Kuberekwa nguva isati yakwana kunounza njodzi huru nemitoro kuvose vari vaviri mhuri nenzanga yose. Nekuda kweizvozvo, kudzivirira uye kurapwa kwekuzvarwa nguva isati yakwana ndiko kwakakosha zvakanyanya. Matocolytics, akadai seatosiban, anoita basa rakakosha mukunonotsa kuzvara nguva isati yakwana uye kudzivirira chibereko. Atosiban, cyclic nonapeptide uye oxytocin analogue, inoita seanokwikwidza anopikisa oxytocin receptors muchibereko, decidua, uye fetus membranes. Nekudzivisa kuputika kwechibereko, atosiban yakabuda sechinhu chinokosha chekliniki mukurapa kuberekwa nguva isati yakwana.
Atosiban, seyakasanganiswa oxytocin uye vasopressin V1A receptor antagonist, inopa yakasarudzika nzira yekudzivisa uterine contractions. Kufanana kwechimiro pakati peoxytocin receptor uye vasopressin V1A receptor inoda kuvharwa panguva imwe chete yenzira mbiri dzekugamuchira kuti zvinyatso kuvharidzira kuputika kwechibereko. Kusiyana nemamwe ma tocolytics akadai se beta-agonists, calcium channel blockers, uye prostaglandin synthase inhibitors, atosiban's dual receptor antagonism inobvumira kuvharidzirwa kwakanyatsonaka kwehutachiwana hwehutachiwana. Oxytocin, kunze kwekusimudzira uterine contractions, inokurudzirawo kugadzirwa uye kusunungurwa kwePGF2α, iyo inowedzera kuwedzera uterine smooth muscle contraction. Atosiban's high affinity ye oxytocin uye vasopressin V1A receptors inosungirirana nemakwikwi kune aya mareceptor, ichivharira zvinobudirira nzira dzekuita dze oxytocin uye vasopressin. Iyi nzira inotungamirira kukuderedza kukanganiswa kwechibereko.
Imwe yemabhenefiti akakosha eatosiban ishoma mhedzisiro. Nepo tachycardia yakapfava, kusimba kwechipfuva, dzungu, kutemwa nemusoro, kusvotwa, uye dyspnea zvakashumwa, mhedzisiro iyi kazhinji haidi kurapwa kwakakosha, uye mushonga hauwanzo kumiswa nekuda kwemhedzisiro. Uyezve, atosiban ine hafu yenguva pfupi yeplasma, inoderedza kuunganidza kwayo mu "fetus circulation" uye kuderedza dambudziko remigumisiro yakaipa pa "fetus".Miedzo yekiriniki yakaratidza kushanda kweatosiban mukuwedzera kubata pamuviri kuvakadzi vane mavhiki anopfuura makumi maviri nemasere ekuberekwa. Mumuyedzo wakawanda, wakapetwa kaviri-mapofu, wakadzorwa neplacebo, kurapwa kweatosiban kwakakonzera kureba kwepamuviri kusvika kumazuva manomwe. Kuenzanisa miedzo yekiriniki yakaratidzawo atosiban kuva neinofananidzwa tocolytic chiito kune ritodrine ichibvumirwa zviri nani, kunyanya maererano nemigumisiro yemwoyo yaamai. Izvi zvakawanikwa zvinosimbisa kugona kweatosiban sechinhu chinoshanda uye chakanyatso kutenderwa tocolytic mumiriri.
Atosiban, seanokwikwidza vasopressin/oxytocin receptor antagonist, anoita basa rakakosha mukudzivirira kuzvara nguva isati yakwana. Kugona kwayo kuvharidzira kubvongodzwa kwechibereko kuburikidza neaviri receptor antagonism inoita kuti ive chishandiso chakakosha chekunonoka kubereka nguva isati yasvika. Izvo zvidiki mhedzisiro, pfupi plasma hafu yehupenyu, uye kushomeka kuunganidzwa mukutenderera kwe fetal kunowedzera kuwedzera kwayo kuchengetedza chimiro. Pamusoro pezvo, kugona kweatosiban mukuvandudza mhedzisiro yekuzvitakura kune varwere vanodzokororwa kutadza kuisirwa pasi peIVF-ET inoratidza kugona kwayo uye kugona mukurapa kwekubereka. Kuenderera mberi nekutsvagisa uye kushandiswa kwekiriniki kweatosiban kunogona kubatsira zvakanyanya kudzikisira mutoro wekuzvarwa nguva isati yakwana kumhuri nenharaunda.
