Triptorelin, decapeptide yopangidwa ndi analogi ya gonadotropin-release hormone (GnRH), yadziwika bwino pazachipatala. Amagwiritsidwa ntchito pazowonetsa zosiyanasiyana, kuphatikiza chithandizo cha endometriosis, fibroids, khansa ya prostate, kutha msinkhu, kusabereka. Triptorelin imagwira ntchito poyambitsa katulutsidwe ka ma gonadotropins kenako ndikuchepetsa zolandilira gonadotropin-kutulutsa mahomoni, zomwe zimapangitsa kuchepa kwa nthawi yayitali kwa gonadotropin.
Triptorelin amawonetsa mitundu ingapo yamachiritso. Kwa amayi, amagwiritsidwa ntchito pochiza endometriosis, uterine fibroids, ndi kusabereka. Kuwongolera kosalekeza kwa Triptorelin kumalepheretsa kupanga estradiol, zomwe zimatsogolera ku kuponderezedwa kwa ectopic endometrial tishu mu endometriosis. Kuonjezera apo, kafukufuku wasonyeza kuchepa kwakukulu kwa kukula kwa uterine fibroids, ndi odwala ambiri omwe amakumana ndi amenorrhea mwezi woyamba wa chithandizo. Kwa kusabereka, triptorelin imalepheretsa katulutsidwe ka gonadotropins, kuwongolera kapangidwe ka follicle ndikuwonjezera kuchuluka kwa ma follicles, potero kumawonjezera mwayi wa njira zothandizira bwino zoberekera monga umuna wa in vitro.
Kwa amuna, triptorelin imagwiritsidwa ntchito kwambiri pochiza khansa ya prostate. Zimagwira ntchito poyamba kuonjezera magazi a luteinizing hormone (LH) ndi follicle-stimulating hormone (FSH) , zotsatiridwa ndi kuchepa kwa mahomoniwa komanso kuchepa kwa testosterone m'magazi. Kuchepetsa kwa testosterone uku kumathandiza kuchiza khansa ya prostate ndi zizindikiro zake. Jakisoni wa Triptorelin wakhalanso wothandiza pochiza kutha msinkhu, kulepheretsa pituitary hypersecretion ya gonadotropins ndi ma hormone normalizing.
Njira zogwirira ntchito za triptorelin zimaphatikizapo kuponderezedwa kwa katulutsidwe ka gonadotropin ndi kuletsa kwachindunji kwa gonadotropic pochotsa zolandilira zotumphukira za GnRH. Kafukufuku wa zinyama ndi anthu awonetsa zolepheretsa za kugwiritsiridwa ntchito kwa triptorelin kosatha pa gonadotropin secretion, zomwe zimapangitsa kuti ntchito ya testicular ndi ovarian iwonongeke. Kuchita bwino kwa Triptorelin kumawonetseredwanso ndikusintha kwachipatala kwazizindikiro monga dysmenorrhea, kupweteka kwa m'chiuno kosatha, komanso kupweteka panthawi yogonana.
Timapereka njira zosiyanasiyana zosinthira makonda kuti musankhe
Jekeseni wa Triptorelin: 0.1 mg/1 ml.
Jekeseni wa Triptorelin wotalikirapo: 3.75 mg; 11.25 mg; 22.5 mg.
Triptorelin pamoate ya jakisoni: 15 mg pa botolo (lokhala ndi botolo limodzi la 2 ml zosungunulira). Ngati muli ndi zosowa zina, mutha kulumikizana nafe ndipo tidzakupatsirani ntchito zosintha mwachangu komanso zolondola.
Monga analog yamphamvu ya gonadotropin, Triptorelin imapereka njira zingapo zothandizira amuna ndi akazi. Kutha kwake kuwongolera kuchuluka kwa mahomoni ndikuletsa katulutsidwe ka gonadotropin kwatsimikizira kukhala kothandiza pakuwongolera zinthu monga endometriosis, uterine fibroids, khansa ya prostate, kutha msinkhu, komanso kusabereka. Ndi mphamvu zake zachipatala komanso zosinthika, triptorelin ikupitiriza kuthandizira kwambiri pamunda wa mankhwala obereketsa ndi oncology.Kumvetsetsa njira zogwirira ntchito ndi kukonzekera komwe kulipo kwa triptorelin kumathandiza akatswiri a zaumoyo kuti azitha kukonza mapulani a chithandizo kwa wodwala aliyense.
