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Rosuvastatin antilipemic agent Rosuvastatin kurapa dyslipidemia
Rosuvastatin antilipemic agent Rosuvastatin kurapa dyslipidemia
Rosuvastatin antilipemic agent Rosuvastatin kurapa dyslipidemia
Rosuvastatin antilipemic agent Rosuvastatin kurapa dyslipidemia

Rosuvastatin antilipemic agent Rosuvastatin kurapa dyslipidemia

Reference mutengo: USD 5-10/g

  • Product Name Rosuvastatin
  • CAS Nha. 287714-41-4
  • MF C22H28FN3O6S
  • MW 481.54
  • EINECS 689-191-5
  • Density 1.368±0.06 g/cm3(Zvakafanotaurwa)
  • Melting point 161.9 °C
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Tsanangudzo Yakadzama

Rosuvastatin inowanzoshandiswa mishonga inoshandiswa kurapa hypercholesterolemia uye mamiriro ane hukama. Mushonga uyu, unozivikanwa sema statins, unoshandiswa pamwe chete nekurovedza muviri, kutonga kwekudya, uye kurasikirwa nehuremu kuvandudza mazinga echolesterol uye kudzivirira chirwere chemoyo. Ichi chinyorwa chichaongorora maitiro echiito uye kukiriniki kushandiswa kwerosuvastatin, pamwe nemhedzisiro yayo pane lipid abnormalities uye hutano hwemoyo wese.

Rosuvastatin, inorongedzerwa seantilipemic agent uye nhengo ye statin class yemishonga, inonyanya kushandiswa kurapa dyslipidemia, kusanganisira yakakwira cholesterol. Inoshanda nekuvhara enzyme inobatanidzwa mukugadzirwa kwecholesterol mumuviri, zvichiita kuti kuderedzwa kwehuwandu hwecholesterol uye triglycerides, panguva imwe chete ichiwedzera mazinga e-high-density lipoprotein (HDL) cholesterol, inowanzonzi "yakanaka" cholesterol. Rosuvastatin inonyanya kushanda kana yakasanganiswa nekudya kune hutano uye chirongwa chekurovedza muviri. Uyezve, inoshandiswa kurapa vanhu vane zvimwe zvakagarwa nhaka cholesterol. Kushandiswa kwekiriniki yerosuvastatin kunosanganisira kurapwa kwekutanga hypercholesterolemia, mhuri hypercholesterolemia, uye lipid kusagadzikana kunokonzerwa nezvimwe zvinhu.


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Rosuvastatin inhibits enzyme hydroxymethylglutaryl-CoA reductase muchiropa, iyo inoderedza cholesterol synthesis uye inoderedza serum cholesterol uye triglyceride mazinga. Uyezve, Rosuvastatin inowedzera kutora kwechiropa uye kuparara kweyakaderera-density lipoprotein cholesterol (LDL-C), uyewo ichikwidza mazinga e-high-density lipoprotein cholesterol (HDL-C). Pamusoro peiyo lipid-kudzikisa mhedzisiro, Rosuvastatin yakaratidza kuve ine anti-atherosclerotic, anti-inflammatory, antioxidant, plaque stabilizing, uye yakagadziridzwa endothelial function properties.

Rosuvastatin inogadzirwa kuburikidza nekuvirisa kweAspergillus terreus kana kuburikidza nemakemikari synthesis. Kana yangopinzwa, inogadziriswa zvakanyanya muchiropa uye inoshandurwa kuita akasiyana metabolites, kusanganisira inoshanda metabolites inodzivirira HMG-CoA reductase. Mushonga wacho nemametabolites ayo anonyanya kubudiswa mutsvina, ane chidimbu chiduku chinobudiswa muweti.


Nemakwikwi inhibiting HMG-CoA reductase, chiyero-chinomisa enzyme mucholesterol synthesis, lovastatin inoderedza endogenous cholesterol kugadzirwa uye inowedzera kutaura kweLDL receptors mumasero echiropa. Izvi zvinoguma nekuwedzera kucheneswa mwero weLDL cholesterol. Lovastatin inobatsirawo kuderedza serum triglyceride mazinga uye kuwedzera mazinga eHDL cholesterol, inobatsira mukudzivirira uye kurapwa kweatherosclerosis uye chirwere chemwoyo.

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Rosuvastatin mishonga yakakosha yekurapa hypercholesterolemia uye mamiriro ane hukama. Rosuvastatin inonyanya kuita nekuvhara cholesterol kugadzirwa uye kuvandudza cholesterol mazinga musanganiswa nemararamiro ekuchinja. Kune rumwe rutivi, inhibits cholesterol synthesis uye inowedzera kutora kwechiropa uye kuparara kweLDL cholesterol, zvichiita kuti cholesterol yakaderera uye triglyceride mazinga. Yakaratidza kushanda mukuvandudza lipid abnormalities uye hutano hwemoyo wese. Zvakakosha kuti titaurirane nesu kune mutungamiri wehutano hwehutano kuti aone kushandiswa kwakakodzera uye kuyerwa kwemishonga iyi zvichienderana nezvido zvemunhu uye nhoroondo yezvokurapa.

Tsanangudzo

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