A receptor kumafunikira kutsekeka kwakanthawi kofanana kwa njira zonse zolandirira kuti aletse kutsekeka kwa chiberekero. Mosiyana ndi ma tocolytics ena monga beta-agonists, calcium channel blockers, ndi prostaglandin synthase inhibitors, atosiban's dual receptor antagonism amalola kuletsa kogwira mtima kwa kutsekeka kwa uterine. Oxytocin, kuphatikizapo kulimbikitsa chiberekero, imalimbikitsanso kupanga ndi kutulutsidwa kwa PGF2α, zomwe zimapangitsa kuti uterine ikhale yosalala. Kugwirizana kwakukulu kwa Atosiban kwa oxytocin ndi vasopressin V1A zolandilira zimamangiriza mopikisana ndi zolandilira izi, ndikutsekereza njira za oxytocin ndi vasopressin. Njira imeneyi imapangitsa kuti chiberekero chichepetse.
Ubwino umodzi wofunikira wa atosiban ndi zotsatira zake zochepa. Ngakhale kuti tachycardia wochepa, chifuwa cholimba, chizungulire, kupweteka mutu, nseru, ndi dyspnea zanenedwa, zotsatirazi nthawi zambiri sizifuna chithandizo chapadera, ndipo mankhwalawa sasiya kawirikawiri chifukwa cha zotsatira zake. Komanso, atosiban amakhala ndi theka la moyo waufupi wa plasma, zomwe zimalepheretsa kudzikundikira kwake m'magazi a mwana wosabadwayo komanso kuchepetsa chiopsezo cha mwana wosabadwayo. M'mayesero apakati, akhungu awiri, oyendetsedwa ndi placebo, chithandizo cha atosiban chinapangitsa kuti mimba ikhale yotalikirapo mpaka masiku 7. Mayesero ofananiza azachipatala awonetsanso kuti atosiban ali ndi zochita zofananira za tocolytic ku ritodrine pomwe akulekerera bwino, makamaka potengera zotsatira za mtima wamayi. Zotsatirazi zikuwonetsa kuthekera kwa atosiban ngati wothandizira komanso wololera bwino wa tocolytic.
Atosiban, monga mpikisano wa vasopressin/oxytocin receptor antagonist, amagwira ntchito yofunika kwambiri popewa kubadwa msanga. Kuthekera kwake kuletsa kutsekeka kwa uterine kudzera mukutsutsana ndi ma receptor awiri kumapangitsa kukhala chida chofunikira kwambiri chochedwetsa kubereka msanga. Zotsatira zochepa, theka la moyo waufupi wa plasma, komanso kudzikundikira pang'ono mu kufalikira kwa fetal kumawonjezera chitetezo chake. Kuphatikiza apo, kuthekera kwa atosiban pakuwongolera zotulukapo za mimba mwa odwala omwe amalephera kubzalidwa mobwerezabwereza akudutsa IVF-ET akuwonetsa kusinthasintha kwake komanso kuthekera kwamankhwala obereka. Kafukufuku wopitilira ndi kugwiritsa ntchito kwachipatala kwa atosiban kungathandize kwambiri kuchepetsa kulemedwa kwa kubadwa msanga kwa mabanja ndi anthu.
