0102030405
Bivalirudin: A Reversible Thrombin Inhibitor yeInoshanda Anticoagulation
Tsanangudzo Yakadzama
Bivalirudin inogadzirwa makumi maviri-yakasarira peptide inoshanda seyakagadziriswa inhibitor yethrombin, enzyme yakakosha inobatanidzwa mukuumbwa kweropa. Nekusunga kunzvimbo inoshanda yethrombin, bivalirudin inodzivirira kutendeuka kwefibrinogen kuita fibrin, danho rakakosha mukuumbwa kwethrombus. Inotungamirirwa intravenously, bivalirudin inobata basa rinokosha mukurapa kweanticoagulation. Nekudaro, kunyatsotarisisa hematocrit, activated partial thromboplastin time (aPTT), international normalized ratio (INR), uye blood pressure inodiwa nekuda kwekugona kwayo kukonzera kusamira kweropa.
Bivalirudin inoratidza inhibitory mhedzisiro pane zvese zvinonyungudika uye thrombus-yakasungwa thrombin in vitro. Zvakakosha, iyi inhibitory effect inoramba isina kukanganiswa neplatelet-yakaburitswa zvigadzirwa. Nemaitiro anoenderana nedosi, bivalirudin inogona kuwedzera plasma aPTT, nguva yethrombin, uye nguva yeprothrombin muzvidzidzo zvevanhu zvakajairika. Aya maitiro anoita kuti zvive zvakanyanya kukodzera kushandiswa mu percutaneous coronary intervention (PCI) kune varwere vane angina isina kugadzikana.
Cardioembolic sitiroko, inozivikanwawo se cardiac stroke, inoitika apo emboli inobva pamwoyo uye aortic arch inofamba nemuropa, zvichitungamira kune cerebral arterial embolism uye kunotevera kusashanda kwecerebral. Mwoyo wemwoyo, uchienzaniswa nekurohwa kweischemic yemamwe etiologies, inowanzova yakaoma zvikuru maererano nezvikonzero zvinokonzera, zvakanyanya kuoma maererano nekutaura, kuva nehutachiona husina kunaka, uye huwandu hwekudzoka zvakare. Inenge 70% yekurohwa kwese kunobva pamoyo kunonzi kune atrial fibrillation (AF). Kurapa kweAnticoagulant kwakakodzera kumamiriro emurwere kwakakosha pakudzivirira kwechipiri kweAF-inoenderana nechirwere chemoyo.
Kana uchifunga nezve kushandiswa kwebivalirudin, zvakakosha kuti urambe uchifunga nezve zvinodikanwa zvekutarisisa kuitira kuti murwere achengetedzeke. Shanduko muhematocrit, aPTT, INR, uye BP inofanirwa kunyatsocherechedzwa kuti ione chero zvingangove zvine chekuita nekudzika kweropa. Kugara kwekutarisa kunobvumira vashandi vehutano kuti vagadzirise dosi uye vaone kuti murwere ari kugamuchira nhanho yakakodzera yeanticoagulation.
Bivalirudin, seinodzoreredzwa thrombin inhibitor, inoita basa rakakosha mukurapa kweanticoagulation. Nekudzivisa thrombin, inodzivirira kuumbwa kwefibrin uye kunotevera kuumbwa kwekuvhara. Izvi zvinoita kuti ive sarudzo inoshanda yekushandiswa mupercutaneous coronary intervention, kunyanya kune varwere vane angina isina kugadzikana.
Kana iwe uine chero zvinoenderana nezvinodiwa zveBivalirudin, ndapota usazeza kutibata nemutengo uri nani.
Kana iwe uine chero zvinoenderana nezvinodiwa zveBivalirudin, ndapota usazeza kutibata nemutengo uri nani.
Tsanangudzo
