Abaloparatide, inotengeswa pasi pezita rechiratidzo Tymlos, inogadzirwa analog yeparathyroid hormone-inoenderana protein (PTHrP). Inonzi anabolic agent inoshandiswa kurapa osteoporosis, chirwere chinoratidzwa nemapfupa asina simba uye kuwedzera kwengozi yekuputsika. Abaloparatide inoratidzwa kune vakadzi ve postmenopausal nevarume vane osteoporosis vari pangozi yakakura yekuputsika, pamwe chete neavo vakakundikana kana kusashivirira kune mamwe anowanikwa osteoporosis therapies. Nekusarudza kuita parathyroid hormone 1 receptor (PTH1R), abaloparatide inosimudzira kukura kwebhonzo uye inowedzera kuwanda kwemapfupa.
Abaloparatide i34 amino acid synthetic analog yePTHrP, ine 41% homology kune parathyroid hormone (PTH) (1-34) uye 76% homology kuPTHrP (1-34). Maitiro ayo ekuita anosanganisira kusunga kuPTH1R, G protein-coupled receptor inoratidzwa mu osteoblasts uye osteocytes. Nekuda kusunga kuRG conformational state yePTH1R, abaloparatide inounza kudzika kudzika pasi cyclic AMP kusaina mhinduro, inotungamira kune vanabolic kusaina nzira.
Muvakadzi vane postmenopausal vane osteoporosis vari panjodzi huru yekutyoka, abaloparatide inzira inoshanda yekurapa. Inobatsira kuwedzera mapfupa uye kuderedza ngozi yekuputsika. Uyezve, abaloparatide inogona kushandiswa kuwedzera simba remapfupa muvarume vane primary or hypogonadal osteoporosis avo vari pangozi yakakura yekuputsika kana kuti vakakundikana kana kuti vasingadi kune mamwe marapirwo aripo.
Uyezve, abaloparatide inopa mabhenefiti kune vese varume nevakadzi vane osteoporosis yakabatana neyakasimba systemic glucocorticoid therapy. Vanhu ava vari panjodzi huru yekutyoka nekuda kwekushandiswa kwenguva refu kweglucocorticoids. Abaloparatide inogona kubatsira kuvandudza simba remapfupa uye kuderedza ngozi yekuputsika muhuwandu huno.
Abaloparatide, analog yekugadzira yePTHrP, mushonga unokosha weosteoporosis. Its anabolic properties inokurudzira kukura kwepfupa uye kuwedzera mapfupa emapfupa, kuderedza ngozi yekuputsika. Inoratidzirwa kuvakadzi vane postmenopausal nevarume vari pangozi yakakura yekuputsika, pamwe chete nevanhu vakakundikana kana kusashivirira kune mamwe osteoporosis therapies. Nekusarudza kuita PTH1R, abaloparatide inokonzeresa nzira yevanabolic inosimudzira hutano hwemapfupa. Kushandiswa kwaro muosteoporosis yakabatana neyakagadziriswa systemic glucocorticoid therapy inopa yakakosha kurapwa sarudzo kune vanhu vari panjodzi huru yekutyoka. Abaloparatide inoita basa rakakosha mukugadzirisa zvinodiwa nevarwere vane osteoporosis uye kuvandudza hutano hwemapfupa uye hupenyu hwehupenyu.
