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Bivalirudin: Inhibitori ya Thrombin ihindagurika kugirango irwanya Anticoagulation nziza
Ibisobanuro birambuye
Bivalirudin ni peptide ya sintetike 20 isigara ikora nka inhibitori idasubirwaho ya trombine, enzyme yingenzi igira uruhare mu maraso. Muguhuza urubuga rukora rwa trombine, bivalirudin irinda ihinduka rya fibrinogen na fibrin, intambwe ikomeye mugushinga trombus. Biyobowe mumitsi, bivalirudin igira uruhare runini mukuvura anticoagulation. Nyamara, gukurikirana neza hematocrit, gukora igice cya tromboplastine igice (aPTT), igipimo mpuzamahanga gisanzwe (INR), hamwe numuvuduko wamaraso birakenewe kubera ubushobozi bwabyo bwo guhagarika amaraso.
Bivalirudin yerekana ingaruka zibuza gukomera no gukomera kwa trombine muri vitro. Icyangombwa, iyi ngaruka yo guhagarika ikomeza kutagerwaho nibicuruzwa byasohotse. Hamwe nuburyo bukabije, bivalirudin irashobora kwagura plasma aPTT, igihe cya trombine, nigihe cya prothrombine mubintu bisanzwe byabantu. Ibi biranga bituma bikoreshwa cyane cyane mugukoresha coronary intervention (PCI) kubarwayi bafite angina idahindagurika.
Indwara ya Cardioembolic, izwi kandi ku izina ry'umutima, ibaho iyo emboli ikomoka ku mutima no mu bwoko bwa Aortic arch igenda mu maraso, biganisha ku bwonko bwo mu bwonko ndetse no gukora nabi mu bwonko. Indwara z'umutima, ugereranije n'indwara ziterwa na ischemic zindi etiologiya, zikunda kuba ingorabahizi mubijyanye nimpamvu zishingiye, zikomeye cyane mubijyanye no kwerekana, zifite imenyekanisha ribi, kandi nigipimo kinini cyo kugaruka. Hafi 70% yimitsi yose ifite inkomoko yumutima biterwa na fibrillation atriel (AF). Ubuvuzi bwa Anticoagulant bukwiranye nuburwayi bwumurwayi ni ngombwa kugirango hirindwe icyiciro cya kabiri cy’indwara zifata umutima ziterwa na AF.
Iyo usuzumye ikoreshwa rya bivalirudin, ni ngombwa kuzirikana ibisabwa kugirango ukurikirane umutekano wumurwayi mwiza. Impinduka za hematocrit, aPTT, INR, n umuvuduko wamaraso zigomba gukurikiranirwa hafi kugirango hamenyekane ingorane zose zishobora guterwa no guhagarara kwamaraso. Gukurikirana buri gihe bituma inzobere mu buvuzi zihindura dosiye kandi ikemeza ko umurwayi yakira urwego rukwiye rwa anticoagulation.
Bivalirudin, nka inhibitori ya trombine idasubirwaho, igira uruhare runini mu kuvura anticoagulation. Muguhagarika trombine, irinda ishingwa rya fibrin no gukurikiraho. Ibi bituma ihitamo neza mugukoresha imitsi ya coronary intervention, cyane cyane kubarwayi bafite angina idahindagurika.
Niba hari ibyo ukeneye kuri Bivalirudin, nyamuneka ntutindiganye kutwandikira kubiciro byiza.
Niba hari ibyo ukeneye kuri Bivalirudin, nyamuneka ntutindiganye kutwandikira kubiciro byiza.
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