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Memantine HCl 99% Isuku ivura indwara ya Alzheimer Uruganda
Ibisobanuro birambuye
Memantine hydrochloride, yakozwe na Merz mu Budage, ni imiti mishya yabanje kugamije kuvura indwara yo guta umutwe. Ikora nka antagonist N-methyl-D-aspartate (NMDA) reseptor antagonist, ihagarika reseptor ya NMDA no kugabanya hyperexcitability ya glutamate. Ubu buryo bugamije kunoza imikorere yubwenge, kwirinda apoptose, no kongera kwibuka. Pethidine hydrochloride yemejwe na komite y’ibihugu by’i Burayi ishinzwe imiti y’ubuvuzi (CPMP) kugira ngo ivure indwara ya Alzheimer yoroheje kandi ikabije mu 2002. Ubushakashatsi bw’inyongera bwerekanye kandi akamaro k’abarwayi bafite indwara ya Alzheimer yoroheje cyangwa yoroheje.
Hydrochloride ya Memantine, ingirakamaro muri pethidine hydrochloride, ni isano iri hagati, irwanya NMDA reseptor antagonist. Mugihe ikoreshwa ryibanze ari kuvura indwara ya Alzheimer, ryakozweho ubushakashatsi bwimbitse kandi rikoreshwa mu zindi ndwara zifata imyanya ndangagitsina nka epilepsy, migraine, n'indwara zo mu mutwe zirimo indwara ya bipolar na schizofrenia. Indwara yo guta umutwe ikomeje kwibandwaho cyane mu gushyira mu bikorwa memantine, kandi yerekanye inyungu zitandukanye mu ndwara ya Alzheimer, guta umutwe, no guta umutwe hamwe n’umubiri wa Lewy. Ntabwo iteza imbere imikorere yubwenge gusa ahubwo inakemura ibimenyetso byimyitwarire naba psychologue yo guta umutwe (BPSD), nka salusiyo, kwibeshya, guhagarika umutima, gutera, no kurakara.
Usibye ingaruka zagize ku guta umutwe, hakozwe ubushakashatsi kuri memantine ku ngaruka zayo ku zindi ndwara zifata ubwonko. Abarwayi bafite igicuri bakunze guhura na deficits ya cognitive, kandi memantine yerekanye ubushobozi mukugabanya izo defisite. Byongeye kandi, indwara ya Alzheimer ubwayo ni yo ishobora gutera indwara, kandi abantu barwaye iyi ndwara bafite ibyago byinshi byo kwandura igicuri ugereranije n'abatayifite. Muguhagarika neuroexcitotoxicity ifitanye isano na NMDA reseptor hyperactivation, memantine irashobora kugira ingaruka za antiepileptic.
Byongeye kandi, memantine yakozwe mu rwego rwo kuvura imirasire y’ubwonko bwose (WBRT), gukomeretsa ubwonko (TBI), na stroke. WBRT irashobora gutera ubumuga bwo kutamenya, kandi memantine yerekanwe gutinda gutangira no kunoza imikorere yubwenge. Imiterere yihariye ya farumasi ya memantine yatumye ubushakashatsi bwayo butandukanye bwindwara zifata ubwonko.
Ubushakashatsi buherutse gukorwa bwerekanye ko hashobora gukoreshwa memantine mu kugabanya ingaruka za neurotoxique ya COVID-19 no kubuza kwandura virusi, byerekana agaciro kayo k’ubuvuzi.
Hydrochloride ya Memantine, cyane cyane ingirakamaro ya memantine hydrochloride, yerekanye imbaraga mu kuvura indwara yo guta umutwe, cyane cyane indwara ya Alzheimer. Uburyo bwihariye bwa NMDA reseptor antagonist butuma habaho kunoza imikorere yubwenge no gucunga ibimenyetso byimyitwarire nibitekerezo bifitanye isano no guta umutwe. Byongeye kandi, memantine yerekana amasezerano mu zindi ndwara zifata ubwonko nka epilepsy, migraine, hamwe nubumuga bwo kutamenya nyuma yimirasire. Ubushakashatsi burimo gukorwa bukomeje gushakisha agaciro kavuriro ka memantine mubihe bitandukanye byubwonko.
Wibuke kuvugana natwe kugirango tuyobore ubuzima bwiza.
Wibuke kuvugana natwe kugirango tuyobore ubuzima bwiza.
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