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Memantine HCl 99% Purity amachiza matenda a Alzheimer's Factory Supply
Kufotokozera Mwatsatanetsatane
Memantine hydrochloride, yopangidwa ndi Merz ku Germany, ndi mankhwala omwe poyamba adapangidwa kuti azichiza matenda a dementia. Imakhala ngati N-methyl-D-aspartate (NMDA) receptor antagonist yosagwirizana ndi mpikisano, kutsekereza zolandilira za NMDA ndikuchepetsa kuthamangitsidwa kwa glutamate. Njirayi ikufuna kupititsa patsogolo chidziwitso, kuteteza apoptosis, komanso kukumbukira. Pethidine hydrochloride inavomerezedwa ndi European Committee for Patented Medicinal Products (CPMP) kuti athe kuchiza matenda a Alzheimer's apakati kapena aakulu mu 2002. Maphunziro owonjezera awonetsanso mphamvu zake kwa odwala omwe ali ndi matenda a Alzheimer's wochepa mpaka ochepa.
Memantine hydrochloride, chogwiritsidwa ntchito mu pethidine hydrochloride, ndi odziyimira pawokha, osachita mpikisano NMDA receptor antagonist. Ngakhale kuti ntchito yake yaikulu ndi chithandizo cha matenda a Alzheimer's, yakhala ikuphunziridwa mozama ndikugwiritsidwa ntchito pazovuta zina zapakati zamanjenje monga khunyu, migraines, ndi matenda a maganizo kuphatikizapo bipolar disorder ndi schizophrenia. Dementia ikadali yofunika kwambiri pakugwiritsa ntchito kwa memantine, ndipo yawonetsa milingo yosiyanasiyana yaubwino mu matenda a Alzheimer's, vascular dementia, ndi dementia ndi matupi a Lewy. Sizimangowonjezera kugwira ntchito kwachidziwitso komanso kuwongolera zizindikiro zamakhalidwe ndi malingaliro a dementia (BPSD), monga kuyerekezera zinthu m'maganizo, kunyenga, kukwiya, nkhanza, komanso kukwiya.
Kuwonjezera pa zotsatira zake pa matenda a dementia, memantine yafufuzidwa chifukwa cha zotsatira zake pa matenda ena a ubongo. Odwala khunyu nthawi zambiri amakhala ndi vuto la kuzindikira, ndipo memantine yawonetsa kuthekera kochepetsa zoperewerazi. Komanso, matenda a Alzheimer's ndi omwe amachititsa kuti munthu agwidwe, ndipo anthu omwe ali ndi matendawa ali pachiopsezo chachikulu chokhala ndi khunyu poyerekeza ndi omwe alibe Alzheimer's. Mwa kuletsa neuroexcitotoxicity yolumikizidwa ndi NMDA receptor hyperactivation, memantine akhoza kukhala ndi zotsatira za antiepileptic.
Kuphatikiza apo, memantine adaphunziridwa pankhani yamankhwala amtundu uliwonse waubongo (WBRT), kuvulala koopsa muubongo (TBI), ndi sitiroko. WBRT ingayambitse kuwonongeka kwa chidziwitso, ndipo memantine yasonyezedwa kuti imachedwetsa kuyamba kwake ndi kupititsa patsogolo kugwira ntchito kwa chidziwitso. Makhalidwe apadera a pharmacological a memantine apangitsa kuti ayambe kufufuza m'magulu osiyanasiyana a ubongo.
Kafukufuku waposachedwa wapereka lingaliro la kugwiritsa ntchito memantine pochepetsa zotsatira za neurotoxic za COVID-19 ndikuletsa kubwereza kwa ma virus, kuwonetsa kufunikira kwake kwachipatala.
Memantine hydrochloride, makamaka chogwiritsira ntchito memantine hydrochloride, yasonyeza kuti ndi yothandiza pochiza matenda a dementia, makamaka matenda a Alzheimer's. Njira yake yapadera ngati NMDA receptor antagonist imalola kusintha kwa chidziwitso ndi kasamalidwe ka zizindikiro zamakhalidwe ndi zamaganizo zomwe zimagwirizanitsidwa ndi dementia. Kuphatikiza apo, memantine amawonetsa lonjezano muzovuta zina zamanjenje monga khunyu, mutu waching'alang'ala, ndi kuwonongeka kwa chidziwitso cha post-radiation. Kafukufuku wopitilira akupitilizabe kufufuza za phindu lachipatala la memantine m'mikhalidwe yosiyanasiyana yaubongo.
Kumbukirani kulumikizana nafe kuti mupeze kalozera wathanzi.
Kumbukirani kulumikizana nafe kuti mupeze kalozera wathanzi.
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