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Cisplatin Powder Cisplatin Purity 99% Cisplatin Pharmaceutical
Tsanangudzo Yakadzama
Cisplatin, inozivikanwawo nezita rayo rekutengesa Platinol, mushonga wechemotherapy unoshandiswa kurapa marudzi akasiyana egomarara.
Kutaridzika Tembiricha kuti ichengetedze kugadzikana kwayo. Kana yakachengetedzwa zvakanaka, cisplatin inochengetedza makemikari ayo uye simba. gare gare yakaferefetwa pamusoro pezvinogona kuita anticancer properties uye yakaonekwa kuti inoshanda mukurapa zvirwere zvakasiyana-siyana.
Basa uye Mashandisirwo: Cisplatin inorondedzerwa seplatinum-based chemotherapy drug uye inhengo yemhuri yealkylating agents.Inoshandisa maitiro ayo ekurwisa kenza kuburikidza nekugadzira zvisungo zvakabatanidzwa neDNA, zvichiita kuti kuvhiringidzwe kwekushanda kwemasero uye pakupedzisira kukonzera kufa kwesero. ,cisplatin inosunga kune zvigadziko zve purine muDNA, ichiita intrastrand uye interstrand crosslinks.Izvi zvinokanganisa zvinokanganisa kudzokorora kweDNA uye kunyora, zvichiita kuti kuvharwa kwekuwedzera kwesero uye kuiswa kweapoptosis mumasero ekenza.Cisplatin inoshandiswa zvakanyanya mukurapa kwakasiyana-siyana kwakasiyana-siyana. mhando dzegomarara, kusanganisira testicular, ovarian, dundira, musoro nemutsipa, wemapapu, uye kenza yemuchibereko.
Inowanzova chikamu chemusanganiswa wechemotherapy regimens uye inoitwa intravenously munzvimbo yekiriniki pasi pekutariswa kwevashandi vehutano.Kusanganiswa kwe cisplatin nemamwe chemotherapeutic agents, senge etoposide, bleomycin, uye fluorouracil, kwakaratidza maitiro ekubatana mukurapa kwezvimwe. Pamusoro pebasa rayo rekutanga mukurwara kwebundu rakasimba, cisplatin inoshandiswawo mukurapa mamota ejemisi cell, ese ari mumiririri mumwe chete uye pamwe chete nemamwe chemotherapy mishonga. kunyanya kana ichishandiswa pamwe chete nemamwe platinum-based agents akadai etoposide uye bleomycin. Uyezve, cisplatin yakadzidzwa kuitira kushandiswa kwayo mune dzimwe mhando dzekenza, kusanganisira gurokuro, gastric, uye pancreatic cancers.
Tsvagiridzo inoenderera mberi nekuongorora kushanda kwayo mukubatana neinoveli yakanangwa marapirwo uye immunotherapies kuwedzera mhedzisiro yekurapa uye kuderedza kusimukira kwekudzivirira. Kunze kwekurapwa kwegomarara, cisplatin yakaongororwawo nekuda kwekushandisa kwayo mulocalized hyperthermia therapy, iyo inosanganisira kupisa nzvimbo dzakati dze Muviri kuuraya maseru egomarara kana kuita kuti anyanye kunzwa kune mamwe marapiro.Muchirevo chechinyorwa chino, cisplatin inoshandiswa pamwe chete nekupisa kuti iwedzere cytotoxic mhedzisiro yayo mukati mebundu microenvironment.
Muchidimbu, cisplatin inogadzirwa neplatinum-based chemotherapy drug iyo inoshandisa anticancer mhedzisiro nekugadzira DNA crosslinks uye kukonzeresa kufa kwesero mumasero egomarara. gomarara remuchibereko, netsvakiridzo inoenderera mberi ichiongorora kugona kwayo mune dzimwe hutsinye.Uyezve, cisplatin ine zvingangoshandiswa mu hyperthermia therapy uye inoramba iri chinhu chakakosha chemusanganiswa wechemotherapy regimens.
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