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Rosuvastatin wakiilka antilipemic Rosuvastatin wuxuu daaweeyaa dyslipidemia
Rosuvastatin wakiilka antilipemic Rosuvastatin wuxuu daaweeyaa dyslipidemia
Rosuvastatin wakiilka antilipemic Rosuvastatin wuxuu daaweeyaa dyslipidemia
Rosuvastatin wakiilka antilipemic Rosuvastatin wuxuu daaweeyaa dyslipidemia

Rosuvastatin wakiilka antilipemic Rosuvastatin wuxuu daaweeyaa dyslipidemia

Qiimaha tixraaca: USD 5-10/g

  • Magaca Alaabta Rosuvastatin
  • CAS Maya. 287714-41-4
  • MF C22H28FN3O6S
  • MW 481.54
  • EINECS 689-191-5
  • Cufnaanta 1.368±0.06 g/cm3 (La saadaaliyay)
  • barta dhalaalaysa 161.9 °C
Nala soo xiriir
faahfaahinta alaabta

Sharaxaad faahfaahsan

Rosuvastatin waxaa caadi ahaan loo qoraa daawooyinka loo isticmaalo daawaynta hypercholesterolemia iyo xaaladaha la xiriira. Daawadan, oo loo yaqaano statins, ayaa loo isticmaalaa marka lagu daro jimicsiga, xakamaynta cuntada, iyo miisaan lumis si loo hagaajiyo heerarka kolestaroolka iyo ka hortagga cudurada wadnaha. Qormadani waxay sahamin doontaa hababka ficilka iyo isticmaalka kiliinikada ee rosuvastatin, oo ay weheliso saamaynta ay ku leedahay cilladaha dufanka leh iyo guud ahaan caafimaadka wadnaha iyo xididdada dhiigga.

Rosuvastatin, oo lagu sifeeyay sida wakiilka antilipemic iyo xubin ka tirsan fasalka statin ee daawooyinka, ayaa ugu horreyn loo isticmaalaa in lagu daweeyo dyslipidemia, oo ay ku jiraan kolestaroolka sare. Waxay u shaqeysaa iyadoo xannibaysa enzyme-ka ku lug leh soosaarka kolestaroolka ee jirka, taasoo horseedaysa hoos u dhaca wadarta guud ee kolestaroolka iyo triglycerides, iyadoo isla mar ahaantaana la kordhinayo heerarka lipoprotein-cufnaanta sare (HDL) kolestaroolka, oo badanaa loo yaqaan 'kolestarool wanaagsan'. Rosuvastatin waxay waxtar u leedahay marka lagu daro cunto caafimaad leh iyo barnaamij jimicsi. Intaa waxaa dheer, waxaa loo isticmaalaa in lagu daweeyo shakhsiyaadka qaba cilladaha kolestaroolka ee la iska dhaxlo. Isticmaalka kiliinikada ee rosuvastatin waxaa ka mid ah daaweynta hypercholesterolemia aasaasiga ah, hypercholesterolemia qoyska, iyo cilladaha dufanka ee ay sababaan arrimo kale.


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Rosuvastatin waxay joojisaa enzyme hydroxymethylglutaryl-CoA reductase ee beerka, taas oo yaraynaysa isku dhafka kolestaroolka waxayna hoos u dhigtaa kolestaroolka serum iyo heerarka triglyceride. Intaa waxaa dheer, Rosuvastatin waxay kordhisaa qaadashada beerka iyo burburka kolestaroolka lipoprotein-ka cufan ee hooseeya (LDL-C), iyadoo sidoo kale kor u qaadeysa heerarka kolestaroolka cufnaanta sare ee lipoprotein (HDL-C). Marka lagu daro saameynteeda hoos u dhigista dufanka, Rosuvastatin waxaa lagu muujiyay inuu leeyahay anti-atherosclerotic, anti-bararka, antioxidant, xasilinta huurada, iyo hagaajinta sifooyinka shaqada endothelial.

Rosuvastatin waxa lagu soo saaraa halsano ee Aspergillus terreus ama kiimikaad. Marka la nuugo, si weyn ayaa loo dheefshiido beerka waxaana loo beddelaa dheef-shiid kiimikaad kala duwan, oo ay ku jiraan dheef-shiid kiimikaad firfircoon oo xannibaya HMG-CoA reductase. Daawada iyo dheef-shiid kiimikaadkeeda ayaa ugu horreyntii laga soo saaraa saxarada, iyadoo qadar yar laga soo saaro kaadida.


Iyada oo si tartan ah loo joojiyo HMG-CoA reductase, enzyme-ka xaddidaya heerka kolestaroolka, lovastatin wuxuu yareeyaa soosaarka kolestaroolka endogenous wuxuuna kordhiyaa muujinta soo-dhoweynta LDL ee unugyada beerka. Tani waxay keenaysaa korodhka heerka nadiifinta kolestaroolka LDL. Lovastatin waxay sidoo kale caawisaa hoos u dhigista heerarka serum triglyceride waxayna kordhisaa heerarka HDL kolestaroolka, ka qayb qaadashada ka hortagga iyo daaweynta atherosclerosis iyo cudurada wadnaha.

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Rosuvastatin waa dawo qiimo leh oo loogu talagalay daaweynta hypercholesterolemia iyo xaaladaha la xiriira. Rosuvastatin waxay ugu horreyn u shaqeysaa iyadoo xannibaysa soo saarista kolestaroolka waxayna hagaajinaysaa heerarka kolestaroolka iyada oo ay weheliso wax ka beddelka qaab nololeedka. Dhanka kale, waxay joojisaa isku-dhafka kolestaroolka waxayna kordhisaa qaadashada beerka iyo burburka kolestaroolka LDL, taasoo keentay hoos u dhaca heerarka kolestaroolka iyo triglyceride. Waxay muujisay waxtarka hagaajinta cilladaha dufanka iyo guud ahaan caafimaadka wadnaha iyo xididdada dhiigga. Waa muhiim inaad nala tashato hagaha xirfadlaha daryeelka caafimaadka si loo go'aamiyo isticmaalka ku habboon iyo qiyaasta daawooyinkan iyadoo lagu salaynayo baahiyaha shakhsi ahaaneed iyo taariikhda caafimaadka.

Tilmaamid

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