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Vincristine Sulfate Powder Vincristine Purity Vincristine CAS 57-22-7
Kufotokozera Mwatsatanetsatane
Vincristine ndi ufa wonyezimira wonyezimira komanso wosasungunuka m'madzi, koma umasungunuka m'madzi osungunuka. Ndi alkaloid yochitika mwachilengedwe yochokera ku chomera cha Madagascar periwinkle (Catharanthus roseus) . .
Vincristine ndi inhibitor ya microtubule yomwe imasokoneza mapangidwe a ma microtubules, omwe ndi zigawo zofunika kwambiri za cytoskeleton ya selo. Mwa kumanga tubulin, amalepheretsa kusonkhana kwa ma microtubules, zomwe zimachititsa kuti mitotic imangike ndi kufa kwa maselo m'maselo ogawanika. Vincristine imathandiza makamaka polimbana ndi maselo a khansa omwe amagawanika mofulumira.Machipatala a vincristine amaphatikizapo kuchiza matenda osiyanasiyana monga acute lymphoblastic leukemia(ALL),Hodgkin's and non-Hodgkin's lymphomas,zotupa za ana ndi akuluakulu olimba,neuroblastoma,ndi rhabdomyosarcoma.Vincristine amagwiritsidwa ntchito nthawi zambiri. kuphatikiza ndi mankhwala ena a chemotherapeutic monga gawo lamankhwala opangira mankhwala ambiri, omwe amadziwika kuti kuphatikiza mankhwala amphamvu amphamvu amphamvu.
Kuphatikiza pa kugwiritsidwa ntchito kwake koyamba pochiza khansa, vincristine yawonetsanso mphamvu pakuwongolera zinthu zina zomwe si za oncological. Amagwiritsidwa ntchito pochiza idiopathic thrombocytopenic purpura (ITP), matenda omwe amadziwika ndi kuchepa kwa mapulateleti. ,vincristine yawonetsa kuthekera pakuwongolera matenda osiyanasiyana am'mitsempha, kuphatikiza kutupa kosalekeza kwa demyelinating polyneuropathy(CIDP) ndi matenda a autoimmune neuropsychiatric okhudzana ndi matenda a streptococcal(PANDAS).
Kuphatikiza apo, vincristine's anti-angiogenic properties zapangitsa kuti afufuze momwe angagwiritsire ntchito pochiza matenda osiyanasiyana ochulukirachulukira, kuphatikiza matenda a shuga a retinopathy komanso kuwonongeka kwa macular okhudzana ndi ukalamba. Mwachidule, vincristine, yochokera ku chomera cha Madagascar periwinkle, ndi chinthu chamtengo wapatali chotsutsana ndi khansa chomwe chimasokoneza mapangidwe a microtubule ndikupangitsa kufa kwa maselo m'maselo ogawa. ntchito zosiyanasiyana zachipatala zikuphatikizapo kuchiza khansa ya m'magazi, lymphoma, zotupa zolimba, ndi zina zomwe si za oncological.
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