Abaloparatide, igurishwa ku izina rya Tymlos, ni ikigereranyo cyoguhuza imisemburo ya parathiyide ya poroteyine (PTHrP). Nibintu bya anabolike bikoreshwa mu kuvura osteoporose, indwara irangwa namagufa yacitse intege ndetse no kongera ibyago byo kuvunika. Abaloparatide yerekanwa ku bagore n'abagabo bafite igihe cyo gucura ndetse n'abagabo barwaye osteoporose bafite ibyago byinshi byo kuvunika, ndetse no ku bananiwe cyangwa batihanganira ubundi buryo bwo kuvura osteoporose. Muguhitamo gukora imisemburo ya parathiyide 1 reseptor (PTH1R), abaloparatide itera gukura kwamagufwa kandi ikongera ubwinshi bwamagufwa.
Abaloparatide ni 34 ya aminide acide ya synthique ya PTHrP, hamwe na 41% homology ya hormone parathiyide (PTH) (1-34) na 76% homology kuri PTHrP (1-34). Uburyo bwibikorwa bukubiyemo guhuza PTH1R, reseptor ya G ya proteine ikomatanya igaragara muri osteoblasts na osteocytes. Muguhuza cyane na RG ihuza imiterere ya PTH1R, abaloparatide itanga inzibacyuho yamanuka ya cyclic AMP yerekana igisubizo, biganisha kumuhanda wa anabolike.
Mu bagore nyuma yo gucura bafite osteoporose bafite ibyago byinshi byo kuvunika, abaloparatide nuburyo bwiza bwo kuvura. Ifasha kongera amagufwa no kugabanya ibyago byo kuvunika. Byongeye kandi, abaloparatide irashobora gukoreshwa kugirango yongere ubwinshi bwamagufwa kubagabo barwaye osteoporose yibanze cyangwa hypogonadal bafite ibyago byinshi byo kuvunika cyangwa kunanirwa cyangwa kutihanganira ubundi buvuzi buboneka.
Byongeye kandi, abaloparatide itanga inyungu kubagabo nabagore barwaye osteoporose ijyanye no kuvura glucocorticoid ihoraho. Aba bantu bafite ibyago byinshi byo kuvunika kubera gukoresha glucocorticoide igihe kirekire. Abaloparatide irashobora gufasha kunoza imbaraga zamagufwa no kugabanya ibyago byo kuvunika muri aba baturage.
Abaloparatide, igereranya rya PTHrP, nubuvuzi bwingirakamaro kuri osteoporose. Imiterere ya anabolike itera gukura kw'amagufwa no kongera ubwinshi bw'amagufwa, bikagabanya ibyago byo kuvunika. Yerekanwa ku bagore n'abagabo nyuma yo gucura bafite ibyago byinshi byo kuvunika, kimwe n'abantu bananiwe cyangwa batihanganira ubundi buvuzi bwa osteoporose. Muguhitamo gukora PTH1R, abaloparatide itera inzira ya anabolike yerekana inzira yongera ubuzima bwamagufwa. Ikoreshwa ryayo muri osteoporose ijyanye no kuvura glucocorticoid sisitemu ihoraho itanga uburyo bwingenzi bwo kuvura kubantu bafite ibyago byinshi byo kuvunika. Abaloparatide igira uruhare runini mugukemura ibibazo by’abarwayi barwaye osteoporose no kuzamura amagufwa yabo n’ubuzima bwiza.
