Abaloparatide, oo lagu iibiyo magaca sumadda Tymlos, waa analoog synthetic ee borotiinka hormoonka parathyroid (PTHrP). Waa wakiilka anabolic ee loo isticmaalo daawaynta lafo-beelka, xaalad lagu garto lafaha daciifka ah iyo khatarta sii kordheysa ee jabka. Abaloparatide waxaa lagu tilmaamaa haweenka postmenopausal iyo ragga qaba lafo-jileeca khatarta sare leh ee jabka, iyo sidoo kale kuwa ku guuldareystay ama u dulqaadan karin daaweynta lafaha kale ee la heli karo. Adoo si xushmad leh u hawlgeliya hormoonka parathyroid 1 reseptor (PTH1R), abaloparatide waxay kor u qaadaa koritaanka lafaha waxayna kordhisaa cufnaanta lafaha.
Abaloparatide waa 34 amino acid analoog synthetic ah oo PTHrP ah, oo leh 41% homology ilaa hormoonka parathyroid (PTH) (1-34) iyo 76% homology ilaa PTHrP (1-34). Nidaamkeeda ficilku wuxuu ku lug leeyahay ku-xidhka PTH1R, soo-dhoweeyaha borotiinka-G ee lagu muujiyay osteoblasts iyo osteocytes. Iyada oo si gaar ah loogu xidhayo xaaladda qaabaysan ee RG ee PTH1R, abaloparatide waxay soo saartaa jawaab-celin ku-meel-gaar ah oo AMP ah oo wareegga wareegga ah, taasoo u horseedaysa dariiqa calaamadaha anabolic.
Dumarka postmenopausal ee qaba osteoporosis ee khatarta sare leh ee jabka, abaloparatide waa doorasho daaweyn oo waxtar leh. Waxay ka caawisaa kordhinta cufnaanta lafaha waxayna yaraynaysaa halista jabka. Intaa waxaa dheer, abaloparatide waxaa loo isticmaali karaa in lagu kordhiyo cufnaanta lafaha ee ragga qaba osteoporosis aasaasiga ah ama hypogonadal kuwaas oo halis sare ugu jira jabka ama ku guuldareystay ama aan u dulqaadan karin daaweynta kale ee la heli karo.
Intaa waxaa dheer, abaloparatide waxay siisaa faa'iidooyin ragga iyo dumarka labadaba qaba lafo-jileecu ee la xidhiidha daaweynta glucocorticoid ee joogtada ah. Shakhsiyaadkani waxay halis sare ugu jiraan jabka sababtoo ah isticmaalka muddada dheer ee glucocorticoids. Abaloparatide waxay kaa caawin kartaa hagaajinta xoogga lafaha waxayna yareyn kartaa khatarta jabka ee dadkan gaarka ah.
Abaloparatide, analoogga synthetic ee PTHrP, waa daaweyn qiimo leh oo loogu talagalay lafo-beelka. Astaamaha anabolic waxay kor u qaadaan koritaanka lafaha waxayna kordhiyaan cufnaanta lafaha, yaraynta khatarta jabka. Waxaa lagu tilmaamaa haweenka postmenopausal iyo ragga khatarta sare leh ee jabka, iyo sidoo kale shakhsiyaadka ku guuldareystay ama aan u dulqaadan karin daaweynta kale ee lafo-jileecu. Adigoo si xushmad leh u dhaqaajinaya PTH1R, abaloparatide waxay kicisaa dariiqa calaamadaha anabolic ee kor u qaadaya caafimaadka lafaha. Isticmaalkeeda osteoporosis ee la xidhiidha daaweynta glucocorticoid ee joogtada ah waxay siisaa ikhtiyaar daweyn oo muhiim ah shakhsiyaadka khatarta sare leh ee jabka. Abaloparatide waxay door muhiim ah ka ciyaartaa wax ka qabashada baahiyaha bukaanada qaba lafo-jileeca iyo hagaajinta caafimaadka lafaha iyo tayada nolosha.
