Arecoline hydrobromide Therapeutic Potential muri sisitemu yo hagati

Igiciro Reba: USD15-20 / g

izina RY'IGICURUZWA Arecoline
URUBANZA No. 300-08-3
MF C8H14BrNO2
MW 236.109
EINECS 206-087-3
Coefficient ya acide (pka) 6.84 (kuri 25 ℃)
Ingingo yo gushonga 171-175 ° C.

Twandikire

ibicuruzwa birambuye

Ibisobanuro birambuye

Arecoline, alkaloide nyamukuru ikora iboneka mu mbuto ya areca, yitabiriwe n’ubushobozi bwayo bwo kuvura mu gukemura ibibazo by’indwara zo mu mutwe no kugabanya indwara zo mu gifu. Iyi ngingo igamije gutanga incamake yuburyo bwuburyo bwibikorwa bya arecoline muri sisitemu zitandukanye z'umubiri, harimo umunwa wo mu kanwa, sisitemu yo hagati yo hagati, sisitemu y'umutima n'imitsi. Byongeye kandi, imikorere yubuzima ningaruka zishobora kwangiza za arecoline zizashakishwa. Hanyuma, ikoreshwa rya arecoline mubyokurya byubuzima, imiti, hamwe no kwisiga.

Arecoline, aside nicotinike ishingiye kuri parasimpathomimetic yoroheje ya alkaloide, cyane cyane ikora nka agoniste igice cya reseptor ya muscarinic acetylcholine. Irerekana ingaruka za parasimpatique aho kubabaza nicotinic acetylcholine yakira nka nikotine. Arecoline irabuza kandi AMPK (adenosine monophosphate-ikora protein kinase) binyuze mu kubyara ubwoko bwa ogisijeni ikora (ROS) mu bwoko butandukanye.

Ingaruka kuri Sisitemu zitandukanye z'umubiri:

Sisitemu ya Nervous: Arecoline itera kwishima, ikongera imyigire no kwibuka, kandi igabanya ibimenyetso byo kwiheba na sizizofrenia. Irashobora kandi guhindura gutakaza kwibuka biterwa na scopolamine.

Sisitemu yumutima nimiyoboro: Arecoline ikora nka vasodilator, yongera plasma nitric oxyde, eNos, na mRNA imvugo, ikanagaragaza anti-trombose ningaruka zo kurwanya aterogene. Iragabanya kandi IL-8 nibindi bintu.

Sisitemu ya Endocrine: Arecoline itera ingirabuzimafatizo za Leydig, bigatuma testosterone yiyongera. Ikora hypothalamic-pituitar-adrenal (HPA) axis, itera imisemburo ya corticotropine irekura imisemburo (CRH). Byongeye kandi, ifasha gukumira imikorere mibi ya selile pancreatic beta iterwa no gufata fructose nyinshi.

Sisitemu y'ibiryo: Arecoline itera sisitemu igogora binyuze mumikorere ya reseptor ya muscarinic. Yongera kugabanuka kwimitsi ya gastricike yoroshye hamwe nuduce twimitsi ya duodenum, ileum, na colon.

Imikorere yubuzima nibisabwa:

Analgesia na Central Nervous System Ingaruka: Arecoline hydrobromide yerekana imiti idakira kandi igira ingaruka zihamye kuri sisitemu yo hagati.

Ubuzima bwuruhu: Arebine hydrobromide itera metabolisme yuruhu kandi ikerekana ubushobozi bwo kuvura ibisebe byuruhu nizindi ndwara zuruhu.

Ingaruka ziterwa na Diuretique: Hydrobromide ya Arecoline ikuraho ubushyuhe, ikangiza, ikuraho ububobere no kubyimba, kandi ifite imiterere ya diureti.

Antibacterial and Dissolving Amabuye: hydrobromide ya Arecoline yerekana imiterere ya antibacterial hamwe nubushobozi bwo gushonga amabuye.

Umuyoboro w'amaraso Gukomeza no kuzenguruka kw'amaraso: Hydrobromide ya Arecoline ifasha gushimangira imiyoboro y'amaraso no guteza imbere umuvuduko w'amaraso.

Porogaramu:

Ibyokurya byubuzima byubuzima: Arecoline irashobora gukoreshwa nkibigize ibiryo byubuzima byubuzima byibanda kubikorwa byihariye byubuzima, nko kongera ubwenge cyangwa ubuzima bwuruhu.

Imiti ya farumasi: Arecoline irashobora gukoreshwa muburyo bwa farumasi, cyane cyane mukuvura indwara zo mumutwe cyangwa nk'imiti igabanya ubukana.

Gutegura kwisiga: Gutezimbere uruhu rwa Arecoline metabolisme hamwe nibishobora gukira ibikomere bituma iba umukandida wimyitozo yo kwisiga, cyane cyane yibasira ibisebe byuruhu cyangwa izindi ndwara ziterwa nuruhu.

Arecoline, alkaloide ikora iboneka mu mbuto ya areca, yerekana ingaruka zitandukanye zo kuvura kandi ifite porogaramu muri sisitemu zitandukanye z'umubiri. Uburyo bwibikorwa byabwo bwahujwe cyane cyane binyuze mumitsi ya muscarinike kandi ikerekana ingaruka za parasimpatique. Mugihe arecoline yerekana amasezerano mugukemura ibibazo byubuzima runaka, ni ngombwa gusuzuma ingaruka zishobora guterwa nuburozi hamwe na kanseri itera kanseri ijyanye no kuyikoresha. Vugana natwe niba bikenewe.

Ibisobanuro