0102030405
Vincristine Sulfate Powder Vincristine Purity Vincristine CAS 57-22-7
Tsanangudzo Yakadzama
Vincristine is white to off-white crystalline powder.Inoita isinganyunguriki mumvura, asi inonyungudika mune mamwe organic solvents.Mushonga wakachena haunhuhwi uye unowanzochengetwa munzvimbo yakaoma, ine rima pasi pemamiriro ekushisa anodzorwa kuti arambe akadzikama. Iri alkaloid inowanzoitika yakabva kuMadagascar periwinkle plant (Catharanthus roseus) .Maumbirwo ayo emakemikari akafanana nevinblastine,anomwe vinca alkaloid.Vincristine inoshandiswa zvakanyanya mukurapa marudzi akasiyana-siyana ekenza,kusanganisira leukemia,lymphoma, nemamota akasimba. .
Vincristine inonzi microtubule inhibitor inovhiringidza kuumbwa kwe microtubules, iyo inokosha zvikamu zve cytoskeleton yesero. Nekusunga kune tubulin, inodzivirira kuungana kwema microtubules, zvichiita kuti mitotic kusungwa uye kufa kwesero mukuparadzanisa masero. Vincristine inonyanya kushanda pakurwisa nekukurumidza kupatsanura masero ekenza.Kushandiswa kwekiriniki ye vincristine kunosanganisira kurapwa kwezvirwere zvakasiyana-siyana zvakadai seacute lymphoblastic leukemia(ALL),Hodgkin's and non-Hodgkin's lymphomas,vana uye vakuru vakasimba mapundu,neuroblastoma,uye rhabdomyosarcoma.Vincristine inowanzoshandiswa. mukubatana nemamwe machemotherapeutic agents sechikamu chemishonga yakawanda yemishonga, pamwe chete inozivikanwa semusanganiswa chemotherapy.
Pamusoro pekushandiswa kwayo kwekutanga mukurapa cancer, vincristine yakaratidzawo kushanda mukutonga kwemamwe mamiriro asiri eoncological. Inoshandiswa mukurapa idiopathic thrombocytopenic purpura (ITP), chirwere che autoimmune chinoratidzwa nekuderera kweplatelet count. ,vincristine yakaratidza kugona mukutonga kwemamiriro akasiyana-siyana etsinga, kusanganisira chisingaperi chinoputira demyelinating polyneuropathy (CIDP) uye vana autoimmune neuropsychiatric disorders inobatanidza ne streptococcal infections (PANDAS).
Uyezve, vincristine's anti-angiogenic properties yakatungamirira kuongororo yekushandiswa kwayo mukurapa kwezvirwere zvakasiyana-siyana zvinopararira, kusanganisira chirwere cheshuga retinopathy uye zera remacular degeneration.Zvisinei, vincristine inonyanya kuzivikanwa nebasa rayo mukurapa kenza, uye kushandiswa kwayo mukurapa kenza. mamwe mamiriro ezvehutano anoonekwa seasiri-label uye anoda kunyatsoongororwa kwengozi dzinogona kuitika uye zvinobatsira.Muchidimbu, vincristine, yakabva kuMadagascar periwinkle plant, inokosha inorwisa kenza inovhiringidza kuumbwa kwe microtubule uye inokonzera kufa kwesero mukuparadzanisa masero. makiriniki akasiyana-siyana anosanganisira kurapwa kweleukemia, lymphoma, mamota akasimba, uye mamwe mamiriro asiri e-oncological.Kunyange zvazvo kushandiswa kwayo kwekutanga kuri mukurapa kenza, tsvakurudzo inoenderera mberi ichitsvaga kukwanisa kwayo mumamiriro ehutano akasiyana.
Tsanangudzo
