Arecoline hydrobromide Therapeutic Potential muCentral nervous system

Reference Mutengo: USD15-20/g

Product Name Arecoline
CAS Nha. 300-08-3
MF C8H14BrNO2
MW 236.109
EINECS 206-087-3
Acidity coefficient (pka) 6.84(pa25℃)
Melting point 171-175°C

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Tsanangudzo Yakadzama

Arecoline, iyo inonyanya kushanda alkaloid inowanikwa muareca nut, yakawana kutariswa kwekwaniso yayo yekurapa mukugadzirisa dambudziko repfungwa uye kuderedza zvirwere zvemudumbu. Ichi chinyorwa chine chinangwa chekupa pfupiso yakarongeka yemaitiro ekuita kwearecoline mune akasiyana masisitimu emuviri, anosanganisira oral cavity, central nervous system, cardiovascular system, uye digestive system. Pamusoro pezvo, hutano hunoita uye hunogona kuita chepfu mhedzisiro yearecoline ichaongororwa. Chekupedzisira, mashandisirwo earecoline mune hutano chikafu chekuwedzera, mishonga, uye zvizoro kugadzirira zvichakurukurwa.

Arecoline, nicotinic acid-based mild parasympathomimetic stimulant alkaloid, inonyanya kuita sechikamu cheagonist chemuscarinic acetylcholine receptors. Inoratidza parasympathetic mhedzisiro panzvimbo yekushungurudza nicotinic acetylcholine receptors senge nicotine. Arecoline inodzivisawo AMPK (adenosine monophosphate-activated protein kinase) kuburikidza nekugadzirwa kweiyo reactive oxygen marudzi (ROS) mumhando dzakasiyana-siyana dzemasero.

Mhedzisiro paMasisitimu Emuviri Akasiyana:

Nervous System: Arecoline inokurudzira kufara, inowedzera kudzidza nekuyeuka, uye inoderedza zviratidzo zvekuora mwoyo uye schizophrenia. Inogona zvakare kudzoreredza kurasikirwa kwendangariro kunokonzerwa ne scopolamine.

Cardiovascular System: Arecoline inoshanda sevasodilator, inowedzera plasma nitric oxide, eNos, uye mRNA kutaura, uye inoratidza anti-thrombosis uye anti-atherogenic madhara. Iyo zvakare inoderedza IL-8 uye zvimwe zvinhu.

Endocrine System: Arecoline inokurudzira masero eLeydig, zvichiita kuti kuwedzerwa mazinga e testosterone. Inoita kuti hypothalamic-pituitary-adrenal (HPA) axis, inokurudzira corticotropin-releasing hormone (CRH) kusunungurwa. Pamusoro pezvo, inobatsira kudzivirira kusashanda kwepancreatic beta masero kunokonzerwa nekudya kwakanyanya fructose.

Digestive System: Arecoline inokurudzira chirwere chekudya kuburikidza nekushandiswa kwemuscarinic receptors. Inowedzera kuputika kwegastric smooth muscle uye mitsetse yemhasuru ye duodenum, ileum, uye colon.

Hutano Mabasa uye Zvishandiso:

Analgesia uye Central Nervous System Effects: Arecoline hydrobromide inoratidza analgesic properties uye ine simba rekudzikamisa pane central nervous system.

Hutano Hweganda: Arecoline hydrobromide inosimudzira ganda metabolism uye inoratidza mukana wekurapa maronda eganda nezvimwe zvirwere zveganda.

Detoxification uye Diuretic Effects: Arecoline hydrobromide inobvisa kupisa, inobvisa muto, inobvisa kunyorova uye kuzvimba, uye ine diuretic properties.

Antibacterial uye Dissolving Stones: Arecoline hydrobromide inoratidza antibacterial zvinhu uye kugona kunyungudutsa matombo.

Kusimbisa Mutsipa Weropa uye Kutenderera Kweropa: Arecoline hydrobromide inobatsira kusimbisa midziyo yeropa uye kukurudzira kutenderera kweropa.

Applications:

Hutano Chikafu Chekuwedzera: Arecoline inogona kushandiswa sechinhu chinongedzo mune hutano chikafu chekuwedzera chakanangana neakananga mabasa ehutano, akadai sekuvandudza kwekuziva kana hutano hweganda.

Pharmaceuticals: Arecoline inogona kunge iine maitiro ekushandisa mumishonga, kunyanya mukurapa kwepfungwa dzepfungwa kana se antihelmintic drug.

Cosmetic Kugadzirira: Arecoline's ganda metabolism kukurudzira uye inogona kuporesa maronda zvivakwa zvinoita kuti ive mukwikwidzi wekugadzirira zvizorwa, kunyanya izvo zvinonangana nemaronda eganda kana zvimwe zvine chekuita neganda.

Arecoline, iyo inoshanda alkaloid inowanikwa muareca nut, inoratidza akasiyana siyana ekurapa uye ine maapplication mune akasiyana masisitimu emuviri. Nzira dzayo dzekuita dzinonyanya kupindirana kuburikidza nemuscarinic receptors uye inoratidza parasympathetic madhara. Kunyange zvazvo arecoline ichiratidza chivimbiso mukugadzirisa mamwe mamiriro ehutano, zvakakosha kufunga nezvezvinogona kuitika zvinokuvadza uye carcinogenic properties inobatanidza nekushandiswa kwayo.Bata nesu kana uchida.

Tsanangudzo