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CARBETOCIN Postpartum Hemorrhage powder
Kufotokozera Mwatsatanetsatane
Chiyambi:
Carbetocin, analogi ya oxytocin yopangidwa kwa nthawi yayitali, imakhala ndi zinthu zofanana ndi oxytocin yochitika mwachilengedwe. Imakhala ngati agonist, yomangiriza ku uterine yosalala minofu yolandirira ndikupangitsa kuti chiberekero chikhale chokhazikika. Carbetocin imagwira ntchito makamaka m'chiberekero chapakati komanso chongobadwa kumene, chifukwa cholandilira cha oxytocin chimakhala chokwera kwambiri panthawiyi. M'nkhani ino, tiwona momwe carbetocin imagwirira ntchito komanso momwe imagwiritsidwira ntchito poletsa kutuluka kwa magazi pambuyo pobereka komanso kupewa kutsekeka kwa chiberekero pambuyo pa opaleshoni.
Ulamuliro wa Kutuluka kwa Kutuluka kwa M'mimba:
Carbetocin ndi mankhwala amtengo wapatali omwe amagwiritsidwa ntchito pochiza kutaya magazi pambuyo pobereka, komwe kumatanthauza kutaya magazi kwambiri pambuyo pobereka. Poyambitsa kutsekeka kwa chiberekero, carbetocin imathandizira kubwezeretsa kamvekedwe ka chiberekero, kuchepetsa chiopsezo chotaya magazi kwambiri. Mphamvu yake yagona pakutha kuchulukitsa pafupipafupi komanso kupsinjika kwa kutsekeka kwa uterine, kuteteza kapena kuchepetsa kutulutsa kwamagazi pambuyo pobereka.
Carbetocin nthawi zambiri amaperekedwa pambuyo popanga opaleshoni ya epidural kapena msana panthawi ya opaleshoni kuti ateteze kutsekeka kwa uterine ndikutuluka kwa magazi pambuyo pobereka. Mchitidwewu umatsimikizira kuti minofu ya chiberekero imakhalabe yogwirizana, kuchepetsa mwayi wotuluka magazi kwambiri. Komabe, kugwiritsa ntchito carbetocin m'magawo opangira opaleshoni mwadzidzidzi, magawo opangira opaleshoni akale, komanso pansi pa mitundu ina ya anesthesia kapena pamaso pazikhalidwe zachipatala sikunaphunzire mozama. Choncho, kusamala kuyenera kuchitidwa poganizira za kayendetsedwe ka carbetocin muzochitika izi.
Kachitidwe Kachitidwe:
Carbetocin amagwira ntchito ngati mankhwala oxytocic, antihemorrhagic, ndi uterotonic, makamaka akuyang'ana dongosolo lamanjenje. Imakhala ngati agonist pa zotumphukira oxytocin zolandilira, makamaka mu myometrium (chiberekero minofu). Ma receptor a oxytocin awa ndi G mapuloteni ophatikizidwa, ndipo kuyambitsa kwawo kumaphatikizapo amithenga achiwiri ndi kupanga ma phosphates anositol. Carbetocin amatsanzira kachitidwe kameneka, kumangiriza mosasankha pa extracellular N-terminus ndi malupu E2 ndi E3 a oxytocin receptor. Ngakhale carbetocin ndi oxytocin ali ndi kuyanjana kofanana kwa zolandilira, mphamvu yachilengedwe ya carbetocin imakhala pafupifupi 50% ya oxytocin wamkati kapena wakunja. Makamaka, carbetocin imakhala ndi mphamvu yokhalitsa kuposa oxytocin, yomwe imafuna mlingo umodzi wokha. Imalepheretsanso kutulutsa kwa endogenous oxytocin, kusokoneza mayendedwe a chiberekero ndi hypothalamus ndikuchepetsa kutulutsa kwapakati ndi zotumphukira za oxytocin. Carbetocin ikhoza kuonedwa ngati agonist wokondera wa oxytocin receptor.
Pa mimba, kaphatikizidwe wa oxytocin zolandilira mu chiberekero kwambiri, kufika pachimake pa nthawi yobereka ndi yobereka. Chifukwa chake, makonzedwe a carbetocin kapena ma analogi ena a oxytocin pa nthawi ya kubadwa kapena atangobadwa kumawonjezera zotsatira za uterotonic ndi contractile. Komabe, carbetocin ilibe mphamvu pa chiberekero chopanda mimba chokhala ndi mawu otsika a oxytocin receptor. Kuphatikiza apo, carbetocin imathandizira kuti magazi azichulukira, kumachepetsanso chiopsezo chotaya magazi pambuyo pobereka.
Kusamala ndi Zolepheretsa:
Ndikofunika kuzindikira kuti carbetocin sayenera kugwiritsidwa ntchito popititsa patsogolo ntchito kapena kukulitsa, chifukwa angayambitse matenda a mtima kapena kupuma mwa amayi ndi khanda.
Pomaliza:
Carbetocin, wopangidwa ndi oxytocin analogi, amapereka njira yothandiza kwambiri yothanirana ndi kukha magazi kwanthawi yobereka komanso kupewa kutaya magazi kwambiri pambuyo pa opaleshoni. Mwa kutsanzira machitidwe a oxytocin mwachibadwa, carbetocin imapangitsa kuti chiberekero chitseke ndipo chimalimbikitsa kamvekedwe ka chiberekero. Komabe, kugwiritsidwa ntchito kwake kuyenera kuganiziridwa mosamala pazochitika zinazake, ndipo akatswiri azaumoyo ayenera kusamala popereka carbetocin.
Kumbukirani kutilumikizana nafe pamtengo wa Carbetocin Factory mwachindunji.
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