Rosuvastatin antilipemic agent Rosuvastatin ivura dyslipidemiya

Rosuvastatin ibuza enzyme hydroxymethylglutaryl-CoA reductase mu mwijima, igabanya synthesis ya cholesterol kandi igabanya cholesterol ya serumu na triglyceride. Byongeye kandi, Rosuvastatin yongerera umwijima gufata no kugabanuka kwa cholesterol ya lipoprotein nkeya (LDL-C), mu gihe kandi izamura urugero rwa cholesterol ya lipoprotein nyinshi (HDL-C). Usibye ingaruka zayo zigabanya lipide, Rosuvastatin yerekanye ko ifite anti-atherosclerotic, anti-inflammatory, antioxidant, plaque ituje, kandi inoze imikorere ya endoteliyale.

Rosuvastatin ikorwa hifashishijwe fermentation ya Aspergillus terreus cyangwa ikoresheje synthesis. Iyo imaze kwinjizwa, ihinduka cyane mu mwijima igahinduka metabolite zitandukanye, harimo na metabolite ikora ibuza HMG-CoA reductase. Ibiyobyabwenge na metabolite byayo bisohoka cyane cyane mumyanda, hamwe na bike bisohoka mu nkari.