0102030405
Tirzepatide Dual GLP-1 ndi GIP Receptor Agonist for Weight Management and Glycemic Control
Kufotokozera Mwatsatanetsatane
Tirzepatide ndi mankhwala omwe amagwiritsidwa ntchito powongolera kulemera kwanthawi yayitali kwa odwala onenepa kwambiri omwe ali ndi kunenepa kwambiri kwa akulu kapena zovuta zokhudzana ndi kulemera. Ndi agonist wodalira shuga wa glucagon polypeptide (GIP) ndi glucagon-ngati peptide-1 (GLP-1) receptors. Movomerezedwa ndi FDA mu 2022, tirzepatide imaphatikiza zotsatira za ma proinsulin awiri a enteric kukhala molekyulu imodzi, kukulitsa katulutsidwe ka insulin ndikuchepetsa kuchuluka kwa glucagon. Nkhaniyi ikuwonetsa momwe zimagwirira ntchito, mphamvu zachipatala, komanso mbiri yachitetezo cha tirzepatide ngati njira yothandizira kuchepetsa thupi komanso kuwongolera glycemic control mwa odwala omwe ali ndi matenda amtundu wa 2.
I. Kumvetsetsa Tirzepatide:
A. Wothandizira Glucose wa GIP ndi GLP-1 receptors
B. Njira yochitira: kupititsa patsogolo katulutsidwe ka insulin kagawo I ndi gawo II, kuchepetsa kuchuluka kwa glucagon.
II. Ntchito Zachipatala ndi Kuvomerezeka kwa FDA:
A. Chizindikiro: Kuwongolera kulemera kwanthawi yayitali kwa odwala onenepa kwambiri omwe ali ndi vuto lalikulu la kunenepa kwambiri kapena matenda okhudzana ndi kulemera
B. Chithandizo chothandizira kukonza glycemic control mwa akulu omwe ali ndi matenda a shuga a 2
Kuvomerezedwa ndi FDA ndi Eli Lilly mu 2022
III. Kuchita bwino pa Weight Management:
A. Kuchita bwino kofananiza:
Peresenti ya kuwonda: Mlingo wochepa (5mg), wapakatikati (10mg), ndi magulu apamwamba (15mg)
Avereji yochepetsera kunenepa m'magulu osiyanasiyana a mlingo
Kuyerekeza ndi gulu la placebo
Peresenti ya maphunziro omwe achepetsa thupi kuposa 20%
B. Mbiri yachitetezo: Kuchulukitsa kwa zoyipa poyerekeza ndi gulu la placebo
C. Poyerekeza ndi mankhwala ena ochepetsa thupi:
Orlistat (yowonjezera): Kusiyana kwa maperesenti ochepetsa thupi
IV. Njira Yowongolera Glycemic ndi Kuchepetsa Kuwonda:
A. Kutsegula kwa GLP-1 ndi GIP zolandilira
B. Kuchepetsa chilakolako cha kudya ndi kuchepetsa kudya
Tirzepatide, monga wapawiri GLP-1 ndi GIP receptor agonist, imapereka kasamalidwe koyenera komanso kawongolero ka glycemic mwa odwala onenepa kwambiri omwe ali ndi kunenepa kwambiri kwa achikulire kapena zovuta zokhudzana ndi kulemera, komanso mwa anthu omwe ali ndi matenda amtundu wa 2. Njira yake yodalira glucose imathandizira katulutsidwe ka insulini ndikuchepetsa kuchuluka kwa glucagon. Ndi maperesenti ambiri ochepetsa thupi komanso mbiri yabwino yachitetezo, tirzepatide imadziwika ngati mankhwala amphamvu pakuwongolera kulemera kwanthawi yayitali. Kufufuza kwina ndi maphunziro azachipatala apitiliza kufufuza mapindu omwe angakhale nawo komanso kugwiritsa ntchito mankhwalawa.
Kuti tipereke chidziwitso chabwinoko cha malonda, titha kusintha kapisozi ndi zinthu zamadzimadzi, malinga ndi zomwe mukufuna.
Titha kusintha mlingo: 500mg/kapisozi, 550mg/kapisozi, 600mg/kapisozi.
Titha kusintha mwamakonda ma CD: 60 zisoti / botolo, 90 zisoti / botolo, 120 zisoti / botolo.
Titha kusintha zipolopolo za kapisozi ndi mitundu: zipolopolo za kapisozi zobzala, zipolopolo za kapisozi za gelatin.
Kufotokozera
