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Tirzepatide Dual GLP-1 na GIP Receptor Agonist yo gucunga ibiro no kugenzura Glycemic
Ibisobanuro birambuye
Tirzepatide ni imiti mishya ikoreshwa mugucunga ibiro birebire kubarwayi bafite ibiro byinshi bafite umubyibuho ukabije cyangwa ingaruka ziterwa n'uburemere. Ni glucose iterwa na agonist ya glucagon polypeptide (GIP) hamwe na glucagon imeze nka peptide-1 (GLP-1). Byemejwe na FDA mu 2022, tirzepatide ikomatanya ingaruka za proinsuline ebyiri zinjira muri molekile imwe, byongera imisemburo ya insuline no kugabanya urugero rwa glucagon. Iyi ngingo irasobanura uburyo bwibikorwa, imikorere yubuvuzi, hamwe numutekano wumutekano wa tirzepatide nkubuvuzi bufatika bwo kugabanya ibiro no kunoza uburyo bwa glycemic kubarwayi barwaye diyabete yo mu bwoko bwa 2.
I. Gusobanukirwa Tirzepatide:
A. Glucose-iterwa na agonist ya GIP na GLP-1
B. Uburyo bwibikorwa: kuzamura icyiciro cya I nicyiciro cya II insuline isohoka, kugabanya urugero rwa glucagon
II. Gukoresha Ivuriro no Kwemeza FDA:
A. Kwerekana: Gucunga igihe kirekire kubarwayi bafite ibiro byinshi bafite umubyibuho ukabije cyangwa ingaruka ziterwa n'uburemere
B. Ubuvuzi bujyanye no kunoza igenzura rya glycemic kubantu bakuze barwaye diyabete yo mu bwoko bwa 2
C. Kwemeza FDA no kwamamaza na Eli Lilly muri 2022
III. Ingaruka mu gucunga ibiro:
A. Kugereranya imikorere:
Ijanisha ryo kugabanya ibiro: Dose-5 (5mg), ikigereranyo cyo hagati (10mg), hamwe nitsinda ryinshi (15mg)
Impuzandengo yo kugabanya ibiro kwijana mumatsinda atandukanye
Gereranya nitsinda rya placebo
Ijanisha ryamasomo agera kugabanuka kurenza 20%
B. Umwirondoro wumutekano: Inshuro zingaruka mbi ugereranije nitsinda rya placebo
C. Gereranya nindi miti igabanya ibiro:
Orlistat (hejuru-ya-konte): Itandukaniro mugutakaza ibiro
IV. Uburyo bwo kurwanya Glycemic no kugabanya ibiro:
A. Gukora GLP-1 na GIP yakira
B. Kurwanya ubushake bwo kurya no kugabanya ibiryo
Tirzepatide, nka GLP-1 na GIP reseptor agonist, itanga imicungire myiza yuburemere no kunoza uburyo bwa glycemic kubarwayi bafite ibiro byinshi bafite umubyibuho ukabije cyangwa ingaruka ziterwa nuburemere, ndetse no kubantu bafite diyabete yo mu bwoko bwa 2. Uburyo bwa glucose bushingiye kubikorwa byongera insuline kandi bikagabanya urugero rwa glucagon. Hamwe no gutakaza ibiro ku ijana hamwe numwirondoro mwiza wumutekano, tirzepatide igaragara nkumuti ukomeye wo gucunga ibiro birebire. Ubundi bushakashatsi nubushakashatsi bwubuvuzi bizakomeza gushakisha inyungu zishobora gukoreshwa nibi biyobyabwenge.
Kugirango dutange ubunararibonye bwubucuruzi ， turashobora guhitamo capsule nibicuruzwa byamazi, dukurikije ibyo ukeneye.
Turashobora guhitamo dosiye: 500mg / capsule, 550mg / capsule, 600mg / capsule.
Turashobora guhitamo ibipfunyika: ingofero 60 / icupa, ingofero 90 / icupa, 120 cap / icupa.
Turashobora guhitamo capsule ibishishwa n'amabara: ibimera bya capsule, ibishishwa bya gelatin.
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