Kubyara imburagihe bitera ingaruka zikomeye nuburemere kumiryango ndetse na societe muri rusange. Nkigisubizo, gukumira no kuvura kubyara imburagihe bifite akamaro kanini cyane. Tocolytics, nka atosiban, igira uruhare runini mugutinda imirimo itaragera no kurinda akayoya. Atosiban, cyclic nonapeptide na analogue ya oxytocine, ikora nka antagonist irwanya reseptor ya oxytocine muri nyababyeyi, decidua, na nyababyeyi. Muguhagarika kwikuramo nyababyeyi, atosiban yagaragaye nkigikoresho cyamavuriro gifite akamaro mukuvura kubyara imburagihe.
Atosiban, nka oxytocine hamwe na vasopressine V1A reseptor antagonist, itanga uburyo bwihariye bwo kubuza kwandura nyababyeyi. Guhuza imiterere hagati ya reseptor ya oxytocine na reseptor ya vasopressine V1A bisaba guhagarika icyarimwe inzira zombi zakira kugirango zibuze neza kwikuramo nyababyeyi. Bitandukanye nubundi tocolytike nka beta-agoniste, inzitizi za calcium, hamwe na prostaglandine synthase inhibitor, antosism ya kabiri ya reseptor ya atosiban ituma habaho gukumira neza kwandura kwa nyababyeyi. Oxytocine, usibye gukurura ububabare bwa nyababyeyi, inashimangira umusaruro no kurekura PGF2α, ibyo bikaba bigira uruhare runini mu kugabanya imitsi ya nyababyeyi. Kuba Atosiban ikunda cyane reseptor ya oxytocine na vasopressine V1A ihuza aba reseptors, bikabuza inzira inzira ya oxytocine na vasopressine. Ubu buryo buganisha ku kugabanuka kwa nyababyeyi.
Kimwe mu byiza byingenzi bya atosiban ningaruka zacyo nkeya. Mugihe havuzwe tachycardia yoroheje, gukomera mu gatuza, kuzunguruka, kubabara umutwe, isesemi, na dyspnea, izi ngaruka muri rusange ntizisaba ubuvuzi budasanzwe, kandi ibiyobyabwenge ntibikunze guhagarikwa kubera ingaruka mbi. Byongeye kandi, atosiban ifite plasma yigihe gito yubuzima, igabanya kwirundanya kwayo mu nda no kugabanya ibyago byingaruka mbi ku mwana. Ibigeragezo by’amavuriro byagaragaje ingaruka za atosiban mu gihe cyo gutwita ku bagore bafite ibyumweru birenga 28 byo gutwita. Mubigeragezo byinshi, impumyi ebyiri, igenzurwa na platbo, kuvura atosiban byatumye inda yongerwa kugeza kuminsi 7. Ikigereranyo cyamavuriro kigereranya cyerekanye kandi atosiban kugira ibikorwa bigereranywa na tocolytique na ritodrine mugihe byihanganirwa cyane cyane mubyerekeranye n'ingaruka z'umutima-mitsi. Ibyavuye mu bushakashatsi byerekana ubushobozi bwa atosiban nkumuti mwiza kandi wihanganirwa neza.
Atosiban, nka vasopressine irushanwa / oxytocine reseptor antagonist, igira uruhare runini mukurinda kubyara imburagihe. Ubushobozi bwayo bwo guhagarika ububabare bwa nyababyeyi binyuze muburyo bubiri bwa reseptor antagonism bituma iba igikoresho cyagaciro cyo gutinza imirimo itaragera. Ingaruka ntoya, plasma ngufi yubuzima, hamwe no kwegeranya kugarukira mu nda bikomeza kunoza imiterere yumutekano. Byongeye kandi, ubushobozi bwa atosiban mugutezimbere ibisubizo byo gutwita kubarwayi bafite kunanirwa kwatewe inshuro nyinshi batewe na IVF-ET byerekana uburyo bwinshi n'ubushobozi mubuvuzi bw'imyororokere. Gukomeza ubushakashatsi no gukoresha ivuriro rya atosiban bishobora kugira uruhare runini mu kugabanya umutwaro wo kubyara imburagihe ku miryango no muri sosiyete.
