0102030405
Memantine HCl 99% Purity kurapa chirwere cheAlzheimer Factory Supply
Tsanangudzo Yakadzama
Memantine hydrochloride, yakagadziridzwa naMerz kuGermany, mushonga unozivikanwa pakutanga wakagadzirirwa kurapwa kwedementia. Inoita seasina kukwikwidza N-methyl-D-aspartate (NMDA) receptor antagonist, ichivharira NMDA receptors uye kuderedza glutamate-induced hyperexcitability. Iyi nzira ine chinangwa chekuvandudza kugona kwekuziva, kudzivirira apoptosis, uye kuwedzera ndangariro. Pethidine hydrochloride yakagamuchirwa neEuropean Committee for Patented Medicinal Products (CPMP) yekurapa kwechirwere cheAlzheimer chepakati kusvika kune chakanyanya muna 2002. Zvimwe zvidzidzo zvakaratidzawo kushanda kwayo kune varwere vane chirwere cheAlzheimer chinyoro kusvika pakati.
Memantine hydrochloride, iyo inoshandiswa mu pethidine hydrochloride, ine mwero-inobatana, isina kukwikwidza NMDA receptor antagonist. Kunyange zvazvo kushandiswa kwayo kwekutanga kuri kurapwa kwechirwere cheAlzheimer, chakave chakadzidzwa zvakanyanya uye chakashandiswa kune dzimwe nzvimbo dzepakati dzetsinga dzakadai sepfari, migraines, uye mamiriro epfungwa anosanganisira bipolar disorder uye schizophrenia. Dementia inoramba iri iyo yekutanga kutariswa kwekushandiswa kwememantine, uye yakaratidza mabhenefiti akasiyana muchirwere cheAlzheimer, vascular dementia, uye dementia nemitumbi yaLewy. Haingonatsiridze basa rekuziva chete asiwo inogadzirisa zviratidzo zvehunhu uye zvepfungwa zvedementia (BPSD), zvakaita sekufungidzira, kunyengera, kusagadzikana, hasha, uye kushatirwa.
Pamusoro pekuita kwayo padementia, memantine yakaongororwa nekuda kwemhedzisiro yayo pane mamwe maoresheni etsinga. Varwere vane pfari vanowanzoona kushomeka kwenjere, uye memantine yakaratidza kugona mukuderedza kushomeka uku. Uyezve, hosha yeAlzheimer pachayo injodzi yekubatwa nepfari, uye vanhu vane chirwere ichi vari panjodzi huru yekubatwa nepfari kana vachienzaniswa nevasina Alzheimer's. Nekudzivisa neuroexcitotoxicity yakabatana neNMDA receptor hyperactivation, memantine inogona kuva nemigumisiro ye antiepileptic.
Uyezve, memantine yakadzidzwa mukati meiyo yakazara-brain radiation therapy (WBRT), traumatic brain injury (TBI), uye sitiroko. WBRT inogona kutungamira mukukanganisa kwekuziva, uye memantine yakaratidzwa kunonoka kutanga kwayo uye kugadzirisa kugona kwekuziva. Iyo yakasiyana-siyana yemishonga yemishonga ye memantine yakaita kuti iongorore mune zvakasiyana-siyana zvehutano hwehutano.
Zvidzidzo zvenguva pfupi yapfuura zvakatokurudzira kushandiswa kwememantine mukudzikamisa neurotoxic mhedzisiro yeCCIDID-19 uye kuvharidzira kudzokororwa kwehutachiona, zvichiratidza kukosha kwayo kwekiriniki.
Memantine hydrochloride, kunyanya iyo inoshanda sememantine hydrochloride, yakaratidza kushanda mukurapa dementia, kunyanya chirwere cheAlzheimer. Iyo yakasarudzika nzira seNMDA receptor antagonist inobvumira kuvandudzwa mukuziva basa uye manejimendi ehunhu uye hwepfungwa zviratidzo zvine chekuita nedementia. Uyezve, memantine inoratidza kuvimbiswa mune zvimwe zvirwere zvetsinga zvakadai sepfari, migraines, uye post-radiation cognitive impairment. Tsvagiridzo inoenderera mberi ichitsvaga iyo inogona kuve yekiriniki kukosha kwememantine mumamiriro akasiyana-siyana eurological.
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