Arecoline hydrobromide Therapeutic Potential in Central nervous system

Faʻamatalaga Tau: USD15-20/g

Igoa Oloa Arecoline
CAS Nu. 300-08-3
MF C8H14BrNO2
MW 236.109
EINECS 206-087-3
Su'ega oona (pka) 6.84(i le 25℃)
Liu liusuavai 171-175°C

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Arecoline, o le alkaloid galue malosi o loʻo maua i le areca nut, ua faʻaalia lona malosi faʻapitoa e foia ai faʻafitauli o le mafaufau ma faʻaitiitia ai maʻi o le manava. O lenei tusiga o loʻo faʻamoemoe e tuʻuina atu se otootoga faʻapitoa o le gaioiga o le gaioiga o le arecoline i le tele o tino, e aofia ai le gutu o le gutu, fatugalemu o le tino, cardiovascular system, ma le digestive system. E le gata i lea, o le a su'esu'eina galuega fa'alesoifua maloloina ma a'afiaga oona o le arecoline. Mulimuli ane, o le faʻaogaina o le arecoline i meaʻai faʻalesoifua maloloina, vailaʻau, ma teuteuga teuteu o le a talanoaina.

Arecoline, ole nicotinic acid-based mild parasympathomimetic stimulant alkaloid, e masani ona galue o se vaega agonist o muscarinic acetylcholine receptors. E fa'aalia ai a'afiaga parasympathetic nai lo le fa'ama'i tigaina o nicotinic acetylcholine receptors pei o le nicotine. Arecoline foi fa'alavelave AMPK (adenosine monophosphate-activated protein kinase) e ala i le fa'atupuina o ituaiga o okesene fa'afofoga (ROS) i ituaiga sela eseese.

Aafiaga i Faiga o Tino Eseese:

Faiga Nervous: Arecoline e fa'aosofia ai le fiafia, fa'aleleia le a'oa'oina ma le manatua, ma fa'aitiitia fa'ailoga o le atuatuvale ma le schizophrenia. E mafai foʻi ona toe faʻafoʻisia le leiloa o le mafaufau e mafua mai i le scopolamine.

Cardiovascular System: Arecoline galue o se vasodilator, faʻateleina le plasma nitric oxide, eNos, ma le mRNA faʻamatalaga, ma faʻaalia ai le anti-thrombosis ma le anti-atherogenic aafiaga. E faʻaitiitia ai foi le IL-8 ma isi mea.

Endocrine System: Arecoline e fa'aosofia ai sela o Leydig, e o'o atu ai i le maualuga o le testosterone. E faʻagaoioia le hypothalamic-pituitary-adrenal (HPA) axis, faʻaosofia le corticotropin-releasing hormone (CRH). E le gata i lea, e fesoasoani e puipuia le faʻaleagaina o sela beta pancreatic e mafua mai i le maualuga o le fructose intake.

Digestive System: Arecoline e faʻaosofia ai le faʻaogaina o meaʻai e ala i le faʻagaoioia o faʻamaʻi muscarinic. E fa'atuputeleina ai le fa'aitiitiga o maso lamolemole ga'o ma fasi maso o le duodenum, ileum, ma le kolone.

Galuega Fa'alesoifua maloloina ma Talosaga:

A'afiaga o le fa'ama'i ma le Central Nervous System: Arecoline hydrobromide o lo'o fa'aalia ai mea fa'ama'i ma e iai sona aafiaga fa'amautu i le fatugalemu o le tino.

Soifua Maloloina o le Pa'u: Arecoline hydrobromide e fa'aolaina ai le metabolism o le pa'u ma fa'aalia ai le gafatia e togafitia ai le ma'i pa'u ma isi fa'ama'i pa'u.

Detoxification ma le Diuretic Aafiaga: Arecoline hydrobromide e faʻamama ai le vevela, faʻamalo, aveese le susu ma le fula, ma e iai mea faʻamaʻi.

Antibacterial and Dissolving Stones: Arecoline hydrobromide e faʻaalia ai mea faʻamaʻi ma le mafai ona faʻamavaeina maʻa.

Fa'amalosia o le I'a o le Toto ma le Ta'amilosaga o le Toto: Arecoline hydrobromide e fesoasoani e fa'amalosia a'a toto ma fa'aola toto.

Talosaga:

Mea'ai Fa'asoifua maloloina: Arecoline e mafai ona fa'aogaina e fai ma mea e fa'aopoopo i mea'ai fa'alesoifua maloloina e fa'atatau i galuega fa'alesoifua maloloina fa'apitoa, e pei o le fa'aleleia o le mafaufau po'o le soifua maloloina o le pa'u.

La'au Talavai: Arecoline e ono mafai ona fa'aoga i vaila'au, aemaise ile togafitiga o fa'aletonu ole mafaufau po'o se vaila'au fa'ama'i.

Sauniuniga Teuga: O le fa'aleleia o le metabolism o le pa'u o le Arecoline ma mea e mafai ona fa'amālōlōina manu'a ua avea ai ma sui tauva mo sauniuniga teuteu, aemaise lava i latou o lo'o tulimata'ia le papala o le pa'u po'o isi ma'i e fa'atatau i le pa'u.

Arecoline, ole alkaloid malosi o lo'o maua ile areca nut, e fa'aalia ai a'afiaga fa'afoma'i eseese ma e fa'aoga ile tino. O ona fa'agaioiga o lo'o fa'atautaia muamua e ala i muscarinic receptors ma fa'aalia ai a'afiaga parasympathetic. E ui o le arecoline o loʻo faʻaalia le folafolaga i le faʻatalanoaina o tulaga faʻalesoifua maloloina, e taua le mafaufau i aʻafiaga oona ma mea faʻaleagaina e fesoʻotaʻi ma lona faʻaogaina. Faʻafesoʻotaʻi ma matou pe a manaʻomia.

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