0102030405
CARBETOCIN Postpartum Hemorrhage powder
Tsanangudzo Yakadzama
Nhanganyaya:
Carbetocin, yakagadzirwa kwenguva refu-inobata oxytocin analog, inoratidza zvimiro zvakafanana nezvinowanzoitika oxytocin. Inoita senge agonist, inosunga kune uterine yakatsetseka tsandanyama receptors uye ichikonzera rhythmic contractions yechibereko. Carbetocin inonyanya kushanda muchibereko chine pamuviri uye chichangobva kusununguka, sezvo oxytocin receptor yemukati inokwira zvakanyanya munguva idzi. Muchinyorwa chino, tichaongorora kiriniki uye pharmacological zvimiro zvecarbetocin, tichitarisa pakushandiswa kwayo mukudzora kubuda kwepashure uye kudzivirira kuputika kwechibereko mushure mechikamu checesarean.
Postpartum Hemorrhage Control:
Carbetocin mushonga unokosha unoshandiswa kugadzirisa kubuda kweropa mushure mekusununguka, izvo zvinoreva kubuda ropa kwakanyanya mushure mekusununguka. Nokuita kuti uterine contractions iite, carbetocin inobatsira kudzorera uterine tone, kuderedza ngozi yekubuda ropa zvakanyanya. Kubudirira kwaro kunowanikwa mukukwanisa kwayo kuwedzera kuwanda uye tension ye uterine contractions, kudzivirira kana kuderedza kubuda kweropa mushure mekusununguka.
Carbetocin inowanzoshandiswa mushure mekusarudza epidural kana spinal anesthesia panguva yecesarean section maitiro ekudzivirira uterine contraction uye inotevera postpartum hemorrhage. Iyi tsika inovimbisa kuti uterine tsandanyama dzinoramba dzakabatanidzwa, kuderedza mukana wekubuda ropa zvakanyanya. Zvisinei, kushandiswa kwecarbetocin muzvikamu zvekukurumidzira cesarean, classic cesarean section, uye pasi pemamwe marudzi eanesthesia kana pamberi pemamiriro ezvinhu ehutano chaiwo haana kunyatsodzidza. Nokudaro, kuchenjerera kunofanira kushandiswa paunenge uchifunga nezvekutonga kwecarbetocin mumamiriro ezvinhu aya.
Mechanism of Action:
Carbetocin inoshanda seoxytocic, antihemorrhagic, uye uterotonic drug, kunyanya yakanangana neperipheral nervous system. Inoita seanopikisa paperipheral oxytocin receptors, kunyanya mumyometrium (uterine muscle). Aya maoxytocin receptors ari G protein-akabatanidzwa, uye kushandiswa kwawo kunosanganisira nhume yechipiri uye kugadzirwa kweinositol phosphates. Carbetocin inotevedzera iyi nzira, inosunga zvisina kusarudzwa pane extracellular N-terminus uye zvishwe E2 uye E3 yeoxytocin receptor. Kunyange zvazvo carbetocin uye oxytocin zvine hukama hwakafanana kune zvinogamuchira, carbetocin biological effect inenge 50% iyo ye endogenous kana exogenous oxytocin. Zvinonzwisisika, carbetocin ine mhedzisiro inogara kwenguva refu kupfuura oxytocin, inoda chete dosi rimwe chete. Iyo inodzivisawo kusunungurwa kwe endogenous oxytocin, kukanganisa uterine feedback loop ne hypothalamus uye kuderedza zvose zviri pakati uye peripheral oxytocin kusunungurwa. Carbetocin inogona kutorwa seyakarerekera agonist yeoxytocin receptor.
Panguva yekuzvitakura, kuumbwa kweoxytocin receptors muchibereko kunowedzera zvakanyanya, kusvika pakakwirira panguva yekusununguka uye yekusununguka. Nekuda kweizvozvo, kupihwa kwecarbetocin kana imwe oxytocin analog panguva kana pakarepo mushure mekuzvarwa kunowedzera uterotonic uye contractile mhedzisiro. Nekudaro, carbetocin haina mhedzisiro pachibereko chisina pamuviri chine yakaderera oxytocin receptor kutaura. Uyezve, carbetocin inobatsira mukukora kweropa, zvichiwedzera kuderedza njodzi yekubuda ropa kwepashure.
Chengetedzo uye Miganhu:
Zvakakosha kucherechedza kuti carbetocin haifaniri kushandiswa pakupinza basa kana kuwedzera, sezvo inogona kutungamirira kumwoyo kana kufema kunetseka mune zvose amai uye mucheche.
Mhedziso:
Carbetocin, inogadzirwa oxytocin analog, inopa nzira yakakosha yekugadzirisa kubuda kweropa mushure mekusununguka nekudzivirira kubuda ropa kwakanyanya mushure mechikamu chekuvhiya. Nekutevedzera maitiro echisikigo oxytocin, carbetocin induces uterine contractions uye inosimudzira uterine tone. Nekudaro, kushandiswa kwayo kunofanirwa kunyatsotariswa mune chaiwo mamiriro, uye vashandi vehutano vanofanirwa kungwarira pakubata carbetocin.
Rangarira kutibata nesu Carbetocin Factory yakananga mutengo wekupa.
Tsanangudzo
