0102030405
Ifu ya Vincristine Ifu ya Vincristine Yera Vincristine CAS 57-22-7
Ibisobanuro birambuye
Vincristine ni ifu yera ya kirisiti ya kirisiti.Ntabwo ishobora gushonga mumazi, ariko irashonga mumashanyarazi amwe.Ikigo cyera ntigifite impumuro nziza kandi mubisanzwe kibikwa ahantu humye, hijimye mugihe cy'ubushyuhe bugenzurwa kugirango gikomeze guhagarara neza. Nibisanzwe bisanzwe alkaloide ikomoka ku gihingwa cya Madagasikari periwinkle (Catharanthus roseus) .Imiterere y’imiti isa n'iya vinblastine, indi vinca alkaloide.Vincristine ikoreshwa cyane mu kuvura ubwoko butandukanye bwa kanseri, harimo na leukemia, lymphoma, n'ibibyimba bikomeye. .
Vincristine ni inhibitor ya microtubule ihungabanya ishingwa rya microtubules, zikaba aribyingenzi bigize cytoskeleton ya selile.Mu guhuza tubuline, birinda guterana kwa microtubules, biganisha ku gufatwa kwa mitoto no gupfa kwakagari mugutandukanya ingirabuzimafatizo.Ubu buryo bwibikorwa butuma selile zikora. vincristine ifite akamaro kanini mukurwanya kanseri ya kanseri igabanya vuba.Gukoresha imiti ya vincristine harimo kuvura indwara mbi zitandukanye nka lymphoblastique acute lymphoblastique (BYOSE), Lymphoma ya Hodgkin na non-Hodgkin, ibibyimba bikomeye byabana ndetse nabakuze, neuroblastoma, na rhabdomyosarcoma. Vincristine ikoreshwa kenshi. ifatanije nubundi buryo bwa chimiotherapeutique nkibice bigize gahunda yo kuvura imiti myinshi, hamwe bizwi nka chimiotherapie.
Usibye kuba ikoreshwa ryambere mu kuvura kanseri, vincristine yanagaragaje imikorere mu micungire y’ibihe bimwe na bimwe bitari oncologiya.Bikoreshwa mu kuvura idiopathic thrombocytopenic purpura (ITP), indwara ya autoimmune irangwa no kubara kwa platine nkeya.Ikindi kandi , vincristine yerekanye ubushobozi mu micungire y’imiterere itandukanye y’imyakura, harimo na inflammatory inflammatory demyelinating polyneuropathie (CIDP) hamwe n’indwara ziterwa n’abana bato autoimmune neuropsychiatricique zifitanye isano n'indwara ziterwa na streptococcale (PANDAS).
Byongeye kandi, imiterere ya anti-angiogenic ya vincristine yatumye habaho ubushakashatsi ku mikoreshereze ishobora gukoreshwa mu kuvura indwara zitandukanye zikwirakwizwa, harimo na retinopathie diabete ndetse n’imyaka iterwa na macular degeneration.Nyamara, vincristine izwi cyane cyane ku ruhare rwayo mu kuvura kanseri, no kuyikoresha mu ubundi buzima bwubuvuzi bufatwa nkibidakwiye kandi bisaba gusuzuma neza ingaruka zishobora guterwa ninyungu.Mu ncamake, vincristine, ikomoka ku gihingwa cya Madagasikari periwinkle, ni ikintu cyiza cyo kurwanya kanseri kibangamira imiterere ya microtubule kandi gitera urupfu mu ngirabuzimafatizo. mubuvuzi bugari burimo kuvura indwara ya leukemia, lymphoma, ibibyimba bikomeye, hamwe nibibazo bimwe na bimwe bitari onkologiya.Mu gihe ikoreshwa ryambere ryayo ari kuvura kanseri, ubushakashatsi burimo gukorwa bukomeje gushakisha ubushobozi bwabwo mubuvuzi butandukanye.
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