0102030405
Abarelix Ane Simba Gonadotropin-Releasing Hormone Antagonist yeProstate Cancer Treatment
Tsanangudzo Yakadzama
Abarelix, a synthetic decapeptide, anoratidza anesimba apikisi chiitiko chinopesana neakasikwa gonadotropin-inoburitsa mahormone (GnRH). Inonyanya kushandiswa kurapa varwere vane advanced symptomatic cancer cancer avo vasina kukodzera kukwikwidza luteinizing hormone-releasing hormone agonists kana kuvhiya castration. Nekudzivisa zvakananga secretion ye luteinizing hormone (LH) uye follicle-stimulating hormone (FSH), abarelix zvinobudirira kuderedza kugadzirwa kwe testosterone kubva kumachende. ngationgororei zviratidzo zvekurapa, maitiro echiito, uye mashandisiro eabarelix.
Abarelix inoratidzirwa kurapwa kwepalliative yevarwere vane zviratidzo vane advanced prostate cancer vanosangana nemaitiro chaiwo. Inokurudzirwa kuvarwere vasina kukodzera kukwikwidza ku luteinizing hormone-releasing hormone agonists, kuramba kuvhiyiwa castration, uye vane zvimwe zvinokonzera ngozi zvakadai sekugona kukuvadza kwetsinga nekuda kwemetastasis, ureteral kana bladder orifice obstruction inokonzerwa nekukukurwa kwenharaunda kana metastasis, kana kurwadziwa kwakanyanya kwemapfupa emapfupa kunoda kuenderera mberi nekurwadziwa kwenarcotic.
Seanobaiwa jekiseni gonadotropin-inoburitsa mahormone antagonist (GnRH antagonist), abarelix inoita basa rakakosha mukudzikisa kugadzirwa kwe testosterone muvarwere vane symptomatic prostate cancer kana dzimwe nzira dzekurapa dzisingakwanisi. Iyo inodzivirira zvakananga secretion yeLH neFSH, iyo inozoderedza kuburitswa kwe testosterone kubva kumachende. Nekunyima testosterone masero egomarara reprostate, abarelix inobatsira mukutonga kwechirwere uye kudzikisira kwezviratidzo zvinoenderana.
Kushandiswa kweabarelix mukurapwa kwegomarara reprostate kunopa imwe yakakosha kune varwere vasingakwanise kuvhiyiwa kana kuramba kuvhiyiwa castration kana mamwe marapirwo ehomoni. Kugona kwayo kupikisa GnRH uye kudzvinyirira kugadzirwa kwe testosterone kunopa zororo rekuzorora uye kunobatsira kudzora kufambira mberi kwechirwere. Nekudzikisa mazinga e testosterone, abarelix inobatsira mukudzivirira kukura uye kuwanda kwemasero egomarara reprostate, nekudaro ichipa zororo rechiratidzo nekuvandudza hupenyu hwemurwere.
Abarelix, ane simba gonadotropin-inoburitsa mahormone antagonist, inzira yakakosha yekurapa kune varwere vane symptomatic cancer yeprostate avo vasina kukodzera kukwikwidza ku luteinizing hormone-inoburitsa mahormone agonists kana kuvhiya castration. Nekudzivisa zvakananga LH neFSH secretion, abarelix inonyatso kuderedza kugadzirwa kwe testosterone, iyo yakakosha pakukura nekufambira mberi kwekenza yeprostate. Kushandiswa kwaro kunopa zororo rekuzorora uye kunobatsira kubata chirwere muvarwere vane mashoma ekurapa sarudzo. Abarelix, inotengeswa sePlenaxis, inoshanda sechishandiso chakakosha mukurwisa cancer yeprostate yakakwira, ichibatsira mukuvandudza mhedzisiro yemurwere uye kuwedzera hupenyu hwehupenyu.
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Tsanangudzo
