Triptorelin, yakagadzirwa decapeptide uye analog yeakasikwa gonadotropin-inoburitsa mahormone (GnRH), yakawana kuzivikanwa kwakakosha munharaunda yekurapa. Inoshandiswa kune zviratidzo zvakasiyana-siyana, kusanganisira kurapwa kweendometriosis, fibroids, kenza yeprostate, precocious kuyaruka, uye kushaya mbereko. Triptorelin inoita nekutanga kukurudzira secretion yegonadotropins uye yozodzikisa gonadotropin-inoburitsa mahormone receptors, zvichikonzera kudzikiswa kwenguva refu kwekuburitswa kwegonadotropin.
Triptorelin inoratidza huwandu hwakawanda hwekurapa maitiro. Muvakadzi, inoshandiswa kugadzirisa endometriosis, uterine fibroids, uye kusabereka. Kuenderera mberi kweTriptorelin kutonga kunodzivirira kugadzirwa kweestradiol, zvichitungamira kudzvinyirirwa kwe ectopic endometrial tissue mu endometriosis. Pamusoro pezvo, zvidzidzo zvakaratidza kudzikiswa kwakanyanya muhukuru hweuterine fibroids, nevarwere vazhinji vachiona amenorrhea mushure memwedzi wekutanga wekurapwa. Nekushaya mbereko, triptorelin inhibits secretion yegonadotropins, kuvandudza mhando yefollicle kugadzirwa uye kuwedzera huwandu hwefollicles, nekudaro ichiwedzera mikana yekubudirira yakabatsirwa nzira dzekubereka senge in vitro fertilization.
Muvarume, triptorelin inowanzoshandiswa kurapa kenza yeprostate. Inoita nekutanga kuwedzera ropa luteinizing hormone (LH) uye follicle-stimulating hormone (FSH) mazinga, inoteverwa nekuderera kwemahomoni aya uye kuderera kunotevera kwemazinga e testosterone eropa. Uku kuderedzwa kwemazinga e testosterone kunobatsira mukurapa kenza yeprostate uye zviratidzo zvayo zvakabatana. Majekiseni eTriptorelin anga achishandawo mukurapa kwe precocious kuyaruka, inhibiting pituitary hypersecretion yegonadotropins uye normalizing hormone levels.
Maitiro ekuita kwe triptorelin anosanganisira zvese kudzvanywa kwegonadotropin secretion uye yakananga gonadotropic inhibition nekudzikisira peripheral GnRH receptors. Zvidzidzo zvemhuka uye zvevanhu zvakaratidza mhedzisiro yekusingaperi triptorelin kushandiswa pagonadotropin secretion, zvichitungamira kudzvinyirirwa kwe testicular uye ovarian basa. Kubudirira kweTriptorelin kunowedzera kuratidzwa nekuvandudzwa kwekiriniki muzviratidzo zvakaita se dysmenorrhea, kurwadziwa kusingaperi kwepelvic, uye kurwadziwa panguva yekusangana pabonde.
Isu tinopa akasiyana-siyana akagadziridzwa mhinduro kuti iwe usarudze kubva
Triptorelin jekiseni: 0.1 mg/1 ml.
Triptorelin yakawedzerwa-kusunungurwa jekiseni: 3.75 mg; 11.25 mg; 22.5 mg.
Triptorelin pamoate yejekiseni: 15 mg pabhodhoro (rine 1 bhodhoro re 2 ml solvent). Kana iwe uine zvimwe zvaunoda, iwe unogona zvakare kutibata uye isu tinokupa iwe nekukurumidza uye kwakaringana masevhisi ekugadzirisa.
Seyakasimba gonadotropin analog, Triptorelin inopa huwandu hwekurapa kwekushandisa kune vese varume nevakadzi. Kugona kwayo kudzora mazinga ehomoni uye inhibit gonadotropin secretion yakaratidza kushanda mukugadzirisa mamiriro akaita se endometriosis, uterine fibroids, kenza yeprostate, precocious kuyaruka, uye kushaya mbereko. Nekushanda kwayo kwekiriniki uye kushandiswa kwakasiyana-siyana, triptorelin inoramba ichibatsira zvakanyanya mumunda wemishonga yekubereka uye oncology.Kunzwisisa nzira dzekuita uye gadziriro dziripo dze triptorelin inobvumira vashandi vehutano kuti vagadzirise zvirongwa zvekurapa kune mumwe murwere zvinodiwa.
