Vincristine Sulfate Budada Vincristine daahirsanaanta Vincristine CAS 57-22-7
Sharaxaad faahfaahsan
Vincristine waa budo crystalline ah oo cad ilaa cad. Waa ficil ahaan aan milmi karin biyaha, laakiin waxay ku milmaan qaar ka mid ah dareerayaasha organic. Xarunta saafiga ah waa mid aan ur lahayn waxaana sida caadiga ah lagu kaydiyaa meel qalalan, meel mugdi ah oo hoos yimaada xaaladaha heerkulka la xakameeyey si loo ilaaliyo xasilloonida. Waa alkaloid dabiici ah oo ka soo jeeda Madagascar periwinkle plant(Catharanthus roseus) , qaabdhismeedka kiimikaad wuxuu u eg yahay kii vinblastine, vinca alkaloids kale. .
Vincristine waa inhibitor microtubule ah oo carqaladeeya samaynta microtubules, kuwaas oo ah qaybaha lagama maarmaanka ah ee cytoskeleton unugga. Iyadoo lagu xirayo tubulin, waxay ka hortagtaa isku dhafka microtubules, taasoo horseedaysa xiritaanka mitotic iyo dhimashada unugyada si firfircoon u qaybiya unugyada. vincristine gaar ahaan wax ku ool ah oo ka dhan ah si degdeg ah u qaybinaya unugyada kansarka. Codsiyada kiliinikada ee vincristine waxaa ka mid ah daaweynta malignancies kala duwan sida acute lymphoblastic leukemia(ALL), Hodgkin's iyo non-Hodgkin's lymphomas, cudurada carruurta iyo dadka waaweyn ee burooyinka adag, neuroblastoma, iyo rhabdomyosarcoma inta badan waa la isticmaalaa Vincristine. marka lagu daro wakiilada kale ee kiimiko-daawaynta oo qayb ka ah hababka daawaynta dawooyinka badan, oo si wada jir ah loo yaqaano isku-darka kiimoterabiga.
Marka lagu daro isticmaalka aasaasiga ah ee daaweynta kansarka, vincristine ayaa sidoo kale muujisay waxtarka maareynta xaaladaha qaarkood ee aan ahayn oncological. Waxaa loo isticmaalaa daaweynta idiopathic thrombocytopenic purpura (ITP), cillad autoimmune ah oo lagu garto tiro yar oo platelet ah. , vincristine waxa uu muujiyay kartida maaraynta xaaladaha neerfayaasha kala duwan, oo ay ku jiraan bararka bararka demyelinating polyneuropathy (CIDP) iyo cudurrada nafsiga ah ee carruurta ee xanuunka dhimirka ee la xidhiidha caabuqyada streptococcal (PANDAS).
Intaa waxaa dheer, guryaha vincristine ee anti-angiogenic ayaa horseeday sahaminta isticmaalka suurtagalka ah ee daaweynta cudurrada faafa ee kala duwan, oo ay ku jiraan retinopathy sonkorowga iyo macular degeneration da'da. Marka la soo koobo, vincristine, oo ka soo jeeda dhirta periwinkle ee Madagascar, waa wakiil qiimo leh oo ka hortagga kansarka kaas oo carqaladeeya samaynta microtubule waxayna keentaa dhimashada unugyada qaybinta unugyada. codsiyada kiliinikada ballaaran ee kala duwan waxaa ka mid ah daaweynta leukemia, lymphoma, burooyinka adag, iyo xaaladaha aan kansarka ahayn qaarkood. Iyadoo isticmaalkeeda aasaasiga ah uu ku jiro daaweynta kansarka, cilmi-baaris joogto ah ayaa sii wadda inay sahamiso awooddeeda xaalado caafimaad oo kala duwan.
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