Tsanangudzo Yakadzama
Clomiphene, mushonga unotenderwa neFDA unonyanya kushandiswa kumatambudziko ekuzvara kwevakadzi, wagara uchinzi hauna kukodzera varume. Nekudaro, varapi vekucheka-kumucheto vakawana zvinogona kushandiswa kweclomiphene muvarume vane yakaderera urume kuverenga kunokonzerwa nemajini kana kushandisa steroid. Pamusoro pezvo, vagadziri vemuviri vechirume vatanga kushandisa clomiphene semushonga wekuchengetedza testosterone kuti uwedzere kukura kwemhasuru. Isu tiri kupa muchidimbu nezve clomiphene's mechanism of action, maitiro ayo pamazinga ehomoni, uye zvingangobatsira uye njodzi kune varume.
Clomiphene inozivikanwa kuti inokanganisa estrogen axis mumuviri, kunyange zvazvo maitiro ayo chaiwo echiito anoramba asinganzwisisiki. Inopindirana neestrogen receptors mumhando dzakasiyana-siyana, kusanganisira hypothalamus, pituitary gland, ovaries, endometrium, vagina, cervix, adrenal glands, peripheral adipose tissue, chiropa, uye testes. Muvakadzi, clomiphene inonyanya kushanda pa hypothalamus uye pituitary gland, inokurudzira kubudiswa kwegonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), uye luteinizing hormone (LH). Kukurudzira uku kunosimudzira ovulation. Muvarume, clomiphene inoshandawo pa hypothalamus uye pituitary gland, zvichiita kuti kuwedzere kubudiswa kwe testosterone uye urume.
Kusiyana nekutenda kwakakurumbira, clomiphene haideredze mazinga eesrogen mumuviri. Muchokwadi, inogona kukurudzira secretion yeestrogen kusvika pamwero wakati muvarume. Zvakakosha kune vanhu vanoshandisa clomiphene, kunyanya varume vanoita muviri, kutarisa zvose testosterone uye estradiol mazinga kuti vadzivise zvinogona kuitika zvakadai segynecomastia (kuwedzerwa kwezamu remurume).
Varume vanovaka muviri vanowanzo shandisa clomiphene sechinhu chinowedzera kune yavo steroid cycle. Zvisinei, zvakakosha kuziva kuti clomiphene haina kurongerwa semishonga inosimbisa muviri uye haina androgenic migumisiro. Kushandiswa kwenguva refu kwe clomiphene muvarume kwave kwakabatanidzwa ne macromastia (mazamu akakura) uye testicular tumors, kunyange zvazvo chirevo chechikonzero chinokonzera pakati pe clomiphene nemigumisiro iyi haisati yasimbiswa.
Kunyange zvazvo clomiphene iri kuwedzera kushandiswa nevarume vanovaka muviri nevatambi, kushanda kwayo muvarume kunoramba kusinganyatsozivikanwi nekuda kwezvidzidzo zvishoma. Zvakakosha kuchenjerera kana uchifunga nezvekushandisa clomiphene, kunyanya kana pasina humbowo hunogutsa. Uyezve, zvinokurudzirwa kubvunza nyanzvi yehutano usati waisa clomiphene mu steroid regimen.
Zvinokurudzirwa:
murume
Clomiphene inoshandiswa mu pct, pamwero we 50-100 mg zuva nezuva kwemazuva 30 kuti udzorere kugadzirwa kwe testosterone yakasikwa kumazinga akaenzana. Kushandiswa uku kunowanzoonekwa sekwakanyatsokodzera sechikamu chechirongwa chekudzoreredza chemashure (ona PCT Kurapa)
vatambi vechikadzi
Clomid dzimwe nguva inoshandiswa kuderedza estrogen isati yakwikwidzana mumakwikwi ekuvaka muviri. Mune zvimwe zviitiko, izvi zvinogona kubatsira kurasikirwa kwemafuta uye kukurudzira kukura kwemhasuru, kunyanya munzvimbo dzinonetsa dzevakadzi dzakadai semagaro uye zvidya. Zvisinei, mushonga uyu unowanzova nemigumisiro inotambudza muvakadzi vasati vasvika uye naizvozvo haisi kudiwa zvikuru pakati peboka iri.
Clomiphene, inonyanya kushandiswa kumatambudziko ekubereka kwevakadzi, yakawana kutariswa kwekushandisa kwayo muvarume vane huwandu hwembeu yakaderera uye semushonga wekuchengetedza testosterone kune vanovaka muviri. Maitiro ayo ekuita anosanganisira kukurudzira secretion yegonadotropins, iyo inosimudzira ovulation muvakadzi uye kugadzirwa kwe testosterone muvarume. Zvisinei, kubudirira uye kuchengeteka kwe clomiphene muvarume kunoda kumwe kutsvakurudza.
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Tsanangudzo
