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Zogulitsa Magulu
Zamgululi
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Rosuvastatin antilipidemic wothandizira Rosuvastatin amathandizira dyslipidemia
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Rosuvastatin antilipidemic wothandizira Rosuvastatin amathandizira dyslipidemia
Rosuvastatin antilipidemic wothandizira Rosuvastatin amathandizira dyslipidemia

Rosuvastatin antilipidemic wothandizira Rosuvastatin amathandizira dyslipidemia

Mtengo wolozera: USD 5-10/g

  • Dzina lazogulitsa Rosuvastatin
  • CAS No. 287714-41-4
  • MF Chithunzi cha C22H28FN3O6S
  • MW 481.54
  • Malingaliro a kampani EINECS 689-191-5
  • Kuchulukana 1.368±0.06 g/cm3(Zonenedweratu)
  • Malo osungunuka 161.9 °C
Lumikizanani nafe
tsatanetsatane wazinthu

Kufotokozera Mwatsatanetsatane

Rosuvastatin ndi mankhwala omwe amagwiritsidwa ntchito pochiza hypercholesterolemia ndi zovuta zina. Mankhwalawa, omwe amadziwika kuti ma statins, amagwiritsidwa ntchito limodzi ndi masewera olimbitsa thupi, kuwongolera zakudya, komanso kuchepa thupi kuti achepetse cholesterol komanso kupewa matenda amtima. Nkhaniyi iwunika momwe rosuvastatin imagwirira ntchito komanso momwe amagwiritsidwira ntchito kuchipatala, komanso zotsatira zake pazovuta za lipid komanso thanzi lamtima wonse.

Rosuvastatin, yemwe amadziwika kuti ndi antilipidemic wothandizira komanso membala wa gulu la statins, amagwiritsidwa ntchito makamaka pochiza dyslipidemia, kuphatikiza cholesterol yayikulu. Zimagwira ntchito poletsa puloteni yomwe imakhudzidwa ndi kupanga mafuta a kolesterolini m'thupi, zomwe zimapangitsa kuti mafuta a kolesterolini awonongeke ndi triglycerides, pamene nthawi yomweyo akuwonjezera kuchuluka kwa cholesterol yochuluka kwambiri (HDL), yomwe nthawi zambiri imatchedwa cholesterol "yabwino". Rosuvastatin ndiyothandiza kwambiri ikaphatikizidwa ndi zakudya zopatsa thanzi komanso masewera olimbitsa thupi. Kuphatikiza apo, amagwiritsidwa ntchito pochiza anthu omwe ali ndi matenda ena obadwa nawo a cholesterol. Kugwiritsiridwa ntchito kwachipatala kwa rosuvastatin kumaphatikizapo kuchiza hypercholesterolemia yoyambirira, hypercholesterolemia yabanja, ndi matenda a lipid omwe amayamba chifukwa cha zinthu zina.


17141224458349bv

Rosuvastatin imalepheretsa enzyme hydroxymethylglutaryl-CoA reductase m'chiwindi, yomwe imachepetsa kaphatikizidwe ka cholesterol ndikuchepetsa kuchuluka kwa cholesterol m'magazi ndi triglyceride. Kuphatikiza apo, rosuvastatin imawonjezera kutengeka kwa chiwindi ndikuwonongeka kwa cholesterol yotsika kachulukidwe lipoprotein (LDL-C), komanso imakweza kuchuluka kwa cholesterol yapamwamba kwambiri ya lipoprotein (HDL-C). Kuphatikiza pa kutsitsa kwa lipid-kuchepetsa, rosuvastatin yawonetsedwa kuti ili ndi anti-atherosclerotic, anti-inflammatory, antioxidant, plaque stabilizing, komanso endothelial function properties.

Rosuvastatin imapangidwa kudzera mu nayonso mphamvu ya Aspergillus terreus kapena kudzera mu kaphatikizidwe ka mankhwala. Akalowetsedwa, amapangidwa kwambiri m'chiwindi ndikusinthidwa kukhala ma metabolites osiyanasiyana, kuphatikiza ma metabolites omwe amalepheretsa HMG-CoA reductase. Mankhwalawa ndi ma metabolites ake amachotsedwa makamaka mu ndowe, ndipo pang'ono amachotsedwa mumkodzo.


Poletsa mpikisano woletsa HMG-CoA reductase, kuchuluka kwa enzyme mu kaphatikizidwe ka cholesterol, lovastatin imachepetsa kupanga kwapakatikati kwa cholesterol ndikuwonjezera kuwonetsera kwa LDL receptors m'maselo a chiwindi. Izi zimabweretsa kuwonjezeka kwa chiwongolero cha LDL cholesterol. Lovastatin imathandizanso kuchepetsa kuchuluka kwa seramu triglyceride ndikuwonjezera kuchuluka kwa cholesterol ya HDL, zomwe zimathandizira kupewa komanso kuchiza matenda a atherosclerosis ndi matenda amtima.

mankhwala1 (3)hq6katundu1 (4)mnpkatundu1 (6)zef


Rosuvastatin ndi mankhwala ofunikira pochiza hypercholesterolemia ndi zovuta zina. Rosuvastatin imagwira ntchito poletsa kupanga mafuta m'thupi ndikuwongolera kuchuluka kwa mafuta m'thupi limodzi ndi kusintha kwa moyo. Kumbali ina, imalepheretsa kaphatikizidwe ka cholesterol ndikuwonjezera kutengeka kwachiwindi ndikuwonongeka kwa LDL cholesterol, zomwe zimapangitsa kuchepa kwa cholesterol ndi triglycerides. Zawonetsa kuthandizira pakuwongolera zovuta za lipid komanso thanzi la mtima wonse. Ndikofunika kuti tikambirane nafe kuti tipeze chiwongolero cha akatswiri a zaumoyo kuti adziwe kagwiritsidwe ntchito koyenera ndi mlingo wa mankhwalawa malinga ndi zosowa za munthu payekha komanso mbiri yachipatala.

Kufotokozera

17141240096082va